{"oa_version":"Published Version","month":"07","quality_controlled":"1","article_processing_charge":"Yes","author":[{"full_name":"Dengler, Sebastian","first_name":"Sebastian","last_name":"Dengler"},{"id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","last_name":"Mandal","first_name":"Pradeep K","orcid":"0000-0001-5996-956X","full_name":"Mandal, Pradeep K"},{"first_name":"Lars","full_name":"Allmendinger, Lars","last_name":"Allmendinger"},{"last_name":"Douat","full_name":"Douat, Céline","first_name":"Céline"},{"full_name":"Huc, Ivan","first_name":"Ivan","last_name":"Huc"}],"article_type":"original","date_published":"2021-07-27T00:00:00Z","extern":"1","title":"Conformational interplay in hybrid peptide–helical aromatic foldamer macrocycles","abstract":[{"text":"Macrocyclic peptides are an important class of bioactive substances. When inserting an aromatic foldamer segment in a macrocyclic peptide, the strong folding propensity of the former may influence the conformation and alter the properties of the latter. Such an insertion is relevant because some foldamer–peptide hybrids have recently been shown to be tolerated by the ribosome, prior to forming macrocycles, and can thus be produced using an in vitro translation system. We have investigated the interplay of peptide and foldamer conformations in such hybrid macrocycles. We show that foldamer helical folding always prevails and stands as a viable means to stretch, i.e. unfold, peptides in a solvent dependent manner. Conversely, the peptide systematically has a reciprocal influence and gives rise to strong foldamer helix handedness bias as well as foldamer helix stabilisation. The hybrid macrocycles also show resistance towards proteolytic degradation.","lang":"eng"}],"ddc":["540"],"citation":{"ista":"Dengler S, Mandal PK, Allmendinger L, Douat C, Huc I. 2021. Conformational interplay in hybrid peptide–helical aromatic foldamer macrocycles. Chemical Science. 12(33), 11004–11012.","chicago":"Dengler, Sebastian, Pradeep K Mandal, Lars Allmendinger, Céline Douat, and Ivan Huc. “Conformational Interplay in Hybrid Peptide–Helical Aromatic Foldamer Macrocycles.” <i>Chemical Science</i>. Royal Society of Chemistry, 2021. <a href=\"https://doi.org/10.1039/d1sc03640h\">https://doi.org/10.1039/d1sc03640h</a>.","short":"S. Dengler, P.K. Mandal, L. Allmendinger, C. Douat, I. Huc, Chemical Science 12 (2021) 11004–11012.","apa":"Dengler, S., Mandal, P. K., Allmendinger, L., Douat, C., &#38; Huc, I. (2021). Conformational interplay in hybrid peptide–helical aromatic foldamer macrocycles. <i>Chemical Science</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d1sc03640h\">https://doi.org/10.1039/d1sc03640h</a>","ieee":"S. Dengler, P. K. Mandal, L. Allmendinger, C. Douat, and I. Huc, “Conformational interplay in hybrid peptide–helical aromatic foldamer macrocycles,” <i>Chemical Science</i>, vol. 12, no. 33. Royal Society of Chemistry, pp. 11004–11012, 2021.","mla":"Dengler, Sebastian, et al. “Conformational Interplay in Hybrid Peptide–Helical Aromatic Foldamer Macrocycles.” <i>Chemical Science</i>, vol. 12, no. 33, Royal Society of Chemistry, 2021, pp. 11004–12, doi:<a href=\"https://doi.org/10.1039/d1sc03640h\">10.1039/d1sc03640h</a>.","ama":"Dengler S, Mandal PK, Allmendinger L, Douat C, Huc I. Conformational interplay in hybrid peptide–helical aromatic foldamer macrocycles. <i>Chemical Science</i>. 2021;12(33):11004-11012. doi:<a href=\"https://doi.org/10.1039/d1sc03640h\">10.1039/d1sc03640h</a>"},"publication_status":"published","OA_type":"gold","language":[{"iso":"eng"}],"doi":"10.1039/d1sc03640h","page":"11004-11012","tmp":{"name":"Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)","short":"CC BY-NC (3.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/3.0/legalcode"},"year":"2021","publication_identifier":{"eissn":["2041-6539"],"issn":["2041-6520"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Chemical Science","_id":"21081","date_created":"2026-01-29T15:15:12Z","publisher":"Royal Society of Chemistry","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1039/D1SC03640H"}],"issue":"33","date_updated":"2026-02-20T06:57:41Z","volume":12,"has_accepted_license":"1","status":"public","day":"27","OA_place":"publisher","oa":1,"intvolume":"        12","license":"https://creativecommons.org/licenses/by-nc/3.0/","type":"journal_article"}