---
res:
  bibo_abstract:
  - Insulin/insulin-like growth factor signaling inhibits FOXO transcription factors
    to control development, homeostasis, and aging. Here, we use proximity labeling
    to identify proteins interacting with the C. elegans FOXO DAF-16. We show that
    in well-fed, unstressed animals harboring active insulin signaling, DAF-16 forms
    a complex with the PAR-1/MARK serine/threonine kinase, a key regulator of cell
    polarity. PAR-1 inhibits DAF-16 accumulation and promotes DAF-16 phosphorylation
    at S249, at a conserved motif that PAR-1/human MARK2 phosphorylates in vitro.
    DAF-2 insulin-like receptor signaling stimulates DAF-16 S249 phosphorylation,
    suggesting DAF-2 activates PAR-1. DAF-2 also promotes PAR-1 expression by inhibiting
    DAF-16. PAR-1 knockdown, or DAF-16 S249A, prolong lifespan, whereas phosphomimetic
    DAF-16 S249D suppresses the longevity of daf-2 mutants. At low insulin signaling,
    DAF-16 proximity labeling highlights transcription factors, chromatin regulators,
    and DNA repair proteins. One interactor, the zinc finger/homeobox protein ZFH-2/ZFHX3,
    forms a complex with DAF-16 and prolongs lifespan. Our work provides entry points
    for hypothesis-driven studies of FOXO function and longevity.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Murat
      foaf_name: Artan, Murat
      foaf_surname: Artan
      foaf_workInfoHomepage: http://www.librecat.org/personId=C407B586-6052-11E9-B3AE-7006E6697425
    orcid: 0000-0001-8945-6992
  - foaf_Person:
      foaf_givenName: Hanna
      foaf_name: Schön, Hanna
      foaf_surname: Schön
      foaf_workInfoHomepage: http://www.librecat.org/personId=C8E17EDC-D7AA-11E9-B7B7-45ECE5697425
  - foaf_Person:
      foaf_givenName: Mario
      foaf_name: De Bono, Mario
      foaf_surname: De Bono
      foaf_workInfoHomepage: http://www.librecat.org/personId=4E3FF80E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8347-0443
  bibo_doi: 10.1038/s41467-025-66409-0
  bibo_volume: 16
  dct_date: 2025^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2041-1723
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Proximity labeling of DAF-16 FOXO highlights aging regulatory proteins@
  fabio_hasPubmedId: '41381452'
...