{"intvolume":"        12","type":"journal_article","oa":1,"OA_place":"repository","day":"20","date_updated":"2026-02-23T11:46:11Z","has_accepted_license":"1","volume":12,"status":"public","issue":"12","publisher":"Springer Nature","main_file_link":[{"open_access":"1","url":"https://doi.org/10.26434/chemrxiv.10079186"}],"pmid":1,"_id":"21084","date_created":"2026-01-29T15:32:38Z","publication":"Nature Chemistry","language":[{"iso":"eng"}],"doi":"10.1038/s41557-020-00565-2","publication_identifier":{"eissn":["1755-4349"],"issn":["1755-4330"]},"year":"2020","page":"1180-1186","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","OA_type":"green","citation":{"mla":"Pappas, Charalampos G., et al. “Emergence of Low-Symmetry Foldamers from Single Monomers.” <i>Nature Chemistry</i>, vol. 12, no. 12, Springer Nature, 2020, pp. 1180–86, doi:<a href=\"https://doi.org/10.1038/s41557-020-00565-2\">10.1038/s41557-020-00565-2</a>.","ama":"Pappas CG, Mandal PK, Liu B, et al. Emergence of low-symmetry foldamers from single monomers. <i>Nature Chemistry</i>. 2020;12(12):1180-1186. doi:<a href=\"https://doi.org/10.1038/s41557-020-00565-2\">10.1038/s41557-020-00565-2</a>","ieee":"C. G. Pappas <i>et al.</i>, “Emergence of low-symmetry foldamers from single monomers,” <i>Nature Chemistry</i>, vol. 12, no. 12. Springer Nature, pp. 1180–1186, 2020.","short":"C.G. Pappas, P.K. Mandal, B. Liu, B. Kauffmann, X. Miao, D. Komáromy, W. Hoffmann, C. Manz, R. Chang, K. Liu, K. Pagel, I. Huc, S. Otto, Nature Chemistry 12 (2020) 1180–1186.","apa":"Pappas, C. G., Mandal, P. K., Liu, B., Kauffmann, B., Miao, X., Komáromy, D., … Otto, S. (2020). Emergence of low-symmetry foldamers from single monomers. <i>Nature Chemistry</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41557-020-00565-2\">https://doi.org/10.1038/s41557-020-00565-2</a>","chicago":"Pappas, Charalampos G., Pradeep K Mandal, Bin Liu, Brice Kauffmann, Xiaoming Miao, Dávid Komáromy, Waldemar Hoffmann, et al. “Emergence of Low-Symmetry Foldamers from Single Monomers.” <i>Nature Chemistry</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41557-020-00565-2\">https://doi.org/10.1038/s41557-020-00565-2</a>.","ista":"Pappas CG, Mandal PK, Liu B, Kauffmann B, Miao X, Komáromy D, Hoffmann W, Manz C, Chang R, Liu K, Pagel K, Huc I, Otto S. 2020. Emergence of low-symmetry foldamers from single monomers. Nature Chemistry. 12(12), 1180–1186."},"abstract":[{"text":"Self-assembly is a powerful method to obtain large discrete functional molecular architectures. When using a single building block, self-assembly generally yields symmetrical objects in which all the subunits relate similarly to their neighbours. Here we report the discovery of a family of self-constructing cyclic macromolecules with stable folded conformations of low symmetry, which include some with a prime number (13, 17 and 23) of units, despite being formed from a single component. The formation of these objects amounts to the production of polymers with a perfectly uniform length. Design rules for the spontaneous emergence of such macromolecules include endowing monomers with a strong potential for non-covalent interactions that remain frustrated in competing entropically favoured yet conformationally restrained smaller cycles. The process can also be templated by a guest molecule that itself has an asymmetrical structure, which paves the way to molecular imprinting techniques at the level of single polymer chains.","lang":"eng"}],"date_published":"2020-11-20T00:00:00Z","extern":"1","external_id":{"pmid":["33219361 "]},"title":"Emergence of low-symmetry foldamers from single monomers","author":[{"last_name":"Pappas","first_name":"Charalampos G.","full_name":"Pappas, Charalampos G."},{"last_name":"Mandal","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","first_name":"Pradeep K","full_name":"Mandal, Pradeep K","orcid":"0000-0001-5996-956X"},{"full_name":"Liu, Bin","first_name":"Bin","last_name":"Liu"},{"first_name":"Brice","full_name":"Kauffmann, Brice","last_name":"Kauffmann"},{"last_name":"Miao","full_name":"Miao, Xiaoming","first_name":"Xiaoming"},{"last_name":"Komáromy","first_name":"Dávid","full_name":"Komáromy, Dávid"},{"last_name":"Hoffmann","full_name":"Hoffmann, Waldemar","first_name":"Waldemar"},{"last_name":"Manz","full_name":"Manz, Christian","first_name":"Christian"},{"last_name":"Chang","full_name":"Chang, Rayoon","first_name":"Rayoon"},{"last_name":"Liu","full_name":"Liu, Kai","first_name":"Kai"},{"last_name":"Pagel","first_name":"Kevin","full_name":"Pagel, Kevin"},{"last_name":"Huc","full_name":"Huc, Ivan","first_name":"Ivan"},{"last_name":"Otto","first_name":"Sijbren","full_name":"Otto, Sijbren"}],"article_type":"original","oa_version":"Preprint","month":"11","quality_controlled":"1","article_processing_charge":"No"}