[{"publication":"Genetical Research","dc":{"title":["A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila"],"rights":["info:eu-repo/semantics/closedAccess"],"creator":["Beatriz Vicoso","Haddrill, Penelope R","Charlesworth, Brian"],"publisher":["Cambridge University Press"],"type":["info:eu-repo/semantics/article","doc-type:article","text","http://purl.org/coar/resource_type/c_6501"],"date":["2008"],"identifier":["https://research-explorer.ista.ac.at/record/2065"],"description":["Population genetics models show that, under certain conditions, the X chromosome is expected to be under more efficient selection than the autosomes. This could lead to 'faster-X evolution', if a large proportion of mutations are fixed by positive selection, as suggested by recent studies in Drosophila. We used a multispecies approach to test this: Muller's element D, an autosomal arm, is fused to the ancestral X chromosome in Drosophila pseudoobscura and its sister species, Drosophila affinis. We tested whether the same set of genes had higher rates of non-synonymous evolution when they were X-linked (in the D. pseudoobscura/D. affinis comparison) than when they were autosomal (in Drosophila melanogaster/Drosophila yakuba). Although not significant, our results suggest this may be the case, but only for genes under particularly strong positive selection/weak purifying selection. They also suggest that genes that have become X-linked have higher levels of codon bias and slower synonymous site evolution, consistent with more effective selection on codon usage at X-linked sites."],"source":["Vicoso B, Haddrill P, Charlesworth B. A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila. Genetical Research. 2008;90(5):421-431. doi:10.1017/S0016672308009804"],"relation":["info:eu-repo/semantics/altIdentifier/doi/10.1017/S0016672308009804"]},"day":"01","publication_status":"published","date_created":"2018-12-11T11:55:30Z","issue":"5","date_published":"2008-10-01T00:00:00Z","volume":90,"uri_base":"https://research-explorer.ista.ac.at","page":"421 - 431","acknowledgement":"B.V. was supported by the Portuguese Foundation for Science and Technology, P.R.H. is supported by the Natural Environmental Research Council (UK) and B.C. was supported by the Royal Society (UK)","abstract":[{"lang":"eng"}],"intvolume":" 90","month":"10","quality_controlled":0,"extern":1,"citation":{"mla":"Vicoso, Beatriz, et al. “A Multispecies Approach for Comparing Sequence Evolution of X-Linked and Autosomal Sites in Drosophila.” Genetical Research, vol. 90, no. 5, Cambridge University Press, 2008, pp. 421–31, doi:10.1017/S0016672308009804.","apa":"Vicoso, B., Haddrill, P., & Charlesworth, B. (2008). A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila. Genetical Research. Cambridge University Press. https://doi.org/10.1017/S0016672308009804","ieee":"B. Vicoso, P. Haddrill, and B. Charlesworth, “A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila,” Genetical Research, vol. 90, no. 5. Cambridge University Press, pp. 421–431, 2008.","short":"B. Vicoso, P. Haddrill, B. Charlesworth, Genetical Research 90 (2008) 421–431.","chicago":"Vicoso, Beatriz, Penelope Haddrill, and Brian Charlesworth. “A Multispecies Approach for Comparing Sequence Evolution of X-Linked and Autosomal Sites in Drosophila.” Genetical Research. Cambridge University Press, 2008. https://doi.org/10.1017/S0016672308009804.","ista":"Vicoso B, Haddrill P, Charlesworth B. 2008. A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila. Genetical Research. 90(5), 421–431."},"dini_type":"doc-type:article","date_updated":"2021-01-12T06:55:05Z","author":[{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","first_name":"Beatriz","orcid":"0000-0002-4579-8306","last_name":"Vicoso"},{"first_name":"Penelope","last_name":"Haddrill"},{"first_name":"Brian","last_name":"Charlesworth"}],"publist_id":"4972","_id":"2065","status":"public","type":"journal_article"}]