@article{20220,
  abstract     = {Stress granules (SG) are biomolecular condensates that represent an adaptive response of cells to various stresses, including heat. However, the cell type–specific function and relevance of SG formation, especially during reproductive development, are largely not understood. Here, we show that the meiotic A-type cyclin TARDY ASYNCHRONOUS MEIOSIS (TAM) is recruited to SGs in male meiocytes of Arabidopsis after exposure to heat. We find that the amino terminus of TAM is necessary and sufficient for the localization of proteins to meiotic SGs. Swapping the amino terminus of TAM with the one of its sister protein CYCA1;1 resulted in a separation-of-function allele of TAM, which prevents the partitioning of TAM to SGs while restoring a wild-type phenotype in a tam mutant background under nonheat stress conditions. Notably, plants expressing this TAM version prematurely terminate meiosis under heat resulting in unreduced gametes. Thus, the formation of TAM-containing SGs is necessary for genome stability under heat stress.},
  author       = {De Jaeger-Braet, Joke G and Hartmann, Merle and Böttger, Lev and Yang, Chao and Hamada, Takahiro and Hoth, Stefan and Feng, Xiaoqi and Weingartner, Magdalena and Schnittger, Arp},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {32},
  pages        = {eadr5694},
  publisher    = {AAAS},
  title        = {{The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat}},
  doi          = {10.1126/sciadv.adr5694},
  volume       = {11},
  year         = {2025},
}