---
res:
  bibo_abstract:
  - 'β-Barrel nanopores are involved in crucial biological processes, from ATP export
    in mitochondria to bacterial resistance, and represent a promising platform for
    emerging sequencing technologies. However, in contrast to ion channels, the understanding
    of the fundamental principles governing ion transport through these nanopores
    remains largely unexplored. Here we integrate experimental, numerical and theoretical
    approaches to elucidate ion transport mechanisms in β-barrel nanopores. We identify
    and characterize two distinct nonlinear phenomena: open-pore rectification and
    gating. Through extensive mutation analysis of aerolysin nanopores, we demonstrate
    that open-pore rectification is caused by ionic accumulation driven by the distribution
    of lumen charges. In addition, we provide converging evidence suggesting that
    gating is controlled by electric fields dissociating counterions from lumen charges,
    promoting local structural deformations. Our findings establish a rigorous framework
    for characterizing and understanding ion transport processes in protein-based
    nanopores, enabling the design of adaptable nanofluidic biotechnologies. We illustrate
    this by optimizing an aerolysin mutant for computing applications.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Mayer, Simon
      foaf_surname: Mayer
  - foaf_Person:
      foaf_givenName: Marianna Fanouria
      foaf_name: Mitsioni, Marianna Fanouria
      foaf_surname: Mitsioni
  - foaf_Person:
      foaf_givenName: Paul
      foaf_name: Robin, Paul
      foaf_surname: Robin
      foaf_workInfoHomepage: http://www.librecat.org/personId=48c58128-57b0-11ee-9095-dc28fd97fc1d
    orcid: 0000-0002-5728-9189
  - foaf_Person:
      foaf_givenName: Lukas
      foaf_name: Van Den Heuvel, Lukas
      foaf_surname: Van Den Heuvel
  - foaf_Person:
      foaf_givenName: Nathan
      foaf_name: Ronceray, Nathan
      foaf_surname: Ronceray
  - foaf_Person:
      foaf_givenName: Maria Jose
      foaf_name: Marcaida, Maria Jose
      foaf_surname: Marcaida
  - foaf_Person:
      foaf_givenName: Luciano A.
      foaf_name: Abriata, Luciano A.
      foaf_surname: Abriata
  - foaf_Person:
      foaf_givenName: Lucien F.
      foaf_name: Krapp, Lucien F.
      foaf_surname: Krapp
  - foaf_Person:
      foaf_givenName: Jana S.
      foaf_name: Anton, Jana S.
      foaf_surname: Anton
  - foaf_Person:
      foaf_givenName: Sarah
      foaf_name: Soussou, Sarah
      foaf_surname: Soussou
  - foaf_Person:
      foaf_givenName: Justin
      foaf_name: Jeanneret-Grosjean, Justin
      foaf_surname: Jeanneret-Grosjean
  - foaf_Person:
      foaf_givenName: Alessandro
      foaf_name: Fulciniti, Alessandro
      foaf_surname: Fulciniti
  - foaf_Person:
      foaf_givenName: Alexia
      foaf_name: Möller, Alexia
      foaf_surname: Möller
  - foaf_Person:
      foaf_givenName: Sarah
      foaf_name: Vacle, Sarah
      foaf_surname: Vacle
  - foaf_Person:
      foaf_givenName: Lely
      foaf_name: Feletti, Lely
      foaf_surname: Feletti
  - foaf_Person:
      foaf_givenName: Henry
      foaf_name: Brinkerhoff, Henry
      foaf_surname: Brinkerhoff
  - foaf_Person:
      foaf_givenName: Andrew H.
      foaf_name: Laszlo, Andrew H.
      foaf_surname: Laszlo
  - foaf_Person:
      foaf_givenName: Jens H.
      foaf_name: Gundlach, Jens H.
      foaf_surname: Gundlach
  - foaf_Person:
      foaf_givenName: Theo
      foaf_name: Emmerich, Theo
      foaf_surname: Emmerich
  - foaf_Person:
      foaf_givenName: Matteo
      foaf_name: Dal Peraro, Matteo
      foaf_surname: Dal Peraro
  - foaf_Person:
      foaf_givenName: Aleksandra
      foaf_name: Radenovic, Aleksandra
      foaf_surname: Radenovic
  bibo_doi: 10.1038/s41565-025-02052-6
  dct_date: 2025^xs_gYear
  dct_identifier:
  - UT:001611698900001
  dct_isPartOf:
  - http://id.crossref.org/issn/1748-3387
  - http://id.crossref.org/issn/1748-3395
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Lumen charge governs gated ion transport in β-barrel nanopores@
  fabio_hasPubmedId: '41219410'
...