---
res:
  bibo_abstract:
  - Cellular plasticity, the ability of a differentiated cell to adopt another phenotypic
    identity, is restricted under basal conditions, but can be elicited upon damage.
    However, the molecular mechanism enabling such plasticity remains largely unexplored.
    Here, we report damage-induced cellular plasticity of secretory enteroendocrine
    cells (EEs) in the adult Drosophila midgut. Ionizing radiation induces EE fate
    conversion and activates stress-responsive programs in EE lineages, accompanied
    by the induction of the stress-inducible transcription factor Xrp1 and the cytokine
    gene upd3. Xrp1 and upd3 are both necessary for radiation-induced EE plasticity.
    Under basal conditions, EE-specific Xrp1 overexpression triggers ectopic expression
    of progenitor-specific genes, which is necessary for Xrp1 to drive EE plasticity.
    Our work identifies Xrp1 as a crucial regulator that coordinates damage-induced
    signaling and transcriptional reprogramming, enabling the reactivation of cellular
    plasticity in differentiated cells.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Qingyin
      foaf_name: Qian, Qingyin
      foaf_surname: Qian
  - foaf_Person:
      foaf_givenName: Hiroki
      foaf_name: Nagai, Hiroki
      foaf_surname: Nagai
      foaf_workInfoHomepage: http://www.librecat.org/personId=608df3e6-e2ab-11ed-8890-c9318cec7da4
    orcid: 0000-0003-1671-9434
  - foaf_Person:
      foaf_givenName: Yuya
      foaf_name: Sanaki, Yuya
      foaf_surname: Sanaki
  - foaf_Person:
      foaf_givenName: Makoto
      foaf_name: Hayashi, Makoto
      foaf_surname: Hayashi
  - foaf_Person:
      foaf_givenName: Kenichi
      foaf_name: Kimura, Kenichi
      foaf_surname: Kimura
  - foaf_Person:
      foaf_givenName: Yu Ichiro
      foaf_name: Nakajima, Yu Ichiro
      foaf_surname: Nakajima
  - foaf_Person:
      foaf_givenName: Ryusuke
      foaf_name: Niwa, Ryusuke
      foaf_surname: Niwa
  bibo_doi: 10.1242/dev.205225
  bibo_issue: '2'
  bibo_volume: 153
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0950-1991
  - http://id.crossref.org/issn/1477-9129
  dct_language: eng
  dct_publisher: The Company of Biologists@
  dct_title: Xrp1 drives damage-induced cellular plasticity of enteroendocrine cells
    in the adult Drosophila midgut@
  fabio_hasPubmedId: '41392708'
...