{"volume":13,"date_updated":"2025-12-15T10:26:56Z","publication":"eLife","external_id":{"pmid":["39028260"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"19","year":"2024","OA_place":"publisher","author":[{"id":"25f3131f-6e7c-11ef-8296-b64ccd4a1b69","last_name":"Knop","full_name":"Knop, Filip","orcid":"0000-0002-3845-3465","first_name":"Filip"},{"last_name":"Zounarová","full_name":"Zounarová, Apolena","first_name":"Apolena"},{"last_name":"Šabata","full_name":"Šabata, Vojtěch","first_name":"Vojtěch"},{"last_name":"Middelkoop","full_name":"Middelkoop, Teije Corneel","first_name":"Teije Corneel"},{"first_name":"Marie","full_name":"Macůrková, Marie","last_name":"Macůrková"}],"month":"07","citation":{"apa":"Knop, F., Zounarová, A., Šabata, V., Middelkoop, T. C., &#38; Macůrková, M. (2024). Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/elife.91054\">https://doi.org/10.7554/elife.91054</a>","chicago":"Knop, Filip, Apolena Zounarová, Vojtěch Šabata, Teije Corneel Middelkoop, and Marie Macůrková. “Caenorhabditis Elegans SEL-5/AAK1 Regulates Cell Migration and Cell Outgrowth Independently of Its Kinase Activity.” <i>ELife</i>. eLife Sciences Publications, 2024. <a href=\"https://doi.org/10.7554/elife.91054\">https://doi.org/10.7554/elife.91054</a>.","ama":"Knop F, Zounarová A, Šabata V, Middelkoop TC, Macůrková M. Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity. <i>eLife</i>. 2024;13. doi:<a href=\"https://doi.org/10.7554/elife.91054\">10.7554/elife.91054</a>","short":"F. Knop, A. Zounarová, V. Šabata, T.C. Middelkoop, M. Macůrková, ELife 13 (2024).","ista":"Knop F, Zounarová A, Šabata V, Middelkoop TC, Macůrková M. 2024. Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity. eLife. 13, e91054.","ieee":"F. Knop, A. Zounarová, V. Šabata, T. C. Middelkoop, and M. Macůrková, “Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity,” <i>eLife</i>, vol. 13. eLife Sciences Publications, 2024.","mla":"Knop, Filip, et al. “Caenorhabditis Elegans SEL-5/AAK1 Regulates Cell Migration and Cell Outgrowth Independently of Its Kinase Activity.” <i>ELife</i>, vol. 13, e91054, eLife Sciences Publications, 2024, doi:<a href=\"https://doi.org/10.7554/elife.91054\">10.7554/elife.91054</a>."},"oa_version":"Published Version","type":"journal_article","date_published":"2024-07-19T00:00:00Z","OA_type":"gold","extern":"1","main_file_link":[{"url":"https://doi.org/10.7554/elife.91054","open_access":"1"}],"article_processing_charge":"Yes","status":"public","intvolume":"        13","quality_controlled":"1","publication_identifier":{"eissn":["2050-084X"]},"abstract":[{"lang":"eng","text":"During Caenorhabditis elegans development, multiple cells migrate long distances or extend processes to reach their final position and/or attain proper shape. The Wnt signalling pathway stands out as one of the major coordinators of cell migration or cell outgrowth along the anterior-posterior body axis. The outcome of Wnt signalling is fine-tuned by various mechanisms including endocytosis. In this study, we show that SEL-5, the C. elegans orthologue of mammalian AP2-associated kinase AAK1, acts together with the retromer complex as a positive regulator of EGL-20/Wnt signalling during the migration of QL neuroblast daughter cells. At the same time, SEL-5 in cooperation with the retromer complex is also required during excretory canal cell outgrowth. Importantly, SEL-5 kinase activity is not required for its role in neuronal migration or excretory cell outgrowth, and neither of these processes is dependent on DPY-23/AP2M1 phosphorylation. We further establish that the Wnt proteins CWN-1 and CWN-2, together with the Frizzled receptor CFZ-2, positively regulate excretory cell outgrowth, while LIN-44/Wnt and LIN-17/Frizzled together generate a stop signal inhibiting its extension."}],"pmid":1,"language":[{"iso":"eng"}],"_id":"20808","title":"Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity","article_number":"e91054","article_type":"original","scopus_import":"1","publication_status":"published","DOAJ_listed":"1","oa":1,"publisher":"eLife Sciences Publications","doi":"10.7554/elife.91054","date_created":"2025-12-12T09:06:31Z"}