---
_id: '2041'
abstract:
- lang: eng
  text: The hippocampus mediates several higher brain functions, such as learning,
    memory, and spatial coding. The input region of the hippocampus, the dentate gyrus,
    plays a critical role in these processes. Several lines of evidence suggest that
    the dentate gyrus acts as a preprocessor of incoming information, preparing it
    for subsequent processing in CA3. For example, the dentate gyrus converts input
    from the entorhinal cortex, where cells have multiple spatial fields, into the
    spatially more specific place cell activity characteristic of the CA3 region.
    Furthermore, the dentate gyrus is involved in pattern separation, transforming
    relatively similar input patterns into substantially different output patterns.
    Finally, the dentate gyrus produces a very sparse coding scheme in which only
    a very small fraction of neurons are active at any one time.
article_number: 2p
article_processing_charge: No
author:
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: John
  full_name: Lisman, John
  last_name: Lisman
citation:
  ama: Jonas PM, Lisman J. Structure, function and plasticity of hippocampal dentate
    gyrus microcircuits. <i>Frontiers in Neural Circuits</i>. 2014;8. doi:<a href="https://doi.org/10.3389/fncir.2014.00107">10.3389/fncir.2014.00107</a>
  apa: Jonas, P. M., &#38; Lisman, J. (2014). Structure, function and plasticity of
    hippocampal dentate gyrus microcircuits. <i>Frontiers in Neural Circuits</i>.
    Frontiers Research Foundation. <a href="https://doi.org/10.3389/fncir.2014.00107">https://doi.org/10.3389/fncir.2014.00107</a>
  chicago: Jonas, Peter M, and John Lisman. “Structure, Function and Plasticity of
    Hippocampal Dentate Gyrus Microcircuits.” <i>Frontiers in Neural Circuits</i>.
    Frontiers Research Foundation, 2014. <a href="https://doi.org/10.3389/fncir.2014.00107">https://doi.org/10.3389/fncir.2014.00107</a>.
  ieee: P. M. Jonas and J. Lisman, “Structure, function and plasticity of hippocampal
    dentate gyrus microcircuits,” <i>Frontiers in Neural Circuits</i>, vol. 8. Frontiers
    Research Foundation, 2014.
  ista: Jonas PM, Lisman J. 2014. Structure, function and plasticity of hippocampal
    dentate gyrus microcircuits. Frontiers in Neural Circuits. 8, 2p.
  mla: Jonas, Peter M., and John Lisman. “Structure, Function and Plasticity of Hippocampal
    Dentate Gyrus Microcircuits.” <i>Frontiers in Neural Circuits</i>, vol. 8, 2p,
    Frontiers Research Foundation, 2014, doi:<a href="https://doi.org/10.3389/fncir.2014.00107">10.3389/fncir.2014.00107</a>.
  short: P.M. Jonas, J. Lisman, Frontiers in Neural Circuits 8 (2014).
corr_author: '1'
date_created: 2018-12-11T11:55:22Z
date_published: 2014-09-10T00:00:00Z
date_updated: 2025-09-29T11:52:44Z
day: '10'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.3389/fncir.2014.00107
external_id:
  isi:
  - '000341953300001'
file:
- access_level: open_access
  checksum: 3ca57b164045523f876407e9f13a9fb8
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:17:38Z
  date_updated: 2020-07-14T12:45:26Z
  file_id: '5294'
  file_name: IST-2016-424-v1+1_fncir-08-00107.pdf
  file_size: 201110
  relation: main_file
file_date_updated: 2020-07-14T12:45:26Z
fulldoi: https://doi.org/10.3389/fncir.2014.00107
has_accepted_license: '1'
intvolume: '         8'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '09'
oa: 1
oa_version: Published Version
publication: Frontiers in Neural Circuits
publication_status: published
publisher: Frontiers Research Foundation
publist_id: '5010'
pubrep_id: '424'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structure, function and plasticity of hippocampal dentate gyrus microcircuits
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 8
year: '2014'
...