{"status":"public","volume":85,"has_accepted_license":"1","date_updated":"2026-02-20T06:51:31Z","scopus_import":"1","pmid":1,"publisher":"Wiley","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1002/cplu.202000416"}],"issue":"7","oa":1,"intvolume":"        85","license":"https://creativecommons.org/licenses/by-nc/4.0/","type":"journal_article","day":"06","OA_place":"publisher","abstract":[{"text":"Foldamers combining aliphatic and aromatic main-chain units often produce atypical structures that cannot easily be accessed from purely aromatic or aliphatic sequences. We report solid-state evidence that sequences comprising α-amino acids and quinoline-based monomers adopt conformations that combine the folding propensities of both components. Foldamers 2 and 3 having an XQQ repeat motif (X=α-amino acid, Q=quinoline) were synthesized. Crystals of 2 (X=Phe, Q with an anionic side chain) obtained from water revealed an aromatic helix where amide groups belonging to the α-amino acids created a hydrogen-bond array typical of peptidic helices. Crystals of 3 (X=Ser, Q with a lipophilic side chain) obtained from organic solvents revealed a helix-turn-helix structure in which α-amino acid side chains interfere with main-chain hydrogen bonding. High sequence-dependency of the conformation is typical of peptides but is shown here to include aromatic folding features.","lang":"eng"}],"citation":{"mla":"Hu, Xiaobo, et al. “Hybrid Sequences That Express Both Aromatic Amide and Α‐peptidic Folding Features.” <i>ChemPlusChem</i>, vol. 85, no. 7, Wiley, 2020, pp. 1580–86, doi:<a href=\"https://doi.org/10.1002/cplu.202000416\">10.1002/cplu.202000416</a>.","ieee":"X. Hu, P. K. Mandal, B. Kauffmann, and I. Huc, “Hybrid sequences that express both aromatic amide and α‐peptidic folding features,” <i>ChemPlusChem</i>, vol. 85, no. 7. Wiley, pp. 1580–1586, 2020.","ama":"Hu X, Mandal PK, Kauffmann B, Huc I. Hybrid sequences that express both aromatic amide and α‐peptidic folding features. <i>ChemPlusChem</i>. 2020;85(7):1580-1586. doi:<a href=\"https://doi.org/10.1002/cplu.202000416\">10.1002/cplu.202000416</a>","short":"X. Hu, P.K. Mandal, B. Kauffmann, I. Huc, ChemPlusChem 85 (2020) 1580–1586.","apa":"Hu, X., Mandal, P. K., Kauffmann, B., &#38; Huc, I. (2020). Hybrid sequences that express both aromatic amide and α‐peptidic folding features. <i>ChemPlusChem</i>. Wiley. <a href=\"https://doi.org/10.1002/cplu.202000416\">https://doi.org/10.1002/cplu.202000416</a>","chicago":"Hu, Xiaobo, Pradeep K Mandal, Brice Kauffmann, and Ivan Huc. “Hybrid Sequences That Express Both Aromatic Amide and Α‐peptidic Folding Features.” <i>ChemPlusChem</i>. Wiley, 2020. <a href=\"https://doi.org/10.1002/cplu.202000416\">https://doi.org/10.1002/cplu.202000416</a>.","ista":"Hu X, Mandal PK, Kauffmann B, Huc I. 2020. Hybrid sequences that express both aromatic amide and α‐peptidic folding features. ChemPlusChem. 85(7), 1580–1586."},"article_processing_charge":"No","oa_version":"Published Version","author":[{"first_name":"Xiaobo","full_name":"Hu, Xiaobo","last_name":"Hu"},{"first_name":"Pradeep K","orcid":"0000-0001-5996-956X","full_name":"Mandal, Pradeep K","last_name":"Mandal","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3"},{"full_name":"Kauffmann, Brice","first_name":"Brice","last_name":"Kauffmann"},{"last_name":"Huc","full_name":"Huc, Ivan","first_name":"Ivan"}],"month":"07","article_type":"original","quality_controlled":"1","external_id":{"pmid":["32729681"]},"title":"Hybrid sequences that express both aromatic amide and α‐peptidic folding features","date_published":"2020-07-06T00:00:00Z","extern":"1","publication":"ChemPlusChem","date_created":"2026-01-29T15:34:50Z","_id":"21085","OA_type":"hybrid","publication_status":"published","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"publication_identifier":{"eissn":["2192-6506"]},"year":"2020","page":"1580-1586","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1002/cplu.202000416","language":[{"iso":"eng"}]}