{"publication_status":"published","publication":"Angewandte Chemie International Edition","has_accepted_license":"1","intvolume":"        64","external_id":{"pmid":["40346004"]},"article_type":"original","article_processing_charge":"Yes (in subscription journal)","oa":1,"year":"2025","extern":"1","ddc":["540"],"quality_controlled":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1002/anie.202505273"}],"date_created":"2026-01-08T07:04:48Z","volume":64,"article_number":"e202505273","author":[{"full_name":"Loos, Manuel","last_name":"Loos","first_name":"Manuel"},{"last_name":"Xu","full_name":"Xu, Felix","first_name":"Felix"},{"full_name":"Mandal, Pradeep K","last_name":"Mandal","first_name":"Pradeep K","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","orcid":"0000-0001-5996-956X"},{"last_name":"Chakrabortty","full_name":"Chakrabortty, Tulika","first_name":"Tulika"},{"first_name":"Céline","last_name":"Douat","full_name":"Douat, Céline"},{"full_name":"Konrad, David B.","last_name":"Konrad","first_name":"David B."},{"full_name":"Cabbar, Melis","last_name":"Cabbar","first_name":"Melis"},{"first_name":"Johannes","last_name":"Singer","full_name":"Singer, Johannes"},{"last_name":"Corvaglia","full_name":"Corvaglia, Valentina","first_name":"Valentina"},{"full_name":"Carell, Thomas","last_name":"Carell","first_name":"Thomas"},{"first_name":"Ivan","last_name":"Huc","full_name":"Huc, Ivan"}],"publication_identifier":{"issn":["1433-7851"],"eissn":["1521-3773"]},"OA_place":"publisher","date_published":"2025-07-28T00:00:00Z","abstract":[{"text":"A linker unit was designed and synthesized that can serve both as a hairpin turn in a DNA duplex and anchor point for an aromatic helical foldamer mimicking the shape and surface properties of B‐DNA. Methods were developed to synthesize natural/non‐natural chimeric molecules combining foldamer and DNA segments. The ability of the linker to position the foldamer helix and the duplex DNA so that their rims and grooves are in register, despite their completely different chemical nature, was demonstrated using single crystal X‐ray diffraction, circular dichroism and molecular models. Bio‐layer interferometry confirmed that artificial hairpin DNA duplexes keep their ability to bind to DNA binding proteins. The chimeric molecules may pave the way to competitive inhibitors of protein‐DNA interactions involving sequence‐selective DNA‐binding proteins.","lang":"eng"}],"date_updated":"2026-01-19T11:07:53Z","_id":"20960","doi":"10.1002/anie.202505273","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"scopus_import":"1","pmid":1,"issue":"31","month":"07","PlanS_conform":"1","oa_version":"Published Version","title":"Interfacing B‐DNA and DNA mimic foldamers","language":[{"iso":"eng"}],"type":"journal_article","OA_type":"hybrid","citation":{"ama":"Loos M, Xu F, Mandal PK, et al. Interfacing B‐DNA and DNA mimic foldamers. <i>Angewandte Chemie International Edition</i>. 2025;64(31). doi:<a href=\"https://doi.org/10.1002/anie.202505273\">10.1002/anie.202505273</a>","ista":"Loos M, Xu F, Mandal PK, Chakrabortty T, Douat C, Konrad DB, Cabbar M, Singer J, Corvaglia V, Carell T, Huc I. 2025. Interfacing B‐DNA and DNA mimic foldamers. Angewandte Chemie International Edition. 64(31), e202505273.","ieee":"M. Loos <i>et al.</i>, “Interfacing B‐DNA and DNA mimic foldamers,” <i>Angewandte Chemie International Edition</i>, vol. 64, no. 31. Wiley, 2025.","short":"M. Loos, F. Xu, P.K. Mandal, T. Chakrabortty, C. Douat, D.B. Konrad, M. Cabbar, J. Singer, V. Corvaglia, T. Carell, I. Huc, Angewandte Chemie International Edition 64 (2025).","mla":"Loos, Manuel, et al. “Interfacing B‐DNA and DNA Mimic Foldamers.” <i>Angewandte Chemie International Edition</i>, vol. 64, no. 31, e202505273, Wiley, 2025, doi:<a href=\"https://doi.org/10.1002/anie.202505273\">10.1002/anie.202505273</a>.","chicago":"Loos, Manuel, Felix Xu, Pradeep K Mandal, Tulika Chakrabortty, Céline Douat, David B. Konrad, Melis Cabbar, et al. “Interfacing B‐DNA and DNA Mimic Foldamers.” <i>Angewandte Chemie International Edition</i>. Wiley, 2025. <a href=\"https://doi.org/10.1002/anie.202505273\">https://doi.org/10.1002/anie.202505273</a>.","apa":"Loos, M., Xu, F., Mandal, P. K., Chakrabortty, T., Douat, C., Konrad, D. B., … Huc, I. (2025). Interfacing B‐DNA and DNA mimic foldamers. <i>Angewandte Chemie International Edition</i>. Wiley. <a href=\"https://doi.org/10.1002/anie.202505273\">https://doi.org/10.1002/anie.202505273</a>"},"day":"28","publisher":"Wiley","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"}