article published yes Emin Serin author Kerstin Ritter author Gunter Schumann author Tobias Banaschewski author Andre Marquand author Henrik Walter author George Ogoh author Bernd Carsten Stahl author Ragnhild Brandlistuen author Tamara Schikowski author Allan H. Young author Yu Xinyang author Zuo Zhang author Kofoworola Agunbiade author Di Chen author Sylvane Desrivières author Nicholas Clinton author Paul Thompson author Venessa Köhler author Ameli Schwalber author Vince D. Calhoun author Xiao Chang author Yanqing Zhang author Yuzhu Li author Yuxiang Dai author Jiacan Yuan author Yunman Xia author Tianye Jia author Paul Renner author Sören Hese author Bernhard Spanlang author Charlie Pearmund author Anastasios Polykarpos Athanasiadis author Spase Petkoski author Viktor Jirsa author Karen Schmitt author Johannes H. Wilbertz author Myrto Patraskaki author Peter Sommer author Stefanie Heilmann-Heimbach author Carina M. Mathey author Abigail J. Miller author Isabelle Claus author Markus M. Nöthen author Per Hoffmann author Andreas J. Forstner author Alvaro Pastor author Jaime Gallego author Reiya Itatani author Francisco Eiroa-Orosa author Guillem Feixas author Mel Slater author Gaia Novarino author 3E57A680-F248-11E8-B48F-1D18A9856A870000-0002-7673-7178 Sarah Jane Böttger author Mira Tschorn author Michael Rapp author Helga Ask author Rikka Kjelkenes author Sara Fernandez author Dennis Van Der Meer author Lars T. Westlye author Ole A. Andreassen author Rieke Aden author Beke Seefried author Frauke Nees author Maja Neidhart author Argyris Stringaris author Emanuel Schwarz author Nathalie Holz author Heike Tost author Andreas Meyer-Lindenberg author Nina Christmann author Karina Janson author Kerstin Schepanski author Tatjana Schütz author Ulrike Helene Taron author Roland Eils author Jean Charles Roy author Tristram A. Lett author Hedi Kebir author Elli Polemiti author Esther Hitchen author Marcel Jentsch author Emin Serin author Antoine Bernas author Nilakshi Vaidya author Sven Twardziok author Markus Ralser author Andreas Heinz author Gunter Schumann author GaNo department Task-based functional magnetic resonance imaging (fMRI) reveals individual differences in neural correlates of cognition but faces scalability challenges due to cognitive demands, protocol variability, and limited task coverage in large datasets. Here, we propose DeepTaskGen, a deep-learning approach that synthesizes non-acquired task-based contrast maps from resting-state (rs-) fMRI. We validate this approach using the Human Connectome Project lifespan data, then generate 47 contrast maps from 7 different cognitive tasks for over 20,000 individuals from UK Biobank. DeepTaskGen outperforms several benchmarks in generating synthetic task-contrast maps, achieving superior reconstruction performance while retaining inter-individual variation essential for biomarker development. We further show comparable or superior predictive performance of synthetic maps relative to actual maps and rs-connectomes across diverse demographic, cognitive, and clinical variables. This approach facilitates the study of individual differences and the generation of task-related biomarkers by enabling the generation of arbitrary functional cognitive tasks from readily available rs-fMRI data. https://research-explorer.ista.ac.at/download/20662/20675/2025_CommunicationsBiology_Serin.pdf application/pdfno Springer Nature2025 eng 2399-3642 41238730 00161446400000110.1038/s42003-025-09158-6 8 Serin, E., Ritter, K., Schumann, G., Banaschewski, T., Marquand, A., Walter, H., … Schumann, G. (2025). Generating synthetic task-based brain fingerprints for population neuroscience using deep learning. <i>Communications Biology</i>. Springer Nature. <a href="https://doi.org/10.1038/s42003-025-09158-6">https://doi.org/10.1038/s42003-025-09158-6</a> E. Serin, K. Ritter, G. Schumann, T. Banaschewski, A. Marquand, H. Walter, G. Ogoh, B.C. Stahl, R. Brandlistuen, T. Schikowski, A.H. Young, Y. Xinyang, Z. Zhang, K. Agunbiade, D. Chen, S. Desrivières, N. Clinton, P. Thompson, V. Köhler, A. Schwalber, V.D. Calhoun, X. Chang, Y. Zhang, Y. Li, Y. Dai, J. Yuan, Y. Xia, T. Jia, P. Renner, S. Hese, B. Spanlang, C. Pearmund, A.P. Athanasiadis, S. Petkoski, V. Jirsa, K. Schmitt, J.H. Wilbertz, M. Patraskaki, P. Sommer, S. Heilmann-Heimbach, C.M. Mathey, A.J. Miller, I. Claus, M.M. Nöthen, P. Hoffmann, A.J. Forstner, A. Pastor, J. Gallego, R. Itatani, F. Eiroa-Orosa, G. Feixas, M. Slater, G. Novarino, S.J. Böttger, M. Tschorn, M. Rapp, H. Ask, R. Kjelkenes, S. Fernandez, D. Van Der Meer, L.T. Westlye, O.A. Andreassen, R. Aden, B. Seefried, F. Nees, M. Neidhart, A. Stringaris, E. Schwarz, N. Holz, H. Tost, A. Meyer-Lindenberg, N. Christmann, K. Janson, K. Schepanski, T. Schütz, U.H. Taron, R. Eils, J.C. Roy, T.A. Lett, H. Kebir, E. Polemiti, E. Hitchen, M. Jentsch, E. Serin, A. Bernas, N. Vaidya, S. Twardziok, M. Ralser, A. Heinz, G. Schumann, Communications Biology 8 (2025). E. Serin <i>et al.</i>, “Generating synthetic task-based brain fingerprints for population neuroscience using deep learning,” <i>Communications Biology</i>, vol. 8. Springer Nature, 2025. Serin E, Ritter K, Schumann G, Banaschewski T, Marquand A, Walter H, Ogoh G, Stahl BC, Brandlistuen R, Schikowski T, Young AH, Xinyang Y, Zhang Z, Agunbiade K, Chen D, Desrivières S, Clinton N, Thompson P, Köhler V, Schwalber A, Calhoun VD, Chang X, Zhang Y, Li Y, Dai Y, Yuan J, Xia Y, Jia T, Renner P, Hese S, Spanlang B, Pearmund C, Athanasiadis AP, Petkoski S, Jirsa V, Schmitt K, Wilbertz JH, Patraskaki M, Sommer P, Heilmann-Heimbach S, Mathey CM, Miller AJ, Claus I, Nöthen MM, Hoffmann P, Forstner AJ, Pastor A, Gallego J, Itatani R, Eiroa-Orosa F, Feixas G, Slater M, Novarino G, Böttger SJ, Tschorn M, Rapp M, Ask H, Kjelkenes R, Fernandez S, Van Der Meer D, Westlye LT, Andreassen OA, Aden R, Seefried B, Nees F, Neidhart M, Stringaris A, Schwarz E, Holz N, Tost H, Meyer-Lindenberg A, Christmann N, Janson K, Schepanski K, Schütz T, Taron UH, Eils R, Roy JC, Lett TA, Kebir H, Polemiti E, Hitchen E, Jentsch M, Serin E, Bernas A, Vaidya N, Twardziok S, Ralser M, Heinz A, Schumann G. 2025. Generating synthetic task-based brain fingerprints for population neuroscience using deep learning. Communications Biology. 8, 1572. Serin, Emin, Kerstin Ritter, Gunter Schumann, Tobias Banaschewski, Andre Marquand, Henrik Walter, George Ogoh, et al. “Generating Synthetic Task-Based Brain Fingerprints for Population Neuroscience Using Deep Learning.” <i>Communications Biology</i>. Springer Nature, 2025. <a href="https://doi.org/10.1038/s42003-025-09158-6">https://doi.org/10.1038/s42003-025-09158-6</a>. Serin, Emin, et al. “Generating Synthetic Task-Based Brain Fingerprints for Population Neuroscience Using Deep Learning.” <i>Communications Biology</i>, vol. 8, 1572, Springer Nature, 2025, doi:<a href="https://doi.org/10.1038/s42003-025-09158-6">10.1038/s42003-025-09158-6</a>. Serin E, Ritter K, Schumann G, et al. Generating synthetic task-based brain fingerprints for population neuroscience using deep learning. <i>Communications Biology</i>. 2025;8. doi:<a href="https://doi.org/10.1038/s42003-025-09158-6">10.1038/s42003-025-09158-6</a> 206622025-11-23T23:01:38Z2025-12-01T15:24:07Z