{"status":"public","scopus_import":"1","type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"pmid":["41043435"]},"publication_status":"epub_ahead","department":[{"_id":"JiFr"}],"date_published":"2025-10-02T00:00:00Z","doi":"10.1016/j.devcel.2025.09.009","_id":"20636","publication":"Developmental Cell","article_processing_charge":"No","OA_type":"closed access","date_created":"2025-11-12T10:03:39Z","publisher":"Elsevier","language":[{"iso":"eng"}],"year":"2025","pmid":1,"day":"02","quality_controlled":"1","page":"S1534-5807(25)00569-6","acknowledgement":"We thank Lukáš Fiedler‬ for helping with the writing. This work was supported by the National Key Research and Development Program of China (2023YFA0913500) to T.X., R.H., Y.Y., Y.X., and M.W. and by the National Natural Science Foundation of China grants to T.X. (32130010), Z.Y. (3241101698), and R.H. (32070309 and 32470276) and startup funds from the Fujian Agriculture and Forestry University and the Shanghai Plant Stress Biology Center, Chinese Academy of Sciences to T.X.","article_type":"original","date_updated":"2025-11-24T13:43:08Z","oa_version":"None","citation":{"chicago":"Huang, R, J Wang, M Chang, W Tang, Y Yu, Y Zhang, Y Peng, et al. “TMK-PIN1 Drives a Short Self-Organizing Circuit for Auxin Export and Signaling in Arabidopsis.” <i>Developmental Cell</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.devcel.2025.09.009\">https://doi.org/10.1016/j.devcel.2025.09.009</a>.","short":"R. Huang, J. Wang, M. Chang, W. Tang, Y. Yu, Y. Zhang, Y. Peng, Y. Wang, Y. Guo, T. Lu, Y. Cao, Y. Zhou, Q. Zhang, Y. Huang, A. Wu, L. Ren, M.C. Gallei, J. Dong, H. Chen, J. He, M. Wen, J. Friml, L. Sun, Y. Xiong, Z. Yang, T. Xu, Developmental Cell (2025) S1534-5807(25)00569–6.","mla":"Huang, R., et al. “TMK-PIN1 Drives a Short Self-Organizing Circuit for Auxin Export and Signaling in Arabidopsis.” <i>Developmental Cell</i>, Elsevier, 2025, pp. S1534-5807(25)00569-6, doi:<a href=\"https://doi.org/10.1016/j.devcel.2025.09.009\">10.1016/j.devcel.2025.09.009</a>.","apa":"Huang, R., Wang, J., Chang, M., Tang, W., Yu, Y., Zhang, Y., … Xu, T. (2025). TMK-PIN1 drives a short self-organizing circuit for auxin export and signaling in Arabidopsis. <i>Developmental Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2025.09.009\">https://doi.org/10.1016/j.devcel.2025.09.009</a>","ista":"Huang R, Wang J, Chang M, Tang W, Yu Y, Zhang Y, Peng Y, Wang Y, Guo Y, Lu T, Cao Y, Zhou Y, Zhang Q, Huang Y, Wu A, Ren L, Gallei MC, Dong J, Chen H, He J, Wen M, Friml J, Sun L, Xiong Y, Yang Z, Xu T. 2025. TMK-PIN1 drives a short self-organizing circuit for auxin export and signaling in Arabidopsis. Developmental Cell., S1534-5807(25)00569–6.","ieee":"R. Huang <i>et al.</i>, “TMK-PIN1 drives a short self-organizing circuit for auxin export and signaling in Arabidopsis,” <i>Developmental Cell</i>. Elsevier, pp. S1534-5807(25)00569–6, 2025.","ama":"Huang R, Wang J, Chang M, et al. TMK-PIN1 drives a short self-organizing circuit for auxin export and signaling in Arabidopsis. <i>Developmental Cell</i>. 2025:S1534-5807(25)00569-6. doi:<a href=\"https://doi.org/10.1016/j.devcel.2025.09.009\">10.1016/j.devcel.2025.09.009</a>"},"publication_identifier":{"issn":["1534-5807"],"eissn":["1878-1551"]},"month":"10","title":"TMK-PIN1 drives a short self-organizing circuit for auxin export and signaling in Arabidopsis","abstract":[{"lang":"eng","text":"The versatile and pivotal roles of the phytohormone auxin in regulating plant growth and development are typically linked to its directional transport, relying on the polarized PIN-FORMED (PIN) auxin exporters at the plasma membrane (PM). For decades, auxin has been proposed to promote PIN polarization, generating self-regulatory feedback mediating much of plant development, but mechanistic insight into this regulation is lacking. Here, we uncover an auxin-induced protein complex at the PM, containing auxin co-receptors transmembrane kinases (TMKs) and PIN1 auxin exporter, as the core machinery that underlies this feedback regulation. Auxin promotes PIN1 phosphorylation by TMKs, modulating PIN1 polarization and transport activity. We also provide evidence that PIN1-exported extracellular auxin is crucial for TMK activation and cell elongation, thus forming the simplest two-element self-regulatory feedback circuit. Thus, these findings offer direct mechanistic insights into a potential self-organizing circuit for auxin signaling and transport to ensure proper plant development in Arabidopsis."}],"author":[{"first_name":"R","full_name":"Huang, R","last_name":"Huang"},{"last_name":"Wang","full_name":"Wang, J","first_name":"J"},{"first_name":"M","full_name":"Chang, M","last_name":"Chang"},{"first_name":"W","last_name":"Tang","full_name":"Tang, W"},{"last_name":"Yu","full_name":"Yu, Y","first_name":"Y"},{"first_name":"Y","last_name":"Zhang","full_name":"Zhang, Y"},{"first_name":"Y","full_name":"Peng, Y","last_name":"Peng"},{"first_name":"Y","last_name":"Wang","full_name":"Wang, Y"},{"full_name":"Guo, Y","last_name":"Guo","first_name":"Y"},{"first_name":"T","full_name":"Lu, T","last_name":"Lu"},{"last_name":"Cao","full_name":"Cao, Y","first_name":"Y"},{"full_name":"Zhou, Y","last_name":"Zhou","first_name":"Y"},{"first_name":"Q","full_name":"Zhang, Q","last_name":"Zhang"},{"first_name":"Y","last_name":"Huang","full_name":"Huang, Y"},{"last_name":"Wu","full_name":"Wu, A","first_name":"A"},{"first_name":"L","full_name":"Ren, L","last_name":"Ren"},{"first_name":"Michelle C","orcid":"0000-0003-1286-7368","last_name":"Gallei","full_name":"Gallei, Michelle C","id":"35A03822-F248-11E8-B48F-1D18A9856A87"},{"first_name":"J","full_name":"Dong, J","last_name":"Dong"},{"full_name":"Chen, H","last_name":"Chen","first_name":"H"},{"full_name":"He, J","last_name":"He","first_name":"J"},{"first_name":"M","full_name":"Wen, M","last_name":"Wen"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","full_name":"Friml, Jiří","orcid":"0000-0002-8302-7596","first_name":"Jiří"},{"first_name":"L","full_name":"Sun, L","last_name":"Sun"},{"first_name":"Y","full_name":"Xiong, Y","last_name":"Xiong"},{"full_name":"Yang, Z","last_name":"Yang","first_name":"Z"},{"first_name":"T","last_name":"Xu","full_name":"Xu, T"}]}