--- _id: '2072' abstract: - lang: eng text: Many species have morphologically and genetically differentiated sex chromosomes, such as the XY pair of mammals. Y chromosomes are often highly degenerated and carry few functional genes, so that XY males have only one copy of most Xlinked genes (whereas females have two). As a result, chromosome-wide mechanisms of dosage compensation, such as the mammalian X-inactivation, often evolve to reestablish expression balance. A similar phenomenon is expected in femaleheterogametic species, where ZW females should suffer from imbalances due to W-chromosome degeneration. However, no global dosage compensation mechanisms have been detected in the two independent ZW systems that have been studied systematically (birds and silkworm), leading to the suggestion that lack of global dosage compensation may be a general feature of female-heterogametic species. However, analyses of other independently evolved ZW systems are required to test if this is the case. In this study, we use published genomic and expression data to test for the presence of global dosage compensation in Schistosoma mansoni, a trematode parasite that causes schistosomiasis in humans. We find that Z-linked expression is reduced relative to autosomal expression in females but not males, consistent with incomplete or localized dosage compensation. This gives further support to the theory that female-heterogametic species may not require global mechanisms of dosage compensation. author: - first_name: Beatriz full_name: Vicoso, Beatriz id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87 last_name: Vicoso orcid: 0000-0002-4579-8306 - first_name: Doris full_name: Bachtrog, Doris last_name: Bachtrog citation: ama: Vicoso B, Bachtrog D. Lack of global dosage compensation in Schistosoma mansoni, a female-heterogametic parasite. Genome Biology and Evolution. 2011;3(1):230-235. doi:10.1093/gbe/evr010 apa: Vicoso, B., & Bachtrog, D. (2011). Lack of global dosage compensation in Schistosoma mansoni, a female-heterogametic parasite. Genome Biology and Evolution. Oxford University Press. https://doi.org/10.1093/gbe/evr010 chicago: Vicoso, Beatriz, and Doris Bachtrog. “Lack of Global Dosage Compensation in Schistosoma Mansoni, a Female-Heterogametic Parasite.” Genome Biology and Evolution. Oxford University Press, 2011. https://doi.org/10.1093/gbe/evr010. ieee: B. Vicoso and D. Bachtrog, “Lack of global dosage compensation in Schistosoma mansoni, a female-heterogametic parasite,” Genome Biology and Evolution, vol. 3, no. 1. Oxford University Press, pp. 230–235, 2011. ista: Vicoso B, Bachtrog D. 2011. Lack of global dosage compensation in Schistosoma mansoni, a female-heterogametic parasite. Genome Biology and Evolution. 3(1), 230–235. mla: Vicoso, Beatriz, and Doris Bachtrog. “Lack of Global Dosage Compensation in Schistosoma Mansoni, a Female-Heterogametic Parasite.” Genome Biology and Evolution, vol. 3, no. 1, Oxford University Press, 2011, pp. 230–35, doi:10.1093/gbe/evr010. short: B. Vicoso, D. Bachtrog, Genome Biology and Evolution 3 (2011) 230–235. date_created: 2018-12-11T11:55:33Z date_published: 2011-02-11T00:00:00Z date_updated: 2021-01-12T06:55:08Z day: '11' ddc: - '570' doi: 10.1093/gbe/evr010 extern: '1' file: - access_level: open_access checksum: 7855c134436e4f6a13d63b6606d7e8dd content_type: application/pdf creator: dernst date_created: 2019-05-10T07:41:28Z date_updated: 2020-07-14T12:45:27Z file_id: '6395' file_name: 2011_GBE_Vicoso.pdf file_size: 212547 relation: main_file file_date_updated: 2020-07-14T12:45:27Z has_accepted_license: '1' intvolume: ' 3' issue: '1' language: - iso: eng license: https://creativecommons.org/licenses/by-nc/4.0/ month: '02' oa: 1 oa_version: Published Version page: 230 - 235 publication: Genome Biology and Evolution publication_status: published publisher: Oxford University Press publist_id: '4966' quality_controlled: '1' status: public title: Lack of global dosage compensation in Schistosoma mansoni, a female-heterogametic parasite tmp: image: /images/cc_by_nc.png legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) short: CC BY-NC (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 3 year: '2011' ...