---
OA_place: repository
OA_type: green
_id: '203'
abstract:
- lang: eng
  text: Asymmetric auxin distribution is instrumental for the differential growth
    that causes organ bending on tropic stimuli and curvatures during plant development.
    Local differences in auxin concentrations are achieved mainly by polarized cellular
    distribution of PIN auxin transporters, but whether other mechanisms involving
    auxin homeostasis are also relevant for the formation of auxin gradients is not
    clear. Here we show that auxin methylation is required for asymmetric auxin distribution
    across the hypocotyl, particularly during its response to gravity. We found that
    loss-of-function mutants in Arabidopsis IAA CARBOXYL METHYLTRANSFERASE1 (IAMT1)
    prematurely unfold the apical hook, and that their hypocotyls are impaired in
    gravitropic reorientation. This defect is linked to an auxin-dependent increase
    in PIN gene expression, leading to an increased polar auxin transport and lack
    of asymmetric distribution of PIN3 in the iamt1 mutant. Gravitropic reorientation
    in the iamt1 mutant could be restored with either endodermis-specific expression
    of IAMT1 or partial inhibition of polar auxin transport, which also results in
    normal PIN gene expression levels. We propose that IAA methylation is necessary
    in gravity-sensing cells to restrict polar auxin transport within the range of
    auxin levels that allow for differential responses.
article_processing_charge: No
article_type: original
author:
- first_name: Mohamad
  full_name: Abbas, Mohamad
  id: 47E8FC1C-F248-11E8-B48F-1D18A9856A87
  last_name: Abbas
- first_name: García J
  full_name: Hernández, García J
  last_name: Hernández
- first_name: Stephan
  full_name: Pollmann, Stephan
  last_name: Pollmann
- first_name: Sophia L
  full_name: Samodelov, Sophia L
  last_name: Samodelov
- first_name: Martina
  full_name: Kolb, Martina
  last_name: Kolb
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Ulrich Z
  full_name: Hammes, Ulrich Z
  last_name: Hammes
- first_name: Matias D
  full_name: Zurbriggen, Matias D
  last_name: Zurbriggen
- first_name: Miguel
  full_name: Blázquez, Miguel
  last_name: Blázquez
- first_name: David
  full_name: Alabadí, David
  last_name: Alabadí
citation:
  ama: Abbas M, Hernández GJ, Pollmann S, et al. Auxin methylation is required for
    differential growth in Arabidopsis. <i>PNAS</i>. 2018;115(26):6864-6869. doi:<a
    href="https://doi.org/10.1073/pnas.1806565115">10.1073/pnas.1806565115</a>
  apa: Abbas, M., Hernández, G. J., Pollmann, S., Samodelov, S. L., Kolb, M., Friml,
    J., … Alabadí, D. (2018). Auxin methylation is required for differential growth
    in Arabidopsis. <i>PNAS</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1806565115">https://doi.org/10.1073/pnas.1806565115</a>
  chicago: Abbas, Mohamad, García J Hernández, Stephan Pollmann, Sophia L Samodelov,
    Martina Kolb, Jiří Friml, Ulrich Z Hammes, Matias D Zurbriggen, Miguel Blázquez,
    and David Alabadí. “Auxin Methylation Is Required for Differential Growth in Arabidopsis.”
    <i>PNAS</i>. National Academy of Sciences, 2018. <a href="https://doi.org/10.1073/pnas.1806565115">https://doi.org/10.1073/pnas.1806565115</a>.
  ieee: M. Abbas <i>et al.</i>, “Auxin methylation is required for differential growth
    in Arabidopsis,” <i>PNAS</i>, vol. 115, no. 26. National Academy of Sciences,
    pp. 6864–6869, 2018.
  ista: Abbas M, Hernández GJ, Pollmann S, Samodelov SL, Kolb M, Friml J, Hammes UZ,
    Zurbriggen MD, Blázquez M, Alabadí D. 2018. Auxin methylation is required for
    differential growth in Arabidopsis. PNAS. 115(26), 6864–6869.
  mla: Abbas, Mohamad, et al. “Auxin Methylation Is Required for Differential Growth
    in Arabidopsis.” <i>PNAS</i>, vol. 115, no. 26, National Academy of Sciences,
    2018, pp. 6864–69, doi:<a href="https://doi.org/10.1073/pnas.1806565115">10.1073/pnas.1806565115</a>.
  short: M. Abbas, G.J. Hernández, S. Pollmann, S.L. Samodelov, M. Kolb, J. Friml,
    U.Z. Hammes, M.D. Zurbriggen, M. Blázquez, D. Alabadí, PNAS 115 (2018) 6864–6869.
date_created: 2018-12-11T11:45:11Z
date_published: 2018-06-26T00:00:00Z
date_updated: 2026-04-28T08:29:26Z
day: '26'
department:
- _id: JiFr
doi: 10.1073/pnas.1806565115
ec_funded: 1
external_id:
  isi:
  - '000436245000096'
fulldoi: https://doi.org/10.1073/pnas.1806565115
intvolume: '       115'
isi: 1
issue: '26'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://eprints.nottingham.ac.uk/52388/
month: '06'
oa: 1
oa_version: Submitted Version
page: 6864-6869
project:
- _id: 25716A02-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '282300'
  name: Polarity and subcellular dynamics in plants
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '7710'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Auxin methylation is required for differential growth in Arabidopsis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 115
year: '2018'
...