{"department":[{"_id":"GaNo"}],"file":[{"file_id":"20745","content_type":"application/pdf","success":1,"file_name":"2025_AnnualRevGenetics_Marano.pdf","creator":"dernst","relation":"main_file","access_level":"open_access","file_size":3629986,"date_created":"2025-12-09T12:53:09Z","date_updated":"2025-12-09T12:53:09Z","checksum":"1000228dc9aca3d48e92605607a99c41"}],"tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"pmid":1,"day":"03","external_id":{"pmid":["40902207"]},"_id":"20731","publication_status":"published","year":"2025","date_created":"2025-12-07T23:02:01Z","title":"Fueling the mind: Brain metabolism in health and neurodevelopmental disorders","oa_version":"Published Version","publisher":"Annual Reviews","OA_place":"publisher","page":"415-434","language":[{"iso":"eng"}],"has_accepted_license":"1","OA_type":"hybrid","corr_author":"1","project":[{"name":"Reducing the impact of major environmental challenges on mental health","grant_number":"101057429","_id":"349d1832-11ca-11ed-8bc3-d79b574010e0"}],"doi":"10.1146/annurev-genet-111523-102424","citation":{"ieee":"D. Marano, V. Mariano, and G. Novarino, “Fueling the mind: Brain metabolism in health and neurodevelopmental disorders,” <i>Annual Review of Genetics</i>, vol. 59. Annual Reviews, pp. 415–434, 2025.","short":"D. Marano, V. Mariano, G. Novarino, Annual Review of Genetics 59 (2025) 415–434.","ama":"Marano D, Mariano V, Novarino G. Fueling the mind: Brain metabolism in health and neurodevelopmental disorders. <i>Annual Review of Genetics</i>. 2025;59:415-434. doi:<a href=\"https://doi.org/10.1146/annurev-genet-111523-102424\">10.1146/annurev-genet-111523-102424</a>","apa":"Marano, D., Mariano, V., &#38; Novarino, G. (2025). Fueling the mind: Brain metabolism in health and neurodevelopmental disorders. <i>Annual Review of Genetics</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev-genet-111523-102424\">https://doi.org/10.1146/annurev-genet-111523-102424</a>","mla":"Marano, Domenico, et al. “Fueling the Mind: Brain Metabolism in Health and Neurodevelopmental Disorders.” <i>Annual Review of Genetics</i>, vol. 59, Annual Reviews, 2025, pp. 415–34, doi:<a href=\"https://doi.org/10.1146/annurev-genet-111523-102424\">10.1146/annurev-genet-111523-102424</a>.","chicago":"Marano, Domenico, Vittoria Mariano, and Gaia Novarino. “Fueling the Mind: Brain Metabolism in Health and Neurodevelopmental Disorders.” <i>Annual Review of Genetics</i>. Annual Reviews, 2025. <a href=\"https://doi.org/10.1146/annurev-genet-111523-102424\">https://doi.org/10.1146/annurev-genet-111523-102424</a>.","ista":"Marano D, Mariano V, Novarino G. 2025. Fueling the mind: Brain metabolism in health and neurodevelopmental disorders. Annual Review of Genetics. 59, 415–434."},"quality_controlled":"1","date_published":"2025-11-03T00:00:00Z","file_date_updated":"2025-12-09T12:53:09Z","month":"11","PlanS_conform":"1","license":"https://creativecommons.org/licenses/by/4.0/","publication_identifier":{"issn":["0066-4197"],"eissn":["1545-2948"]},"oa":1,"article_type":"review","status":"public","intvolume":"        59","volume":59,"type":"journal_article","ddc":["570"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","date_updated":"2025-12-09T12:55:11Z","author":[{"first_name":"Domenico","last_name":"Marano","full_name":"Marano, Domenico","id":"3b004c42-803f-11ed-ab7e-ecee8f08bd58"},{"last_name":"Mariano","first_name":"Vittoria","id":"ee829c33-edb3-11ed-b4fb-c020aaca4b01","full_name":"Mariano, Vittoria"},{"full_name":"Novarino, Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","first_name":"Gaia","last_name":"Novarino"}],"publication":"Annual Review of Genetics","abstract":[{"lang":"eng","text":"The adult human brain, under resting conditions, consumes approximately 20% of total body glucose, a demand that is even higher during the first decade of life. The brain metabolic landscape is intricately regulated throughout development, and each cell type exhibits distinct metabolic signatures at each specific stage. This picture becomes even more intricate when considering that metabolism is dynamically modulated to sustain critical biological processes, such as cell proliferation and differentiation and synaptic activity–dependent processes. The orchestration between metabolic regulation and the aforementioned physiological processes often relies on metabolism-dependent changes in the epigenetic landscape, which shape gene expression patterns to trigger selected downstream biological responses. Perturbations of brain metabolic pathways are frequently the cause of severe neurodevelopmental disorders. This review explores the latest insights into the regulation of brain metabolism in health and disease."}],"acknowledgement":"Funding provided by the European Union (grant 101057429) to G.N.","article_processing_charge":"Yes (in subscription journal)"}