---
res:
  bibo_abstract:
  - Haptotaxis is the process of directed cell migration along gradients of extracellular
    matrix density and is central to morphogenesis, immune responses and cancer invasion.
    It is commonly assumed that cells respond to these gradients by migrating directionally
    towards the regions of highest ligand density. In contrast with this view, here
    we show that cells exposed to micropatterned fibronectin gradients exhibit a wide
    range of complex trajectories, including directed haptotactic migration up the
    gradient but also linear oscillations and circles with extended periods of migration
    down the gradient. To explain this behaviour, we developed a biophysical model
    of haptotactic cell migration based on a coarse-grained molecular clutch model
    coupled to persistent stochastic polarity dynamics. Although initial haptotactic
    migration is explained by the differential friction at the front and back of the
    cell, the observed complex trajectories over longer timescales arise from the
    interplay between differential friction, persistence and physical confinement.
    Overall, our study reveals that confinement and persistence modulate the ability
    of cells to sense and respond to haptotactic cues and provides a framework for
    understanding how cells navigate complex environments.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Isabela Corina
      foaf_name: Fortunato, Isabela Corina
      foaf_surname: Fortunato
  - foaf_Person:
      foaf_givenName: David
      foaf_name: Brückner, David
      foaf_surname: Brückner
      foaf_workInfoHomepage: http://www.librecat.org/personId=e1e86031-6537-11eb-953a-f7ab92be508d
    orcid: 0000-0001-7205-2975
  - foaf_Person:
      foaf_givenName: Steffen
      foaf_name: Grosser, Steffen
      foaf_surname: Grosser
  - foaf_Person:
      foaf_givenName: Rohit
      foaf_name: Nautiyal, Rohit
      foaf_surname: Nautiyal
  - foaf_Person:
      foaf_givenName: Leone
      foaf_name: Rossetti, Leone
      foaf_surname: Rossetti
  - foaf_Person:
      foaf_givenName: Miquel
      foaf_name: Bosch-Padrós, Miquel
      foaf_surname: Bosch-Padrós
  - foaf_Person:
      foaf_givenName: Jonel
      foaf_name: Trebicka, Jonel
      foaf_surname: Trebicka
  - foaf_Person:
      foaf_givenName: Pere
      foaf_name: Roca-Cusachs, Pere
      foaf_surname: Roca-Cusachs
  - foaf_Person:
      foaf_givenName: Raimon
      foaf_name: Sunyer, Raimon
      foaf_surname: Sunyer
  - foaf_Person:
      foaf_givenName: Edouard B
      foaf_name: Hannezo, Edouard B
      foaf_surname: Hannezo
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A9DB764-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6005-1561
  - foaf_Person:
      foaf_givenName: Xavier
      foaf_name: Trepat, Xavier
      foaf_surname: Trepat
  bibo_doi: 10.1038/s41567-025-03015-3
  bibo_volume: 21
  dct_date: 2025^xs_gYear
  dct_identifier:
  - UT:001581659900001
  dct_isPartOf:
  - http://id.crossref.org/issn/1745-2473
  - http://id.crossref.org/issn/1745-2481
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Single-cell migration along and against confined haptotactic gradients@
...