article published yes Laura Hofmann author b88d43f2-dc74-11ea-a0a7-e41b7912e031 Carl-Philipp J Heisenberg author 39427864-F248-11E8-B48F-1D18A9856A870000-0002-0912-4566 CaHe department Oogenesis – the formation and development of an oocyte – is fundamental to reproduction and embryonic development. Due to its accessibility to genetic manipulations and the ability to culture and experimentally manipulate oocytes ex vivo, zebrafish has emerged as a powerful vertebrate model system for studying oogenesis. In this review, we provide a comprehensive overview of zebrafish oogenesis, from early germ cell formation to oocyte maturation and fertilization. We discuss recent advances in uncovering the molecular and cellular mechanisms driving this complex process and highlight key knowledge gaps that remain to be addressed. https://research-explorer.ista.ac.at/download/20349/20914/2025_SemCellDevBiology_Hofmann.pdf application/pdfno https://creativecommons.org/licenses/by/4.0/ Elsevier2025 eng 1084-9521 1096-3634 40913907 00156726010000110.1016/j.semcdb.2025.103650 175 Hofmann, Laura, and Carl-Philipp J Heisenberg. “Decoding Zebrafish Oogenesis: From Primordial Germ Cell Development to Fertilization.” <i>Seminars in Cell and Developmental Biology</i>. Elsevier, 2025. <a href="https://doi.org/10.1016/j.semcdb.2025.103650">https://doi.org/10.1016/j.semcdb.2025.103650</a>. Hofmann L, Heisenberg C-PJ. Decoding zebrafish oogenesis: From primordial germ cell development to fertilization. <i>Seminars in Cell and Developmental Biology</i>. 2025;175. doi:<a href="https://doi.org/10.1016/j.semcdb.2025.103650">10.1016/j.semcdb.2025.103650</a> L. Hofmann and C.-P. J. Heisenberg, “Decoding zebrafish oogenesis: From primordial germ cell development to fertilization,” <i>Seminars in Cell and Developmental Biology</i>, vol. 175. Elsevier, 2025. L. Hofmann, C.-P.J. Heisenberg, Seminars in Cell and Developmental Biology 175 (2025). Hofmann, L., &#38; Heisenberg, C.-P. J. (2025). Decoding zebrafish oogenesis: From primordial germ cell development to fertilization. <i>Seminars in Cell and Developmental Biology</i>. Elsevier. <a href="https://doi.org/10.1016/j.semcdb.2025.103650">https://doi.org/10.1016/j.semcdb.2025.103650</a> Hofmann L, Heisenberg C-PJ. 2025. Decoding zebrafish oogenesis: From primordial germ cell development to fertilization. Seminars in Cell and Developmental Biology. 175, 103650. Hofmann, Laura, and Carl-Philipp J. Heisenberg. “Decoding Zebrafish Oogenesis: From Primordial Germ Cell Development to Fertilization.” <i>Seminars in Cell and Developmental Biology</i>, vol. 175, 103650, Elsevier, 2025, doi:<a href="https://doi.org/10.1016/j.semcdb.2025.103650">10.1016/j.semcdb.2025.103650</a>. 203492025-09-14T22:01:32Z2025-12-30T10:21:13Z