--- _id: '2065' abstract: - lang: eng text: 'Population genetics models show that, under certain conditions, the X chromosome is expected to be under more efficient selection than the autosomes. This could lead to ''faster-X evolution'', if a large proportion of mutations are fixed by positive selection, as suggested by recent studies in Drosophila. We used a multispecies approach to test this: Muller''s element D, an autosomal arm, is fused to the ancestral X chromosome in Drosophila pseudoobscura and its sister species, Drosophila affinis. We tested whether the same set of genes had higher rates of non-synonymous evolution when they were X-linked (in the D. pseudoobscura/D. affinis comparison) than when they were autosomal (in Drosophila melanogaster/Drosophila yakuba). Although not significant, our results suggest this may be the case, but only for genes under particularly strong positive selection/weak purifying selection. They also suggest that genes that have become X-linked have higher levels of codon bias and slower synonymous site evolution, consistent with more effective selection on codon usage at X-linked sites.' acknowledgement: B.V. was supported by the Portuguese Foundation for Science and Technology, P.R.H. is supported by the Natural Environmental Research Council (UK) and B.C. was supported by the Royal Society (UK) author: - first_name: Beatriz full_name: Beatriz Vicoso id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87 last_name: Vicoso orcid: 0000-0002-4579-8306 - first_name: Penelope full_name: Haddrill, Penelope R last_name: Haddrill - first_name: Brian full_name: Charlesworth, Brian last_name: Charlesworth citation: ama: Vicoso B, Haddrill P, Charlesworth B. A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila. Genetical Research. 2008;90(5):421-431. doi:10.1017/S0016672308009804 apa: Vicoso, B., Haddrill, P., & Charlesworth, B. (2008). A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila. Genetical Research. Cambridge University Press. https://doi.org/10.1017/S0016672308009804 chicago: Vicoso, Beatriz, Penelope Haddrill, and Brian Charlesworth. “A Multispecies Approach for Comparing Sequence Evolution of X-Linked and Autosomal Sites in Drosophila.” Genetical Research. Cambridge University Press, 2008. https://doi.org/10.1017/S0016672308009804. ieee: B. Vicoso, P. Haddrill, and B. Charlesworth, “A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila,” Genetical Research, vol. 90, no. 5. Cambridge University Press, pp. 421–431, 2008. ista: Vicoso B, Haddrill P, Charlesworth B. 2008. A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila. Genetical Research. 90(5), 421–431. mla: Vicoso, Beatriz, et al. “A Multispecies Approach for Comparing Sequence Evolution of X-Linked and Autosomal Sites in Drosophila.” Genetical Research, vol. 90, no. 5, Cambridge University Press, 2008, pp. 421–31, doi:10.1017/S0016672308009804. short: B. Vicoso, P. Haddrill, B. Charlesworth, Genetical Research 90 (2008) 421–431. date_created: 2018-12-11T11:55:30Z date_published: 2008-10-01T00:00:00Z date_updated: 2021-01-12T06:55:05Z day: '01' doi: 10.1017/S0016672308009804 extern: 1 intvolume: ' 90' issue: '5' month: '10' page: 421 - 431 publication: Genetical Research publication_status: published publisher: Cambridge University Press publist_id: '4972' quality_controlled: 0 status: public title: A multispecies approach for comparing sequence evolution of X-linked and autosomal sites in Drosophila type: journal_article volume: 90 year: '2008' ...