---
res:
  bibo_abstract:
  - Dynamic foldamers are synthetic folded molecules which can change their conformation
    in response to an external stimulus and are currently at the forefront of foldamer
    chemistry. However, constitutionally dynamic foldamers, which can change not only
    their conformation but also their molecular constitution in response to their
    environment, are without precedent. We now report a size- and shape-switching
    small dynamic covalent foldamer network which responds to changes in pH. Specifically,
    acidic conditions direct the oligomerization of a dipeptide-based building block
    into a 16-subunit macrocycle with well-defined conformation and with high selectivity.
    At higher pH the same building block yields another cyclic foldamer with a smaller
    ring size (9mer). The two foldamers readily and repeatedly interconvert upon adjustment
    of the pH of the solution. We have previously shown that addition of a template
    can direct oligomerization of the same building block to yet other rings sizes
    (including a 12mer and a 13mer, accompanied by a minor amount of 14mer). This
    brings the total number of discrete foldamers that can be accessed from a single
    building block to five. For a single building block system to exhibit such highly
    diverse structure space is unique and sets this system of foldamers apart from
    proteins. Furthermore, the emergence of constitutional dynamicity opens up new
    avenues to foldamers with adaptive behavior.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Yulong
      foaf_name: Jin, Yulong
      foaf_surname: Jin
  - foaf_Person:
      foaf_givenName: Pradeep K
      foaf_name: Mandal, Pradeep K
      foaf_surname: Mandal
      foaf_workInfoHomepage: http://www.librecat.org/personId=6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
    orcid: 0000-0001-5996-956X
  - foaf_Person:
      foaf_givenName: Juntian
      foaf_name: Wu, Juntian
      foaf_surname: Wu
  - foaf_Person:
      foaf_givenName: Niklas
      foaf_name: Böcher, Niklas
      foaf_surname: Böcher
  - foaf_Person:
      foaf_givenName: Ivan
      foaf_name: Huc, Ivan
      foaf_surname: Huc
  - foaf_Person:
      foaf_givenName: Sijbren
      foaf_name: Otto, Sijbren
      foaf_surname: Otto
  bibo_doi: 10.1021/jacs.2c09325
  bibo_issue: '5'
  bibo_volume: 145
  dct_date: 2023^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0002-7863
  - http://id.crossref.org/issn/1520-5126
  dct_language: eng
  dct_publisher: American Chemical Society@
  dct_title: (Re-)directing oligomerization of a single building block into two specific
    dynamic covalent foldamers through pH@
  fabio_hasPubmedId: '36705469'
...