---
_id: '2072'
abstract:
- lang: eng
text: Many species have morphologically and genetically differentiated sex chromosomes,
such as the XY pair of mammals. Y chromosomes are often highly degenerated and
carry few functional genes, so that XY males have only one copy of most Xlinked
genes (whereas females have two). As a result, chromosome-wide mechanisms of dosage
compensation, such as the mammalian X-inactivation, often evolve to reestablish
expression balance. A similar phenomenon is expected in femaleheterogametic species,
where ZW females should suffer from imbalances due to W-chromosome degeneration.
However, no global dosage compensation mechanisms have been detected in the two
independent ZW systems that have been studied systematically (birds and silkworm),
leading to the suggestion that lack of global dosage compensation may be a general
feature of female-heterogametic species. However, analyses of other independently
evolved ZW systems are required to test if this is the case. In this study, we
use published genomic and expression data to test for the presence of global dosage
compensation in Schistosoma mansoni, a trematode parasite that causes schistosomiasis
in humans. We find that Z-linked expression is reduced relative to autosomal expression
in females but not males, consistent with incomplete or localized dosage compensation.
This gives further support to the theory that female-heterogametic species may
not require global mechanisms of dosage compensation.
author:
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
- first_name: Doris
full_name: Bachtrog, Doris
last_name: Bachtrog
citation:
ama: Vicoso B, Bachtrog D. Lack of global dosage compensation in Schistosoma mansoni,
a female-heterogametic parasite. Genome Biology and Evolution. 2011;3(1):230-235.
doi:10.1093/gbe/evr010
apa: Vicoso, B., & Bachtrog, D. (2011). Lack of global dosage compensation in
Schistosoma mansoni, a female-heterogametic parasite. Genome Biology and Evolution.
Oxford University Press. https://doi.org/10.1093/gbe/evr010
chicago: Vicoso, Beatriz, and Doris Bachtrog. “Lack of Global Dosage Compensation
in Schistosoma Mansoni, a Female-Heterogametic Parasite.” Genome Biology and
Evolution. Oxford University Press, 2011. https://doi.org/10.1093/gbe/evr010.
ieee: B. Vicoso and D. Bachtrog, “Lack of global dosage compensation in Schistosoma
mansoni, a female-heterogametic parasite,” Genome Biology and Evolution,
vol. 3, no. 1. Oxford University Press, pp. 230–235, 2011.
ista: Vicoso B, Bachtrog D. 2011. Lack of global dosage compensation in Schistosoma
mansoni, a female-heterogametic parasite. Genome Biology and Evolution. 3(1),
230–235.
mla: Vicoso, Beatriz, and Doris Bachtrog. “Lack of Global Dosage Compensation in
Schistosoma Mansoni, a Female-Heterogametic Parasite.” Genome Biology and Evolution,
vol. 3, no. 1, Oxford University Press, 2011, pp. 230–35, doi:10.1093/gbe/evr010.
short: B. Vicoso, D. Bachtrog, Genome Biology and Evolution 3 (2011) 230–235.
date_created: 2018-12-11T11:55:33Z
date_published: 2011-02-11T00:00:00Z
date_updated: 2021-01-12T06:55:08Z
day: '11'
ddc:
- '570'
doi: 10.1093/gbe/evr010
extern: '1'
file:
- access_level: open_access
checksum: 7855c134436e4f6a13d63b6606d7e8dd
content_type: application/pdf
creator: dernst
date_created: 2019-05-10T07:41:28Z
date_updated: 2020-07-14T12:45:27Z
file_id: '6395'
file_name: 2011_GBE_Vicoso.pdf
file_size: 212547
relation: main_file
file_date_updated: 2020-07-14T12:45:27Z
has_accepted_license: '1'
intvolume: ' 3'
issue: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '02'
oa: 1
oa_version: Published Version
page: 230 - 235
publication: Genome Biology and Evolution
publication_status: published
publisher: Oxford University Press
publist_id: '4966'
quality_controlled: '1'
status: public
title: Lack of global dosage compensation in Schistosoma mansoni, a female-heterogametic
parasite
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2011'
...