--- res: bibo_abstract: - 'Background: Drosophila albomicans is a unique model organism for studying both sex chromosome and B chromosome evolution. A pair of its autosomes comprising roughly 40% of the whole genome has fused to the ancient X and Y chromosomes only about 0.12 million years ago, thereby creating the youngest and most gene-rich neo-sex system reported to date. This species also possesses recently derived B chromosomes that show non-Mendelian inheritance and significantly influence fertility.Methods: We sequenced male flies with B chromosomes at 124.5-fold genome coverage using next-generation sequencing. To characterize neo-Y specific changes and B chromosome sequences, we also sequenced inbred female flies derived from the same strain but without B''s at 28.5-fold.Results: We assembled a female genome and placed 53% of the sequence and 85% of the annotated proteins into specific chromosomes, by comparison with the 12 Drosophila genomes. Despite its very recent origin, the non-recombining neo-Y chromosome shows various signs of degeneration, including a significant enrichment of non-functional genes compared to the neo-X, and an excess of tandem duplications relative to other chromosomes. We also characterized a B-chromosome linked scaffold that contains an actively transcribed unit and shows sequence similarity to the subcentromeric regions of both the ancient X and the neo-X chromosome.Conclusions: Our results provide novel insights into the very early stages of sex chromosome evolution and B chromosome origination, and suggest an unprecedented connection between the births of these two systems in D. albomicans.@eng' bibo_authorlist: - foaf_Person: foaf_givenName: Qi foaf_name: Zhou, Qi foaf_surname: Zhou - foaf_Person: foaf_givenName: Hongmei foaf_name: Zhu, Hongmei foaf_surname: Zhu - foaf_Person: foaf_givenName: Quanfei foaf_name: Huang, Quanfei foaf_surname: Huang - foaf_Person: foaf_givenName: Li foaf_name: Zhao, Li foaf_surname: Zhao - foaf_Person: foaf_givenName: Guo foaf_name: Zhang, Guo J foaf_surname: Zhang - foaf_Person: foaf_givenName: Scott foaf_name: Roy, Scott W foaf_surname: Roy - foaf_Person: foaf_givenName: Beatriz foaf_name: Beatriz Vicoso foaf_surname: Vicoso foaf_workInfoHomepage: http://www.librecat.org/personId=49E1C5C6-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-4579-8306 - foaf_Person: foaf_givenName: Zhaolin foaf_name: Xuan, Zhaolin foaf_surname: Xuan - foaf_Person: foaf_givenName: Jue foaf_name: Ruan, Jue foaf_surname: Ruan - foaf_Person: foaf_givenName: Yue foaf_name: Zhang, Yue foaf_surname: Zhang - foaf_Person: foaf_givenName: Ruoping foaf_name: Zhao, Ruoping foaf_surname: Zhao - foaf_Person: foaf_givenName: Chen foaf_name: Ye, Chen foaf_surname: Ye - foaf_Person: foaf_givenName: Xiuqing foaf_name: Zhang, Xiuqing foaf_surname: Zhang - foaf_Person: foaf_givenName: Jùn foaf_name: Wang, Jùn foaf_surname: Wang - foaf_Person: foaf_givenName: Wen foaf_name: Wang, Wen foaf_surname: Wang - foaf_Person: foaf_givenName: Doris foaf_name: Bachtrog, Doris foaf_surname: Bachtrog bibo_doi: 10.1186/1471-2164-13-109 bibo_issue: '1' bibo_volume: 13 dct_date: 2012^xs_gYear dct_publisher: BioMed Central@ dct_title: Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans@ ...