[{"publisher":"Institute of Science and Technology Austria","abstract":[{"lang":"eng","text":"Sex-chromosome systems are highly variable across animals, but how they transition from one to another is not well understood. Diptera have undergone multiple sex-chromosome turnovers and expansions while maintaining their general chromosomal content, which makes them an ideal clade to study such transitions. We analysed more than 100 dipteran whole-genome assemblies and identified 4 new lineages that underwent sex-chromosome turnover (in addition to the 5 previously reported). We find the majority of turnovers happened in the group Schizophora, which tend to have fewer genes on the F element (the chromosome homologous to the ancestral insect X chromosome) than lower dipterans, a factor previously hypothesized to facilitate turnover. Most derived X chromosomes have higher GC content than autosomes, consistent with a high prevalence of male-achiasmy in Diptera. In addition, an excess of gene movement out of the X is detected for most of these new X chromosomes, and many of these moved genes have high testis expression in Drosophila, suggesting that out-of-X gene movement contributes to the long-term demasculinization of X chromosomes."}],"date_created":"2025-12-17T10:10:57Z","title":"Research Data for 'Causes and consequences of sex-chromosome turnovers in Diptera'","article_processing_charge":"No","_id":"20833","file_date_updated":"2026-01-08T01:35:08Z","month":"01","oa_version":"Published Version","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"oa":1,"date_updated":"2026-06-10T09:21:49Z","day":"8","type":"research_data","license":"https://creativecommons.org/licenses/by/4.0/","fulldoi":"https://doi.org/10.15479/AT-ISTA-20833","keyword":["Schizophora","sex chromosomes","sex-chromosome turnover","Diptera","genomic features","out-of-X movement."],"has_accepted_license":"1","file":[{"file_id":"20834","success":1,"checksum":"0b79be6229f2ad9ac117ef00fc4f5c0e","file_name":"README.txt","creator":"llayanaf","access_level":"open_access","date_created":"2025-12-17T10:09:25Z","content_type":"text/plain","file_size":1201,"date_updated":"2025-12-17T10:09:25Z","relation":"main_file"},{"file_id":"20835","success":1,"checksum":"daf1c03149dd170b14e5c8e109ee3c77","file_name":"Supplementary_Datasets.zip","date_created":"2025-12-17T10:10:11Z","access_level":"open_access","creator":"llayanaf","content_type":"application/zip","file_size":19052849,"relation":"main_file","date_updated":"2025-12-17T10:10:11Z"},{"file_id":"20837","success":1,"checksum":"251e7aab01917c2ad2fbccf465492ea1","file_name":"Perl_scripts.zip","date_created":"2025-12-17T10:12:05Z","access_level":"open_access","creator":"llayanaf","file_size":4575,"content_type":"application/zip","relation":"main_file","date_updated":"2025-12-17T10:12:05Z"},{"file_name":"Supplementary_Tables.zip","checksum":"3cabf143b8cd286eae48c598da2b03bd","success":1,"file_id":"20959","date_updated":"2026-01-08T01:35:08Z","relation":"main_file","content_type":"application/zip","file_size":572362,"creator":"llayanaf","access_level":"open_access","date_created":"2026-01-08T01:35:08Z"}],"citation":{"ieee":"L. A. Layana Franco, M. A. Toups, and B. Vicoso, “Research Data for ‘Causes and consequences of sex-chromosome turnovers in Diptera.’” Institute of Science and Technology Austria, 2026.","apa":"Layana Franco, L. A., Toups, M. A., &#38; Vicoso, B. (2026). Research Data for “Causes and consequences of sex-chromosome turnovers in Diptera.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20833\">https://doi.org/10.15479/AT-ISTA-20833</a>","ama":"Layana Franco LA, Toups MA, Vicoso B. Research Data for “Causes and consequences of sex-chromosome turnovers in Diptera.” 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20833\">10.15479/AT-ISTA-20833</a>","mla":"Layana Franco, Lorena Alexandra, et al. <i>Research Data for “Causes and Consequences of Sex-Chromosome Turnovers in Diptera.”</i> Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20833\">10.15479/AT-ISTA-20833</a>.","chicago":"Layana Franco, Lorena Alexandra, Melissa A Toups, and Beatriz Vicoso. “Research Data for ‘Causes and Consequences of Sex-Chromosome Turnovers in Diptera.’” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-20833\">https://doi.org/10.15479/AT-ISTA-20833</a>.","short":"L.A. Layana Franco, M.A. Toups, B. Vicoso, (2026).","ista":"Layana Franco LA, Toups MA, Vicoso B. 2026. Research Data for ‘Causes and consequences of sex-chromosome turnovers in Diptera’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-20833\">10.15479/AT-ISTA-20833</a>."},"doi":"10.15479/AT-ISTA-20833","corr_author":"1","author":[{"full_name":"Layana Franco, Lorena Alexandra","last_name":"Layana Franco","id":"02814589-eb8f-11eb-b029-a70074f3f18f","first_name":"Lorena Alexandra","orcid":"0000-0002-1253-6297"},{"id":"4E099E4E-F248-11E8-B48F-1D18A9856A87","last_name":"Toups","full_name":"Toups, Melissa A","first_name":"Melissa A","orcid":"0000-0002-9752-7380"},{"orcid":"0000-0002-4579-8306","first_name":"Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","last_name":"Vicoso","full_name":"Vicoso, Beatriz"}],"date_published":"2026-01-08T00:00:00Z","status":"public","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","department":[{"_id":"BeVi"}],"year":"2026"}]