---
OA_place: repository
OA_type: green
_id: '21039'
abstract:
- lang: eng
  text: Cellular plasticity, the ability of a differentiated cell to adopt another
    phenotypic identity, is restricted under basal conditions, but can be elicited
    upon damage. However, the molecular mechanism enabling such plasticity remains
    largely unexplored. Here, we report damage-induced cellular plasticity of secretory
    enteroendocrine cells (EEs) in the adult Drosophila midgut. Ionizing radiation
    induces EE fate conversion and activates stress-responsive programs in EE lineages,
    accompanied by the induction of the stress-inducible transcription factor Xrp1
    and the cytokine gene upd3. Xrp1 and upd3 are both necessary for radiation-induced
    EE plasticity. Under basal conditions, EE-specific Xrp1 overexpression triggers
    ectopic expression of progenitor-specific genes, which is necessary for Xrp1 to
    drive EE plasticity. Our work identifies Xrp1 as a crucial regulator that coordinates
    damage-induced signaling and transcriptional reprogramming, enabling the reactivation
    of cellular plasticity in differentiated cells.
acknowledgement: We thank Pierre Léopold, Tatsushi Igaki, Erik Storkebaum, Tobias
  Reiff, Masayuki Miura, Xiaohang Yang, Mikio Furuse, Bloomington Drosophila Stock
  Center and Developmental Studies Hybridoma Bank for providing us with fly stocks
  and reagents. We are also grateful to Hiromi Yanagisawa, Satoru Kobayashi, Md Al
  Amin Sheikh and Yaxuan Cui for allowing us to use their equipment, and to Allison
  Bardin, Pierre Léopold and Tadashi Uemura for helpful discussions.
article_number: dev205225
article_processing_charge: No
article_type: original
author:
- first_name: Qingyin
  full_name: Qian, Qingyin
  last_name: Qian
- first_name: Hiroki
  full_name: Nagai, Hiroki
  id: 608df3e6-e2ab-11ed-8890-c9318cec7da4
  last_name: Nagai
  orcid: 0000-0003-1671-9434
- first_name: Yuya
  full_name: Sanaki, Yuya
  last_name: Sanaki
- first_name: Makoto
  full_name: Hayashi, Makoto
  last_name: Hayashi
- first_name: Kenichi
  full_name: Kimura, Kenichi
  last_name: Kimura
- first_name: Yu Ichiro
  full_name: Nakajima, Yu Ichiro
  last_name: Nakajima
- first_name: Ryusuke
  full_name: Niwa, Ryusuke
  last_name: Niwa
citation:
  ama: Qian Q, NAGAI H, Sanaki Y, et al. Xrp1 drives damage-induced cellular plasticity
    of enteroendocrine cells in the adult Drosophila midgut. <i>Development</i>. 2026;153(2).
    doi:<a href="https://doi.org/10.1242/dev.205225">10.1242/dev.205225</a>
  apa: Qian, Q., NAGAI, H., Sanaki, Y., Hayashi, M., Kimura, K., Nakajima, Y. I.,
    &#38; Niwa, R. (2026). Xrp1 drives damage-induced cellular plasticity of enteroendocrine
    cells in the adult Drosophila midgut. <i>Development</i>. The Company of Biologists.
    <a href="https://doi.org/10.1242/dev.205225">https://doi.org/10.1242/dev.205225</a>
  chicago: Qian, Qingyin, HIROKI NAGAI, Yuya Sanaki, Makoto Hayashi, Kenichi Kimura,
    Yu Ichiro Nakajima, and Ryusuke Niwa. “Xrp1 Drives Damage-Induced Cellular Plasticity
    of Enteroendocrine Cells in the Adult Drosophila Midgut.” <i>Development</i>.
    The Company of Biologists, 2026. <a href="https://doi.org/10.1242/dev.205225">https://doi.org/10.1242/dev.205225</a>.
  ieee: Q. Qian <i>et al.</i>, “Xrp1 drives damage-induced cellular plasticity of
    enteroendocrine cells in the adult Drosophila midgut,” <i>Development</i>, vol.
    153, no. 2. The Company of Biologists, 2026.
  ista: Qian Q, NAGAI H, Sanaki Y, Hayashi M, Kimura K, Nakajima YI, Niwa R. 2026.
    Xrp1 drives damage-induced cellular plasticity of enteroendocrine cells in the
    adult Drosophila midgut. Development. 153(2), dev205225.
  mla: Qian, Qingyin, et al. “Xrp1 Drives Damage-Induced Cellular Plasticity of Enteroendocrine
    Cells in the Adult Drosophila Midgut.” <i>Development</i>, vol. 153, no. 2, dev205225,
    The Company of Biologists, 2026, doi:<a href="https://doi.org/10.1242/dev.205225">10.1242/dev.205225</a>.
  short: Q. Qian, H. NAGAI, Y. Sanaki, M. Hayashi, K. Kimura, Y.I. Nakajima, R. Niwa,
    Development 153 (2026).
date_created: 2026-01-25T23:01:39Z
date_published: 2026-01-15T00:00:00Z
date_updated: 2026-02-12T12:41:18Z
day: '15'
department:
- _id: XiFe
doi: 10.1242/dev.205225
external_id:
  pmid:
  - '41392708'
intvolume: '       153'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/2025.07.05.662934
month: '01'
oa: 1
oa_version: Preprint
pmid: 1
publication: Development
publication_identifier:
  eissn:
  - 1477-9129
  issn:
  - 0950-1991
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
scopus_import: '1'
status: public
title: Xrp1 drives damage-induced cellular plasticity of enteroendocrine cells in
  the adult Drosophila midgut
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 153
year: '2026'
...