---
res:
  bibo_abstract:
  - Homeostasis relies on a precise balance of fate choices between renewal and differentiation.
    Although progress has been done to characterize the dynamics of single-cell fate
    choices, their underlying mechanistic basis often remains unclear. Concentrating
    on skin epidermis as a paradigm for multilayered tissues with complex fate choices,
    we develop a 3D vertex-based model with proliferation in the basal layer, showing
    that mechanical competition for space naturally gives rise to homeostasis and
    neutral drift dynamics that are seen experimentally. We then explore the effect
    of introducing mechanical heterogeneities between cellular subpopulations. We
    uncover that relatively small tension heterogeneities, reflected by distinct morphological
    changes in single-cell shapes, can be sufficient to heavily tilt cellular dynamics
    towards exponential growth. We thus derive a master relationship between cell
    shape and long-term clonal dynamics, which we validated during basal cell carcinoma
    initiation in mouse epidermis. Altogether, we propose a theoretical framework
    to link mechanical forces, quantitative cellular morphologies and cellular fate
    outcomes in complex tissues.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Preeti
      foaf_name: Sahu, Preeti
      foaf_surname: Sahu
      foaf_workInfoHomepage: http://www.librecat.org/personId=55BA52EE-A185-11EA-88FD-18AD3DDC885E
  - foaf_Person:
      foaf_givenName: Sara
      foaf_name: Monteiro-Ferreira, Sara
      foaf_surname: Monteiro-Ferreira
  - foaf_Person:
      foaf_givenName: Sara
      foaf_name: Canato, Sara
      foaf_surname: Canato
  - foaf_Person:
      foaf_givenName: Raquel Maia
      foaf_name: Soares, Raquel Maia
      foaf_surname: Soares
  - foaf_Person:
      foaf_givenName: Adriana
      foaf_name: Sánchez-Danés, Adriana
      foaf_surname: Sánchez-Danés
  - foaf_Person:
      foaf_givenName: Edouard B
      foaf_name: Hannezo, Edouard B
      foaf_surname: Hannezo
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A9DB764-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6005-1561
  bibo_doi: 10.1038/s41467-025-62882-9
  bibo_volume: 16
  dct_date: 2025^xs_gYear
  dct_identifier:
  - UT:001582555200011
  dct_isPartOf:
  - http://id.crossref.org/issn/2041-1723
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Mechanical control of cell fate decisions in the skin epidermis@
  fabio_hasPubmedId: '41006218'
...