---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '20969'
abstract:
- lang: eng
  text: The diastereoselective assembly of achiral constituents through a single spontaneous
    process into complex covalent architectures bearing multiple stereogenic elements
    still remains a challenge for synthetic chemists. Here, we show that such an extreme
    level of control can be achieved by implementing stereo-electronic information
    on synthetic organic building blocks and templates and that non-directional interactions
    (i.e., electrostatic and steric interactions) can transfer this information to
    deliver, after self-assembly, high-molecular weight macrocyclic species carrying
    up to 16 stereogenic elements. Beyond the field of supramolecular chemistry, this
    proof of concept should stimulate the on-demand production of highly structured
    polyfunctional architectures.
article_processing_charge: Yes
article_type: original
author:
- first_name: Yuan
  full_name: Zhang, Yuan
  last_name: Zhang
- first_name: Benjamin
  full_name: Ourri, Benjamin
  last_name: Ourri
- first_name: Pierre-Thomas
  full_name: Skowron, Pierre-Thomas
  last_name: Skowron
- first_name: Emeric
  full_name: Jeamet, Emeric
  last_name: Jeamet
- first_name: Titouan
  full_name: Chetot, Titouan
  last_name: Chetot
- first_name: Christian
  full_name: Duchamp, Christian
  last_name: Duchamp
- first_name: Ana M.
  full_name: Belenguer, Ana M.
  last_name: Belenguer
- first_name: Nicolas
  full_name: Vanthuyne, Nicolas
  last_name: Vanthuyne
- first_name: Olivier
  full_name: Cala, Olivier
  last_name: Cala
- first_name: Elise
  full_name: Dumont, Elise
  last_name: Dumont
- first_name: Pradeep K
  full_name: Mandal, Pradeep K
  id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
  last_name: Mandal
  orcid: 0000-0001-5996-956X
- first_name: Ivan
  full_name: Huc, Ivan
  last_name: Huc
- first_name: Florent
  full_name: Perret, Florent
  last_name: Perret
- first_name: Laurent
  full_name: Vial, Laurent
  last_name: Vial
- first_name: Julien
  full_name: Leclaire, Julien
  last_name: Leclaire
citation:
  ama: Zhang Y, Ourri B, Skowron P-T, et al. Self-assembly of achiral building blocks
    into chiral cyclophanes using non-directional interactions. <i>Chemical Science</i>.
    2023;14(26):7126-7135. doi:<a href="https://doi.org/10.1039/d3sc01235b">10.1039/d3sc01235b</a>
  apa: Zhang, Y., Ourri, B., Skowron, P.-T., Jeamet, E., Chetot, T., Duchamp, C.,
    … Leclaire, J. (2023). Self-assembly of achiral building blocks into chiral cyclophanes
    using non-directional interactions. <i>Chemical Science</i>. Royal Society of
    Chemistry. <a href="https://doi.org/10.1039/d3sc01235b">https://doi.org/10.1039/d3sc01235b</a>
  chicago: Zhang, Yuan, Benjamin Ourri, Pierre-Thomas Skowron, Emeric Jeamet, Titouan
    Chetot, Christian Duchamp, Ana M. Belenguer, et al. “Self-Assembly of Achiral
    Building Blocks into Chiral Cyclophanes Using Non-Directional Interactions.” <i>Chemical
    Science</i>. Royal Society of Chemistry, 2023. <a href="https://doi.org/10.1039/d3sc01235b">https://doi.org/10.1039/d3sc01235b</a>.
  ieee: Y. Zhang <i>et al.</i>, “Self-assembly of achiral building blocks into chiral
    cyclophanes using non-directional interactions,” <i>Chemical Science</i>, vol.
    14, no. 26. Royal Society of Chemistry, pp. 7126–7135, 2023.
  ista: Zhang Y, Ourri B, Skowron P-T, Jeamet E, Chetot T, Duchamp C, Belenguer AM,
    Vanthuyne N, Cala O, Dumont E, Mandal PK, Huc I, Perret F, Vial L, Leclaire J.
    2023. Self-assembly of achiral building blocks into chiral cyclophanes using non-directional
    interactions. Chemical Science. 14(26), 7126–7135.
  mla: Zhang, Yuan, et al. “Self-Assembly of Achiral Building Blocks into Chiral Cyclophanes
    Using Non-Directional Interactions.” <i>Chemical Science</i>, vol. 14, no. 26,
    Royal Society of Chemistry, 2023, pp. 7126–35, doi:<a href="https://doi.org/10.1039/d3sc01235b">10.1039/d3sc01235b</a>.
  short: Y. Zhang, B. Ourri, P.-T. Skowron, E. Jeamet, T. Chetot, C. Duchamp, A.M.
    Belenguer, N. Vanthuyne, O. Cala, E. Dumont, P.K. Mandal, I. Huc, F. Perret, L.
    Vial, J. Leclaire, Chemical Science 14 (2023) 7126–7135.
date_created: 2026-01-11T14:38:38Z
date_published: 2023-05-24T00:00:00Z
date_updated: 2026-01-20T07:04:16Z
day: '24'
ddc:
- '540'
doi: 10.1039/d3sc01235b
extern: '1'
external_id:
  pmid:
  - '37416699'
has_accepted_license: '1'
intvolume: '        14'
issue: '26'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/3.0/
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1039/D3SC01235B
month: '05'
oa: 1
oa_version: Published Version
page: 7126-7135
pmid: 1
publication: Chemical Science
publication_identifier:
  eissn:
  - 2041-6539
  issn:
  - 2041-6520
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: Self-assembly of achiral building blocks into chiral cyclophanes using non-directional
  interactions
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/3.0/legalcode
  name: Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)
  short: CC BY-NC (3.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2023'
...