article published yes Yuan Zhang author Benjamin Ourri author Pierre-Thomas Skowron author Emeric Jeamet author Titouan Chetot author Christian Duchamp author Ana M. Belenguer author Nicolas Vanthuyne author Olivier Cala author Elise Dumont author Pradeep K Mandal author 6a3def15-d4b4-11ef-9fa9-a24c1f545ec30000-0001-5996-956X Ivan Huc author Florent Perret author Laurent Vial author Julien Leclaire author The diastereoselective assembly of achiral constituents through a single spontaneous process into complex covalent architectures bearing multiple stereogenic elements still remains a challenge for synthetic chemists. Here, we show that such an extreme level of control can be achieved by implementing stereo-electronic information on synthetic organic building blocks and templates and that non-directional interactions (i.e., electrostatic and steric interactions) can transfer this information to deliver, after self-assembly, high-molecular weight macrocyclic species carrying up to 16 stereogenic elements. Beyond the field of supramolecular chemistry, this proof of concept should stimulate the on-demand production of highly structured polyfunctional architectures. Royal Society of Chemistry2023 eng 2041-6520 2041-6539 3741669910.1039/d3sc01235b 14267126-7135 yes Y. Zhang <i>et al.</i>, “Self-assembly of achiral building blocks into chiral cyclophanes using non-directional interactions,” <i>Chemical Science</i>, vol. 14, no. 26. Royal Society of Chemistry, pp. 7126–7135, 2023. Zhang, Y., Ourri, B., Skowron, P.-T., Jeamet, E., Chetot, T., Duchamp, C., … Leclaire, J. (2023). Self-assembly of achiral building blocks into chiral cyclophanes using non-directional interactions. <i>Chemical Science</i>. Royal Society of Chemistry. <a href="https://doi.org/10.1039/d3sc01235b">https://doi.org/10.1039/d3sc01235b</a> Zhang, Yuan, et al. “Self-Assembly of Achiral Building Blocks into Chiral Cyclophanes Using Non-Directional Interactions.” <i>Chemical Science</i>, vol. 14, no. 26, Royal Society of Chemistry, 2023, pp. 7126–35, doi:<a href="https://doi.org/10.1039/d3sc01235b">10.1039/d3sc01235b</a>. Zhang Y, Ourri B, Skowron P-T, et al. Self-assembly of achiral building blocks into chiral cyclophanes using non-directional interactions. <i>Chemical Science</i>. 2023;14(26):7126-7135. doi:<a href="https://doi.org/10.1039/d3sc01235b">10.1039/d3sc01235b</a> Zhang, Yuan, Benjamin Ourri, Pierre-Thomas Skowron, Emeric Jeamet, Titouan Chetot, Christian Duchamp, Ana M. Belenguer, et al. “Self-Assembly of Achiral Building Blocks into Chiral Cyclophanes Using Non-Directional Interactions.” <i>Chemical Science</i>. Royal Society of Chemistry, 2023. <a href="https://doi.org/10.1039/d3sc01235b">https://doi.org/10.1039/d3sc01235b</a>. Zhang Y, Ourri B, Skowron P-T, Jeamet E, Chetot T, Duchamp C, Belenguer AM, Vanthuyne N, Cala O, Dumont E, Mandal PK, Huc I, Perret F, Vial L, Leclaire J. 2023. Self-assembly of achiral building blocks into chiral cyclophanes using non-directional interactions. Chemical Science. 14(26), 7126–7135. Y. Zhang, B. Ourri, P.-T. Skowron, E. Jeamet, T. Chetot, C. Duchamp, A.M. Belenguer, N. Vanthuyne, O. Cala, E. Dumont, P.K. Mandal, I. Huc, F. Perret, L. Vial, J. Leclaire, Chemical Science 14 (2023) 7126–7135. 209692026-01-11T14:38:38Z2026-01-20T07:04:16Z