---
_id: '2073'
abstract:
- lang: eng
  text: 'Background: Drosophila albomicans is a unique model organism for studying
    both sex chromosome and B chromosome evolution. A pair of its autosomes comprising
    roughly 40% of the whole genome has fused to the ancient X and Y chromosomes only
    about 0.12 million years ago, thereby creating the youngest and most gene-rich
    neo-sex system reported to date. This species also possesses recently derived
    B chromosomes that show non-Mendelian inheritance and significantly influence
    fertility.Methods: We sequenced male flies with B chromosomes at 124.5-fold genome
    coverage using next-generation sequencing. To characterize neo-Y specific changes
    and B chromosome sequences, we also sequenced inbred female flies derived from
    the same strain but without B''s at 28.5-fold.Results: We assembled a female genome
    and placed 53% of the sequence and 85% of the annotated proteins into specific
    chromosomes, by comparison with the 12 Drosophila genomes. Despite its very recent
    origin, the non-recombining neo-Y chromosome shows various signs of degeneration,
    including a significant enrichment of non-functional genes compared to the neo-X,
    and an excess of tandem duplications relative to other chromosomes. We also characterized
    a B-chromosome linked scaffold that contains an actively transcribed unit and
    shows sequence similarity to the subcentromeric regions of both the ancient X
    and the neo-X chromosome.Conclusions: Our results provide novel insights into
    the very early stages of sex chromosome evolution and B chromosome origination,
    and suggest an unprecedented connection between the births of these two systems
    in D. albomicans.'
author:
- first_name: Qi
  full_name: Zhou, Qi
  last_name: Zhou
- first_name: Hongmei
  full_name: Zhu, Hongmei
  last_name: Zhu
- first_name: Quanfei
  full_name: Huang, Quanfei
  last_name: Huang
- first_name: Li
  full_name: Zhao, Li
  last_name: Zhao
- first_name: Guo
  full_name: Zhang, Guo J
  last_name: Zhang
- first_name: Scott
  full_name: Roy, Scott W
  last_name: Roy
- first_name: Beatriz
  full_name: Beatriz Vicoso
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
- first_name: Zhaolin
  full_name: Xuan, Zhaolin
  last_name: Xuan
- first_name: Jue
  full_name: Ruan, Jue
  last_name: Ruan
- first_name: Yue
  full_name: Zhang, Yue
  last_name: Zhang
- first_name: Ruoping
  full_name: Zhao, Ruoping
  last_name: Zhao
- first_name: Chen
  full_name: Ye, Chen
  last_name: Ye
- first_name: Xiuqing
  full_name: Zhang, Xiuqing
  last_name: Zhang
- first_name: Jùn
  full_name: Wang, Jùn
  last_name: Wang
- first_name: Wen
  full_name: Wang, Wen
  last_name: Wang
- first_name: Doris
  full_name: Bachtrog, Doris
  last_name: Bachtrog
citation:
  ama: Zhou Q, Zhu H, Huang Q, et al. Deciphering neo-sex and B chromosome evolution
    by the draft genome of Drosophila albomicans. <i>BMC Genomics</i>. 2012;13(1).
    doi:<a href="https://doi.org/10.1186/1471-2164-13-109">10.1186/1471-2164-13-109</a>
  apa: Zhou, Q., Zhu, H., Huang, Q., Zhao, L., Zhang, G., Roy, S., … Bachtrog, D.
    (2012). Deciphering neo-sex and B chromosome evolution by the draft genome of
    Drosophila albomicans. <i>BMC Genomics</i>. BioMed Central. <a href="https://doi.org/10.1186/1471-2164-13-109">https://doi.org/10.1186/1471-2164-13-109</a>
  chicago: Zhou, Qi, Hongmei Zhu, Quanfei Huang, Li Zhao, Guo Zhang, Scott Roy, Beatriz
    Vicoso, et al. “Deciphering Neo-Sex and B Chromosome Evolution by the Draft Genome
    of Drosophila Albomicans.” <i>BMC Genomics</i>. BioMed Central, 2012. <a href="https://doi.org/10.1186/1471-2164-13-109">https://doi.org/10.1186/1471-2164-13-109</a>.
  ieee: Q. Zhou <i>et al.</i>, “Deciphering neo-sex and B chromosome evolution by
    the draft genome of Drosophila albomicans,” <i>BMC Genomics</i>, vol. 13, no.
    1. BioMed Central, 2012.
  ista: Zhou Q, Zhu H, Huang Q, Zhao L, Zhang G, Roy S, Vicoso B, Xuan Z, Ruan J,
    Zhang Y, Zhao R, Ye C, Zhang X, Wang J, Wang W, Bachtrog D. 2012. Deciphering
    neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans.
    BMC Genomics. 13(1).
  mla: Zhou, Qi, et al. “Deciphering Neo-Sex and B Chromosome Evolution by the Draft
    Genome of Drosophila Albomicans.” <i>BMC Genomics</i>, vol. 13, no. 1, BioMed
    Central, 2012, doi:<a href="https://doi.org/10.1186/1471-2164-13-109">10.1186/1471-2164-13-109</a>.
  short: Q. Zhou, H. Zhu, Q. Huang, L. Zhao, G. Zhang, S. Roy, B. Vicoso, Z. Xuan,
    J. Ruan, Y. Zhang, R. Zhao, C. Ye, X. Zhang, J. Wang, W. Wang, D. Bachtrog, BMC
    Genomics 13 (2012).
date_created: 2018-12-11T11:55:33Z
date_published: 2012-03-22T00:00:00Z
date_updated: 2021-01-12T06:55:08Z
day: '22'
doi: 10.1186/1471-2164-13-109
extern: 1
fulldoi: https://doi.org/10.1186/1471-2164-13-109
intvolume: '        13'
issue: '1'
license: https://creativecommons.org/licenses/by/4.0/
month: '03'
publication: BMC Genomics
publication_status: published
publisher: BioMed Central
publist_id: '4965'
quality_controlled: 0
status: public
title: Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila
  albomicans
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
volume: 13
year: '2012'
...