---
res:
  bibo_abstract:
  - ' In rapidly changing environments, selection history may impact the dynamics
    of adaptation. Mutations selected in one environment may result in pleiotropic
    fitness trade-offs in subsequent novel environments, slowing the rates of adaptation.
    Epistatic interactions between mutations selected in sequential stressful environments
    may slow or accelerate subsequent rates of adaptation, depending on the nature
    of that interaction. We explored the dynamics of adaptation during sequential
    exposure to herbicides with different modes of action in Chlamydomonas reinhardtii.
    Evolution of resistance to two of the herbicides was largely independent of selection
    history. For carbetamide, previous adaptation to other herbicide modes of action
    positively impacted the likelihood of adaptation to this herbicide. Furthermore,
    while adaptation to all individual herbicides was associated with pleiotropic
    fitness costs in stress-free environments, we observed that accumulation of resistance
    mechanisms was accompanied by a reduction in overall fitness costs. We suggest
    that antagonistic epistasis may be a driving mechanism that enables populations
    to more readily adapt in novel environments. These findings highlight the potential
    for sequences of xenobiotics to facilitate the rapid evolution of multiple-drug
    and -pesticide resistance, as well as the potential for epistatic interactions
    between adaptive mutations to facilitate evolutionary rescue in rapidly changing
    environments. @eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Mato
      foaf_name: Lagator, Mato
      foaf_surname: Lagator
      foaf_workInfoHomepage: http://www.librecat.org/personId=345D25EC-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Nick
      foaf_name: Colegrave, Nick
      foaf_surname: Colegrave
  - foaf_Person:
      foaf_givenName: Paul
      foaf_name: Neve, Paul
      foaf_surname: Neve
  bibo_doi: 10.1098/rspb.2014.1679
  bibo_issue: '1794'
  bibo_volume: 281
  dct_date: 2014^xs_gYear
  dct_identifier:
  - UT:000341922700009
  dct_language: eng
  dct_publisher: Royal Society@
  dct_title: Selection history and epistatic interactions impact dynamics of adaptation
    to novel environmental stresses@
...