{"_id":"21111","issue":"1","citation":{"ista":"Dileep KV, Tintu I, Mandal PK, Karthe P, Haridas M, Sadasivan C. 2012. Binding to PLA2 may contribute to the anti‐inflammatory activity of catechol. Chemical Biology &#38; Drug Design. 79(1), 143–147.","ieee":"K. V. Dileep, I. Tintu, P. K. Mandal, P. Karthe, M. Haridas, and C. Sadasivan, “Binding to PLA2 may contribute to the anti‐inflammatory activity of catechol,” <i>Chemical Biology &#38; Drug Design</i>, vol. 79, no. 1. Wiley, pp. 143–147, 2012.","apa":"Dileep, K. V., Tintu, I., Mandal, P. K., Karthe, P., Haridas, M., &#38; Sadasivan, C. (2012). Binding to PLA2 may contribute to the anti‐inflammatory activity of catechol. <i>Chemical Biology &#38; Drug Design</i>. Wiley. <a href=\"https://doi.org/10.1111/j.1747-0285.2011.01258.x\">https://doi.org/10.1111/j.1747-0285.2011.01258.x</a>","short":"K.V. Dileep, I. Tintu, P.K. Mandal, P. Karthe, M. Haridas, C. Sadasivan, Chemical Biology &#38; Drug Design 79 (2012) 143–147.","chicago":"Dileep, Kalarickal V., Ignatius Tintu, Pradeep K Mandal, Ponnuraj Karthe, Madathilkovilakathu Haridas, and Chittalakkottu Sadasivan. “Binding to PLA2 May Contribute to the Anti‐inflammatory Activity of Catechol.” <i>Chemical Biology &#38; Drug Design</i>. Wiley, 2012. <a href=\"https://doi.org/10.1111/j.1747-0285.2011.01258.x\">https://doi.org/10.1111/j.1747-0285.2011.01258.x</a>.","ama":"Dileep KV, Tintu I, Mandal PK, Karthe P, Haridas M, Sadasivan C. Binding to PLA2 may contribute to the anti‐inflammatory activity of catechol. <i>Chemical Biology &#38; Drug Design</i>. 2012;79(1):143-147. doi:<a href=\"https://doi.org/10.1111/j.1747-0285.2011.01258.x\">10.1111/j.1747-0285.2011.01258.x</a>","mla":"Dileep, Kalarickal V., et al. “Binding to PLA2 May Contribute to the Anti‐inflammatory Activity of Catechol.” <i>Chemical Biology &#38; Drug Design</i>, vol. 79, no. 1, Wiley, 2012, pp. 143–47, doi:<a href=\"https://doi.org/10.1111/j.1747-0285.2011.01258.x\">10.1111/j.1747-0285.2011.01258.x</a>."},"page":"143-147","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1111/j.1747-0285.2011.01258.x"}],"quality_controlled":"1","date_published":"2012-01-01T00:00:00Z","status":"public","OA_place":"publisher","abstract":[{"text":"Inhibiting PLA2 activity should, in theory, be an effective approach to control the inflammation. Several naturally occurring polyphenolic compounds have been reported as inhibitors of PLA2. Among the naturally occurring polyphenols, catechol (1,2-dihydroxybenzene) possesses anti-inflammatory activity. Catechol can inhibit cyclooxygenase and lipo-oxygenase. By means of enzyme kinetic study, it was revealed that catechol can inhibit PLA2 also. Crystal structure showed that catechol binds to PLA2 at the opening of the active site cleft. This might stop the entry of substrate into the active site. Hence, catechol can be used as a lead compound for the development of novel anti-inflammatory drugs with PLA2 as the target.","lang":"eng"}],"OA_type":"free access","language":[{"iso":"eng"}],"month":"01","title":"Binding to PLA2 may contribute to the anti‐inflammatory activity of catechol","oa":1,"intvolume":"        79","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Kalarickal V.","last_name":"Dileep","full_name":"Dileep, Kalarickal V."},{"full_name":"Tintu, Ignatius","first_name":"Ignatius","last_name":"Tintu"},{"last_name":"Mandal","first_name":"Pradeep K","orcid":"0000-0001-5996-956X","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","full_name":"Mandal, Pradeep K"},{"full_name":"Karthe, Ponnuraj","last_name":"Karthe","first_name":"Ponnuraj"},{"first_name":"Madathilkovilakathu","last_name":"Haridas","full_name":"Haridas, Madathilkovilakathu"},{"full_name":"Sadasivan, Chittalakkottu","last_name":"Sadasivan","first_name":"Chittalakkottu"}],"day":"01","extern":"1","publication":"Chemical Biology & Drug Design","type":"journal_article","doi":"10.1111/j.1747-0285.2011.01258.x","article_processing_charge":"No","date_created":"2026-01-29T22:12:53Z","volume":79,"date_updated":"2026-02-20T08:20:52Z","publication_status":"published","article_type":"original","publication_identifier":{"issn":["1747-0277"],"eissn":["1747-0285"]},"external_id":{"pmid":["21995306"]},"pmid":1,"year":"2012","has_accepted_license":"1","publisher":"Wiley","oa_version":"Published Version"}