---
res:
  bibo_abstract:
  - The mammalian heart has long been considered a postmitotic organ, implying that
    the total number of cardiomyocytes is set at birth. Analysis of cell division
    in the mammalian heart is complicated by cardiomyocyte binucleation shortly after
    birth, which makes it challenging to interpret traditional assays of cell turnover
    [Laflamme MA, Murray CE (2011) Nature 473(7347):326–335; Bergmann O, et al. (2009)
    Science 324(5923):98–102]. An elegant multi-isotope imaging-mass spectrometry
    technique recently calculated the low, discrete rate of cardiomyocyte generation
    in mice [Senyo SE, et al. (2013) Nature 493(7432):433–436], yet our cellular-level
    understanding of postnatal cardiomyogenesis remains limited. Herein, we provide
    a new line of evidence for the differentiated α-myosin heavy chain-expressing
    cardiomyocyte as the cell of origin of postnatal cardiomyogenesis using the “mosaic
    analysis with double markers” mouse model. We show limited, life-long, symmetric
    division of cardiomyocytes as a rare event that is evident in utero but significantly
    diminishes after the first month of life in mice; daughter cardiomyocytes divide
    very seldom, which this study is the first to demonstrate, to our knowledge. Furthermore,
    ligation of the left anterior descending coronary artery, which causes a myocardial
    infarction in the mosaic analysis with double-marker mice, did not increase the
    rate of cardiomyocyte division above the basal level for up to 4 wk after the
    injury. The clonal analysis described here provides direct evidence of postnatal
    mammalian cardiomyogenesis.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Shah
      foaf_name: Ali, Shah
      foaf_surname: Ali
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Hippenmeyer, Simon
      foaf_surname: Hippenmeyer
      foaf_workInfoHomepage: http://www.librecat.org/personId=37B36620-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-2279-1061
  - foaf_Person:
      foaf_givenName: Lily
      foaf_name: Saadat, Lily
      foaf_surname: Saadat
  - foaf_Person:
      foaf_givenName: Liqun
      foaf_name: Luo, Liqun
      foaf_surname: Luo
  - foaf_Person:
      foaf_givenName: Irving
      foaf_name: Weissman, Irving
      foaf_surname: Weissman
  - foaf_Person:
      foaf_givenName: Reza
      foaf_name: Ardehali, Reza
      foaf_surname: Ardehali
  bibo_doi: 10.1073/pnas.1408233111
  bibo_issue: '24'
  bibo_volume: 111
  dct_date: 2014^xs_gYear
  dct_identifier:
  - UT:000337300100041
  dct_language: eng
  dct_publisher: National Academy of Sciences@
  dct_title: Existing cardiomyocytes generate cardiomyocytes at a low rate after birth
    in mice@
...