---
_id: '2036'
abstract:
- lang: eng
  text: ' In rapidly changing environments, selection history may impact the dynamics
    of adaptation. Mutations selected in one environment may result in pleiotropic
    fitness trade-offs in subsequent novel environments, slowing the rates of adaptation.
    Epistatic interactions between mutations selected in sequential stressful environments
    may slow or accelerate subsequent rates of adaptation, depending on the nature
    of that interaction. We explored the dynamics of adaptation during sequential
    exposure to herbicides with different modes of action in Chlamydomonas reinhardtii.
    Evolution of resistance to two of the herbicides was largely independent of selection
    history. For carbetamide, previous adaptation to other herbicide modes of action
    positively impacted the likelihood of adaptation to this herbicide. Furthermore,
    while adaptation to all individual herbicides was associated with pleiotropic
    fitness costs in stress-free environments, we observed that accumulation of resistance
    mechanisms was accompanied by a reduction in overall fitness costs. We suggest
    that antagonistic epistasis may be a driving mechanism that enables populations
    to more readily adapt in novel environments. These findings highlight the potential
    for sequences of xenobiotics to facilitate the rapid evolution of multiple-drug
    and -pesticide resistance, as well as the potential for epistatic interactions
    between adaptive mutations to facilitate evolutionary rescue in rapidly changing
    environments. '
acknowledgement: The project was supported by Leverhulme Trust.
article_number: '20141679'
article_processing_charge: No
author:
- first_name: Mato
  full_name: Lagator, Mato
  id: 345D25EC-F248-11E8-B48F-1D18A9856A87
  last_name: Lagator
- first_name: Nick
  full_name: Colegrave, Nick
  last_name: Colegrave
- first_name: Paul
  full_name: Neve, Paul
  last_name: Neve
citation:
  ama: Lagator M, Colegrave N, Neve P. Selection history and epistatic interactions
    impact dynamics of adaptation to novel environmental stresses. <i>Proceedings
    of the Royal Society of London Series B Biological Sciences</i>. 2014;281(1794).
    doi:<a href="https://doi.org/10.1098/rspb.2014.1679">10.1098/rspb.2014.1679</a>
  apa: Lagator, M., Colegrave, N., &#38; Neve, P. (2014). Selection history and epistatic
    interactions impact dynamics of adaptation to novel environmental stresses. <i>Proceedings
    of the Royal Society of London Series B Biological Sciences</i>. Royal Society.
    <a href="https://doi.org/10.1098/rspb.2014.1679">https://doi.org/10.1098/rspb.2014.1679</a>
  chicago: Lagator, Mato, Nick Colegrave, and Paul Neve. “Selection History and Epistatic
    Interactions Impact Dynamics of Adaptation to Novel Environmental Stresses.” <i>Proceedings
    of the Royal Society of London Series B Biological Sciences</i>. Royal Society,
    2014. <a href="https://doi.org/10.1098/rspb.2014.1679">https://doi.org/10.1098/rspb.2014.1679</a>.
  ieee: M. Lagator, N. Colegrave, and P. Neve, “Selection history and epistatic interactions
    impact dynamics of adaptation to novel environmental stresses,” <i>Proceedings
    of the Royal Society of London Series B Biological Sciences</i>, vol. 281, no.
    1794. Royal Society, 2014.
  ista: Lagator M, Colegrave N, Neve P. 2014. Selection history and epistatic interactions
    impact dynamics of adaptation to novel environmental stresses. Proceedings of
    the Royal Society of London Series B Biological Sciences. 281(1794), 20141679.
  mla: Lagator, Mato, et al. “Selection History and Epistatic Interactions Impact
    Dynamics of Adaptation to Novel Environmental Stresses.” <i>Proceedings of the
    Royal Society of London Series B Biological Sciences</i>, vol. 281, no. 1794,
    20141679, Royal Society, 2014, doi:<a href="https://doi.org/10.1098/rspb.2014.1679">10.1098/rspb.2014.1679</a>.
  short: M. Lagator, N. Colegrave, P. Neve, Proceedings of the Royal Society of London
    Series B Biological Sciences 281 (2014).
date_created: 2018-12-11T11:55:21Z
date_published: 2014-09-17T00:00:00Z
date_updated: 2026-08-12T06:26:10Z
day: '17'
department:
- _id: CaGu
doi: 10.1098/rspb.2014.1679
external_id:
  isi:
  - '000341922700009'
intvolume: '       281'
isi: 1
issue: '1794'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211454/
month: '09'
oa: 1
oa_version: Submitted Version
publication: Proceedings of the Royal Society of London Series B Biological Sciences
publication_status: published
publisher: Royal Society
publist_id: '5019'
quality_controlled: '1'
related_material:
  record:
  - id: '9741'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Selection history and epistatic interactions impact dynamics of adaptation
  to novel environmental stresses
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 281
year: '2014'
...