{"article_processing_charge":"Yes (in subscription journal)","date_updated":"2026-01-20T06:56:44Z","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1039/D4OB01436G"}],"day":"30","license":"https://creativecommons.org/licenses/by/3.0/","citation":{"mla":"Kwon, Sunbum, et al. “Interrogating the Potential of Helical Aromatic Foldamers for Protein Recognition.” <i>Organic &#38; Biomolecular Chemistry</i>, vol. 22, no. 48, Royal Society of Chemistry, 2024, pp. 9342–47, doi:<a href=\"https://doi.org/10.1039/d4ob01436g\">10.1039/d4ob01436g</a>.","apa":"Kwon, S., Morozov, V., Wang, L., Mandal, P. K., Chaignepain, S., Douat, C., &#38; Huc, I. (2024). Interrogating the potential of helical aromatic foldamers for protein recognition. <i>Organic &#38; Biomolecular Chemistry</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d4ob01436g\">https://doi.org/10.1039/d4ob01436g</a>","ista":"Kwon S, Morozov V, Wang L, Mandal PK, Chaignepain S, Douat C, Huc I. 2024. Interrogating the potential of helical aromatic foldamers for protein recognition. Organic &#38; Biomolecular Chemistry. 22(48), 9342–9347.","chicago":"Kwon, Sunbum, Vasily Morozov, Lingfei Wang, Pradeep K Mandal, Stéphane Chaignepain, Céline Douat, and Ivan Huc. “Interrogating the Potential of Helical Aromatic Foldamers for Protein Recognition.” <i>Organic &#38; Biomolecular Chemistry</i>. Royal Society of Chemistry, 2024. <a href=\"https://doi.org/10.1039/d4ob01436g\">https://doi.org/10.1039/d4ob01436g</a>.","ieee":"S. Kwon <i>et al.</i>, “Interrogating the potential of helical aromatic foldamers for protein recognition,” <i>Organic &#38; Biomolecular Chemistry</i>, vol. 22, no. 48. Royal Society of Chemistry, pp. 9342–9347, 2024.","ama":"Kwon S, Morozov V, Wang L, et al. Interrogating the potential of helical aromatic foldamers for protein recognition. <i>Organic &#38; Biomolecular Chemistry</i>. 2024;22(48):9342-9347. doi:<a href=\"https://doi.org/10.1039/d4ob01436g\">10.1039/d4ob01436g</a>","short":"S. Kwon, V. Morozov, L. Wang, P.K. Mandal, S. Chaignepain, C. Douat, I. Huc, Organic &#38; Biomolecular Chemistry 22 (2024) 9342–9347."},"title":"Interrogating the potential of helical aromatic foldamers for protein recognition","publisher":"Royal Society of Chemistry","date_created":"2026-01-11T14:32:23Z","article_type":"original","abstract":[{"lang":"eng","text":"A biotinylated helical aromatic oligoamide foldamer equivalent in size to a 24mer peptide was designed without any prejudice other than to display various polar and hydrophobic side chains at its surface. It was synthesized on solid phase, its P- and M-helical conformers were separated by HPLC on a chiral stationary phase, and the solid state structure of a non-biotinylated analogue was elucidated by X-ray crystallography. Pull-down experiments from a yeast cell lysate using the foldamer as a bait followed by proteomic analysis revealed potential protein binding partners. Three of these proteins were recombinantly expressed. Biolayer interferometry showed submicromolar binding demonstrating the potential of a given foldamer to have affinity for certain proteins in the absence of design considerations. Yet, binding selectivity was low in all three cases since both P- and M-conformers bound to the proteins with similar affinities."}],"oa":1,"doi":"10.1039/d4ob01436g","pmid":1,"PlanS_conform":"1","extern":"1","publication_status":"published","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/3.0/legalcode","name":"Creative Commons Attribution 3.0 Unported (CC BY 3.0)","image":"/images/cc_by.png","short":"CC BY (3.0)"},"year":"2024","has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["1477-0539"],"issn":["1477-0520"]},"status":"public","oa_version":"Published Version","_id":"20967","page":"9342-9347","author":[{"full_name":"Kwon, Sunbum","first_name":"Sunbum","last_name":"Kwon"},{"full_name":"Morozov, Vasily","last_name":"Morozov","first_name":"Vasily"},{"last_name":"Wang","first_name":"Lingfei","full_name":"Wang, Lingfei"},{"last_name":"Mandal","orcid":"0000-0001-5996-956X","first_name":"Pradeep K","full_name":"Mandal, Pradeep K","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3"},{"full_name":"Chaignepain, Stéphane","last_name":"Chaignepain","first_name":"Stéphane"},{"first_name":"Céline","last_name":"Douat","full_name":"Douat, Céline"},{"first_name":"Ivan","last_name":"Huc","full_name":"Huc, Ivan"}],"date_published":"2024-10-30T00:00:00Z","OA_type":"hybrid","language":[{"iso":"eng"}],"issue":"48","month":"10","external_id":{"pmid":["39501876"]},"OA_place":"publisher","publication":"Organic & Biomolecular Chemistry","intvolume":"        22","type":"journal_article","scopus_import":"1","quality_controlled":"1","volume":22}