{"year":"2025","title":"Causes and consequences of sex-chromosome turnovers in Diptera","_id":"20780","author":[{"id":"02814589-eb8f-11eb-b029-a70074f3f18f","last_name":"Layana Franco","full_name":"Layana Franco, Lorena Alexandra","orcid":"0000-0002-1253-6297","first_name":"Lorena Alexandra"},{"id":"4E099E4E-F248-11E8-B48F-1D18A9856A87","full_name":"Toups, Melissa A","first_name":"Melissa A","orcid":"0000-0002-9752-7380","last_name":"Toups"},{"last_name":"Vicoso","first_name":"Beatriz","orcid":"0000-0002-4579-8306","full_name":"Vicoso, Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87"}],"month":"12","file":[{"date_created":"2025-12-11T10:47:15Z","access_level":"open_access","content_type":"application/zip","file_id":"20799","checksum":"251e7aab01917c2ad2fbccf465492ea1","success":1,"file_name":"Perl_scripts.zip","date_updated":"2025-12-11T10:47:15Z","relation":"main_file","file_size":4575,"creator":"llayanaf"},{"file_id":"20800","content_type":"application/zip","access_level":"open_access","date_created":"2025-12-11T10:52:17Z","relation":"main_file","file_size":19052849,"date_updated":"2025-12-11T10:52:17Z","creator":"llayanaf","checksum":"daf1c03149dd170b14e5c8e109ee3c77","file_name":"Supplementary_Datasets.zip","success":1},{"checksum":"658d6e95a361b0a3db058b7b4e1733d4","success":1,"file_name":"Supplementary_Tables.zip","date_updated":"2025-12-11T10:52:11Z","relation":"main_file","file_size":566476,"creator":"llayanaf","date_created":"2025-12-11T10:52:11Z","access_level":"open_access","content_type":"application/zip","file_id":"20801"},{"file_name":"README.txt","success":1,"checksum":"2a2b92eb9fade0015719190596a8c5b7","creator":"llayanaf","file_size":1204,"relation":"main_file","date_updated":"2025-12-11T11:00:53Z","date_created":"2025-12-11T11:00:53Z","access_level":"open_access","file_id":"20802","content_type":"text/plain"}],"date_updated":"2025-12-15T11:13:32Z","has_accepted_license":"1","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","abstract":[{"text":"Sex-chromosome systems are highly variable across animals, but how they transition from one to another is not well understood. Diptera have undergone multiple sex-chromosome turnovers and expansions while maintaining their general chromosomal content, which makes them an ideal clade to study such transitions. We analysed more than 100 dipteran whole-genome assemblies and identified 4 new lineages that underwent sex-chromosome turnover (in addition to the 5 previously reported). We find the majority of turnovers happened in the group Schizophora, which tend to have fewer genes on the F element (the chromosome homologous to the ancestral insect X chromosome) than lower dipterans, a factor previously hypothesized to facilitate turnover. Most derived X chromosomes have higher GC content than autosomes, consistent with a high prevalence of male-achiasmy in Diptera. In addition, an excess of gene movement out of the X is detected for most of these new X chromosomes, and many of these moved genes have high testis expression in Drosophila, suggesting that out-of-X gene movement contributes to the long-term demasculinization of X chromosomes.","lang":"eng"}],"corr_author":"1","keyword":["Schizophora","sex chromosomes","sex-chromosome turnover","Diptera","genomic features","out-of-X movement."],"acknowledged_ssus":[{"_id":"ScienComp"}],"publisher":"Institute of Science and Technology Austria","oa":1,"article_processing_charge":"No","status":"public","date_created":"2025-12-10T23:40:14Z","doi":"10.15479/AT-ISTA-20780","file_date_updated":"2025-12-11T11:00:53Z","citation":{"ista":"Layana Franco LA, Toups MA, Vicoso B. 2025. Causes and consequences of sex-chromosome turnovers in Diptera, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-20780\">10.15479/AT-ISTA-20780</a>.","apa":"Layana Franco, L. A., Toups, M. A., &#38; Vicoso, B. (2025). Causes and consequences of sex-chromosome turnovers in Diptera. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20780\">https://doi.org/10.15479/AT-ISTA-20780</a>","chicago":"Layana Franco, Lorena Alexandra, Melissa A Toups, and Beatriz Vicoso. “Causes and Consequences of Sex-Chromosome Turnovers in Diptera.” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20780\">https://doi.org/10.15479/AT-ISTA-20780</a>.","short":"L.A. Layana Franco, M.A. Toups, B. Vicoso, (2025).","ama":"Layana Franco LA, Toups MA, Vicoso B. Causes and consequences of sex-chromosome turnovers in Diptera. 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20780\">10.15479/AT-ISTA-20780</a>","mla":"Layana Franco, Lorena Alexandra, et al. <i>Causes and Consequences of Sex-Chromosome Turnovers in Diptera</i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20780\">10.15479/AT-ISTA-20780</a>.","ieee":"L. A. Layana Franco, M. A. Toups, and B. Vicoso, “Causes and consequences of sex-chromosome turnovers in Diptera.” Institute of Science and Technology Austria, 2025."},"date_published":"2025-12-01T00:00:00Z","type":"research_data","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"department":[{"_id":"BeVi"}],"oa_version":"None"}