---
res:
  bibo_abstract:
  - Collective cell migration is coordinated by the front-to-rear intercellular propagation
    of EGFR-Ras-ERK pathway activation. However, the molecular mechanisms integrating
    front-to-rear information into this intercellular signaling cascade, particularly
    the determinants of cellular front-side specification, remain elusive. We visualized
    the activity of EGFR, Ras, Rac1 and Rab5A (hereafter Rab5) by using FRET biosensors
    and chemogenetic tools. Whereas EGFR activation was uniformly observed within
    cells, Ras activation was biased to the front side within cells. The polarized
    Ras activation depended on Merlin and Rac1, which also showed front-biased activation.
    Furthermore, Rab5, a crucial regulator of cell migration, demonstrated similar
    front-biased activation and was found to function downstream of Ras while being
    necessary for Rac1 activation. Thus, the positive feedback loop consisting of
    Ras, Rab5 and Rac1 is activated primarily at the front of collectively migrating
    cells. These findings offer new spatio-temporal insight into processing front–rear
    information during collective cell migration.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Yuya
      foaf_name: Jikko, Yuya
      foaf_surname: Jikko
  - foaf_Person:
      foaf_givenName: Eriko
      foaf_name: Deguchi, Eriko
      foaf_surname: Deguchi
  - foaf_Person:
      foaf_givenName: Kimiya
      foaf_name: Matsuda, Kimiya
      foaf_surname: Matsuda
  - foaf_Person:
      foaf_givenName: Naoya
      foaf_name: Hino, Naoya
      foaf_surname: Hino
      foaf_workInfoHomepage: http://www.librecat.org/personId=5299a9ce-7679-11eb-a7bc-d1e62b936307
  - foaf_Person:
      foaf_givenName: Shinya
      foaf_name: Tsukiji, Shinya
      foaf_surname: Tsukiji
  - foaf_Person:
      foaf_givenName: Michiyuki
      foaf_name: Matsuda, Michiyuki
      foaf_surname: Matsuda
  - foaf_Person:
      foaf_givenName: Kenta
      foaf_name: Terai, Kenta
      foaf_surname: Terai
  bibo_doi: 10.1242/jcs.263779
  bibo_issue: '15'
  bibo_volume: 138
  dct_date: 2025^xs_gYear
  dct_identifier:
  - UT:001567723900009
  dct_isPartOf:
  - http://id.crossref.org/issn/ 0021-9533
  - http://id.crossref.org/issn/1477-9137
  dct_language: eng
  dct_publisher: The Company of Biologists@
  dct_title: Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective
    cell migration@
  fabio_hasPubmedId: '40667649'
...