---
_id: '2065'
abstract:
- lang: eng
text: 'Population genetics models show that, under certain conditions, the X chromosome
is expected to be under more efficient selection than the autosomes. This could
lead to ''faster-X evolution'', if a large proportion of mutations are fixed by
positive selection, as suggested by recent studies in Drosophila. We used a multispecies
approach to test this: Muller''s element D, an autosomal arm, is fused to the
ancestral X chromosome in Drosophila pseudoobscura and its sister species, Drosophila
affinis. We tested whether the same set of genes had higher rates of non-synonymous
evolution when they were X-linked (in the D. pseudoobscura/D. affinis comparison)
than when they were autosomal (in Drosophila melanogaster/Drosophila yakuba).
Although not significant, our results suggest this may be the case, but only for
genes under particularly strong positive selection/weak purifying selection. They
also suggest that genes that have become X-linked have higher levels of codon
bias and slower synonymous site evolution, consistent with more effective selection
on codon usage at X-linked sites.'
acknowledgement: B.V. was supported by the Portuguese Foundation for Science and Technology,
P.R.H. is supported by the Natural Environmental Research Council (UK) and B.C.
was supported by the Royal Society (UK)
author:
- first_name: Beatriz
full_name: Beatriz Vicoso
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
- first_name: Penelope
full_name: Haddrill, Penelope R
last_name: Haddrill
- first_name: Brian
full_name: Charlesworth, Brian
last_name: Charlesworth
citation:
ama: Vicoso B, Haddrill P, Charlesworth B. A multispecies approach for comparing
sequence evolution of X-linked and autosomal sites in Drosophila. Genetical
Research. 2008;90(5):421-431. doi:10.1017/S0016672308009804
apa: Vicoso, B., Haddrill, P., & Charlesworth, B. (2008). A multispecies approach
for comparing sequence evolution of X-linked and autosomal sites in Drosophila.
Genetical Research. Cambridge University Press. https://doi.org/10.1017/S0016672308009804
chicago: Vicoso, Beatriz, Penelope Haddrill, and Brian Charlesworth. “A Multispecies
Approach for Comparing Sequence Evolution of X-Linked and Autosomal Sites in Drosophila.”
Genetical Research. Cambridge University Press, 2008. https://doi.org/10.1017/S0016672308009804.
ieee: B. Vicoso, P. Haddrill, and B. Charlesworth, “A multispecies approach for
comparing sequence evolution of X-linked and autosomal sites in Drosophila,” Genetical
Research, vol. 90, no. 5. Cambridge University Press, pp. 421–431, 2008.
ista: Vicoso B, Haddrill P, Charlesworth B. 2008. A multispecies approach for comparing
sequence evolution of X-linked and autosomal sites in Drosophila. Genetical Research.
90(5), 421–431.
mla: Vicoso, Beatriz, et al. “A Multispecies Approach for Comparing Sequence Evolution
of X-Linked and Autosomal Sites in Drosophila.” Genetical Research, vol.
90, no. 5, Cambridge University Press, 2008, pp. 421–31, doi:10.1017/S0016672308009804.
short: B. Vicoso, P. Haddrill, B. Charlesworth, Genetical Research 90 (2008) 421–431.
date_created: 2018-12-11T11:55:30Z
date_published: 2008-10-01T00:00:00Z
date_updated: 2021-01-12T06:55:05Z
day: '01'
doi: 10.1017/S0016672308009804
extern: 1
intvolume: ' 90'
issue: '5'
month: '10'
page: 421 - 431
publication: Genetical Research
publication_status: published
publisher: Cambridge University Press
publist_id: '4972'
quality_controlled: 0
status: public
title: A multispecies approach for comparing sequence evolution of X-linked and autosomal
sites in Drosophila
type: journal_article
volume: 90
year: '2008'
...