Self-assembly of achiral building blocks into chiral cyclophanes using non-directional interactions Zhang, Yuan Ourri, Benjamin Skowron, Pierre-Thomas Jeamet, Emeric Chetot, Titouan Duchamp, Christian Belenguer, Ana M. Vanthuyne, Nicolas Cala, Olivier Dumont, Elise Mandal, Pradeep K ; https://orcid.org/0000-0001-5996-956X Huc, Ivan Perret, Florent Vial, Laurent Leclaire, Julien ddc:540 The diastereoselective assembly of achiral constituents through a single spontaneous process into complex covalent architectures bearing multiple stereogenic elements still remains a challenge for synthetic chemists. Here, we show that such an extreme level of control can be achieved by implementing stereo-electronic information on synthetic organic building blocks and templates and that non-directional interactions (i.e., electrostatic and steric interactions) can transfer this information to deliver, after self-assembly, high-molecular weight macrocyclic species carrying up to 16 stereogenic elements. Beyond the field of supramolecular chemistry, this proof of concept should stimulate the on-demand production of highly structured polyfunctional architectures. Royal Society of Chemistry 2023 info:eu-repo/semantics/article doc-type:article text http://purl.org/coar/resource_type/c_2df8fbb1 https://research-explorer.ista.ac.at/record/20969 Zhang Y, Ourri B, Skowron P-T, et al. Self-assembly of achiral building blocks into chiral cyclophanes using non-directional interactions. <i>Chemical Science</i>. 2023;14(26):7126-7135. doi:<a href="https://doi.org/10.1039/d3sc01235b">10.1039/d3sc01235b</a> eng info:eu-repo/semantics/altIdentifier/doi/10.1039/d3sc01235b info:eu-repo/semantics/altIdentifier/issn/2041-6520 info:eu-repo/semantics/altIdentifier/e-issn/2041-6539 info:eu-repo/semantics/altIdentifier/pmid/37416699 https://creativecommons.org/licenses/by-nc/3.0/ info:eu-repo/semantics/openAccess