[{"doi":"10.1126/sciadv.adr5694","type":"journal_article","citation":{"ieee":"J. G. De Jaeger-Braet <i>et al.</i>, “The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat,” <i>Science Advances</i>, vol. 11, no. 32. AAAS, p. eadr5694, 2025.","ama":"De Jaeger-Braet JG, Hartmann M, Böttger L, et al. The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat. <i>Science Advances</i>. 2025;11(32):eadr5694. doi:<a href=\"https://doi.org/10.1126/sciadv.adr5694\">10.1126/sciadv.adr5694</a>","mla":"De Jaeger-Braet, Joke G., et al. “The Recruitment of the A-Type Cyclin TAM to Stress Granules Is Crucial for Meiotic Fidelity under Heat.” <i>Science Advances</i>, vol. 11, no. 32, AAAS, 2025, p. eadr5694, doi:<a href=\"https://doi.org/10.1126/sciadv.adr5694\">10.1126/sciadv.adr5694</a>.","apa":"De Jaeger-Braet, J. G., Hartmann, M., Böttger, L., Yang, C., Hamada, T., Hoth, S., … Schnittger, A. (2025). The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat. <i>Science Advances</i>. AAAS. <a href=\"https://doi.org/10.1126/sciadv.adr5694\">https://doi.org/10.1126/sciadv.adr5694</a>","ista":"De Jaeger-Braet JG, Hartmann M, Böttger L, Yang C, Hamada T, Hoth S, Feng X, Weingartner M, Schnittger A. 2025. The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat. Science Advances. 11(32), eadr5694.","chicago":"De Jaeger-Braet, Joke G, Merle Hartmann, Lev Böttger, Chao Yang, Takahiro Hamada, Stefan Hoth, Xiaoqi Feng, Magdalena Weingartner, and Arp Schnittger. “The Recruitment of the A-Type Cyclin TAM to Stress Granules Is Crucial for Meiotic Fidelity under Heat.” <i>Science Advances</i>. AAAS, 2025. <a href=\"https://doi.org/10.1126/sciadv.adr5694\">https://doi.org/10.1126/sciadv.adr5694</a>.","short":"J.G. De Jaeger-Braet, M. Hartmann, L. Böttger, C. Yang, T. Hamada, S. Hoth, X. Feng, M. Weingartner, A. Schnittger, Science Advances 11 (2025) eadr5694."},"quality_controlled":"1","external_id":{"isi":["001549102600016"]},"department":[{"_id":"XiFe"}],"file_date_updated":"2025-09-02T07:05:37Z","page":"eadr5694","publication":"Science Advances","intvolume":"        11","month":"08","ec_funded":1,"issue":"32","language":[{"iso":"eng"}],"scopus_import":"1","OA_type":"gold","acknowledgement":"We thank L. Strader (Duke University, Durham) and A. Holehouse (Washington University, Saint Louis) for discussion and input in LLPS. We thank T. Nakagawa (Shimane University, Matsue) for providing the pGWB604 Gateway vector containing bar gene identified by Meiji Seika Kaisha Ltd. We thank M. Heese (Hamburg University) for the critical reading and comments on this manuscript. We further thank J. Mehrmann (Hamburg University) for technical assistance. We thank the ISTA imaging facility for assistance for microscopy.\r\nThis project has received funding from JST-PRESTO (JPMJPR18H7), JST-CREST (JPMJCR18H4), European Union’s Horizon 2020 under MSCA grant 101034413, and a federal grant from the state of Hamburg (LFF-BiCon).","article_processing_charge":"Yes","OA_place":"publisher","date_updated":"2025-09-30T14:24:10Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","title":"The recruitment of the A-type cyclin TAM to stress granules is crucial for meiotic fidelity under heat","publisher":"AAAS","abstract":[{"lang":"eng","text":"Stress granules (SG) are biomolecular condensates that represent an adaptive response of cells to various stresses, including heat. However, the cell type–specific function and relevance of SG formation, especially during reproductive development, are largely not understood. Here, we show that the meiotic A-type cyclin TARDY ASYNCHRONOUS MEIOSIS (TAM) is recruited to SGs in male meiocytes of Arabidopsis after exposure to heat. We find that the amino terminus of TAM is necessary and sufficient for the localization of proteins to meiotic SGs. Swapping the amino terminus of TAM with the one of its sister protein CYCA1;1 resulted in a separation-of-function allele of TAM, which prevents the partitioning of TAM to SGs while restoring a wild-type phenotype in a tam mutant background under nonheat stress conditions. Notably, plants expressing this TAM version prematurely terminate meiosis under heat resulting in unreduced gametes. Thus, the formation of TAM-containing SGs is necessary for genome stability under heat stress."}],"publication_status":"published","project":[{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413","call_identifier":"H2020"}],"volume":11,"ddc":["580"],"author":[{"id":"26bd38d3-c59a-11ee-a1af-d7a988cafcc5","first_name":"Joke G","last_name":"De Jaeger-Braet","full_name":"De Jaeger-Braet, Joke G"},{"last_name":"Hartmann","full_name":"Hartmann, Merle","first_name":"Merle"},{"full_name":"Böttger, Lev","last_name":"Böttger","first_name":"Lev"},{"full_name":"Yang, Chao","last_name":"Yang","first_name":"Chao","id":"082e3e6e-8069-11ed-8390-c8cce7b1aaca"},{"full_name":"Hamada, Takahiro","last_name":"Hamada","first_name":"Takahiro"},{"first_name":"Stefan","last_name":"Hoth","full_name":"Hoth, Stefan"},{"last_name":"Feng","orcid":"0000-0002-4008-1234","full_name":"Feng, Xiaoqi","first_name":"Xiaoqi","id":"e0164712-22ee-11ed-b12a-d80fcdf35958"},{"first_name":"Magdalena","full_name":"Weingartner, Magdalena","last_name":"Weingartner"},{"first_name":"Arp","full_name":"Schnittger, Arp","last_name":"Schnittger"}],"date_published":"2025-08-08T00:00:00Z","file":[{"file_name":"2025_ScienceAdvance_DeJaegerBraet.pdf","relation":"main_file","date_created":"2025-09-02T07:05:37Z","date_updated":"2025-09-02T07:05:37Z","checksum":"0f1ae246acc9b075f01bf4afe382c8ba","content_type":"application/pdf","file_size":10876817,"success":1,"creator":"dernst","file_id":"20270","access_level":"open_access"}],"tmp":{"short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"day":"08","year":"2025","article_type":"original","oa":1,"date_created":"2025-08-24T22:01:30Z","publication_identifier":{"eissn":["2375-2548"]},"acknowledged_ssus":[{"_id":"Bio"}],"has_accepted_license":"1","status":"public","_id":"20220","oa_version":"Published Version","DOAJ_listed":"1","isi":1}]