---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21158'
abstract:
- lang: eng
  text: Vernalization-regulated flowering is vital for wheat yield and geographical
    distribution, and the diversity of flowering time genes is essential for the breeding
    of climate-resilient varieties. Sugars have long been recognized in regulating
    flowering; however, the intrinsic connection between carbohydrate metabolism and
    vernalization response remains largely unexplored. Here, we identify a fructose
    1,6-bisphosphate aldolase (FBA) encoding gene, HtL1/FBA10, as a modulator of heading
    time variation based on a genome-wide association study utilizing wheat core germplasm
    collections. Evolutionary analysis shows a decrease in the proportion of haplotype-2
    of HtL1, which is linked to delayed flowering, in Chinese and American wheat varieties
    compared to landraces. Vernalization reduces HtL1/FBA10 phosphorylation levels
    and  increases  its O-GlcNAcylation, which in turn enhances its enzymatic activity
    and facilitates VERNALIZATION 1 (VRN1) transcription by regulating histone acetylation
    at the VRN1 locus. Our findings provide mechanistic insights into the interplay
    between glucose metabolism and the epigenetic regulation of vernalization in winter
    wheat.
acknowledgement: This work was supported by the Basic Science Center Project of National
  Natural Science Foundation of China (32388201) to K.C and the National Natural Science
  Foundation of China (31970331) to L.X. We thank Dr. Zhuang Lu, Dr. Bin Han and Ms.
  Jingquan Li (Plant Science Facility of the Institute of Botany, Chinese Academy
  of Sciences) for their technical assistance in LC-MS/MS assay, small molecule compound
  analysis and the subcellular localization assay, respectively. We thank Dr. Wei
  Luo and Dr. Dongfeng Liu for helpful discussions.
article_number: '999'
article_processing_charge: Yes
article_type: original
author:
- first_name: Pengfang
  full_name: Yang, Pengfang
  last_name: Yang
- first_name: Yangyang
  full_name: Liu, Yangyang
  last_name: Liu
- first_name: Qi
  full_name: Dong, Qi
  last_name: Dong
- first_name: Yuting
  full_name: Miao, Yuting
  last_name: Miao
- first_name: Jianlong
  full_name: Zhang, Jianlong
  last_name: Zhang
- first_name: Shujuan
  full_name: Xu, Shujuan
  id: 9724dd9d-f591-11ee-bd51-e97ed0652286
  last_name: Xu
- first_name: Hong
  full_name: Zhao, Hong
  last_name: Zhao
- first_name: Yuda
  full_name: Niu, Yuda
  last_name: Niu
- first_name: Xueyong
  full_name: Zhang, Xueyong
  last_name: Zhang
- first_name: Yunyuan
  full_name: Xu, Yunyuan
  last_name: Xu
- first_name: Zifeng
  full_name: Guo, Zifeng
  last_name: Guo
- first_name: Lijing
  full_name: Xing, Lijing
  last_name: Xing
- first_name: Kang
  full_name: Chong, Kang
  last_name: Chong
citation:
  ama: Yang P, Liu Y, Dong Q, et al. O-GlcNAc and phosphorylation modifications on
    HtL1/FBA10 regulate wheat vernalization for flowering. <i>Nature Communications</i>.
    2026;17. doi:<a href="https://doi.org/10.1038/s41467-025-67734-0">10.1038/s41467-025-67734-0</a>
  apa: Yang, P., Liu, Y., Dong, Q., Miao, Y., Zhang, J., Xu, S., … Chong, K. (2026).
    O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization
    for flowering. <i>Nature Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-025-67734-0">https://doi.org/10.1038/s41467-025-67734-0</a>
  chicago: Yang, Pengfang, Yangyang Liu, Qi Dong, Yuting Miao, Jianlong Zhang, Shujuan
    Xu, Hong Zhao, et al. “O-GlcNAc and Phosphorylation Modifications on HtL1/FBA10
    Regulate Wheat Vernalization for Flowering.” <i>Nature Communications</i>. Springer
    Nature, 2026. <a href="https://doi.org/10.1038/s41467-025-67734-0">https://doi.org/10.1038/s41467-025-67734-0</a>.
  ieee: P. Yang <i>et al.</i>, “O-GlcNAc and phosphorylation modifications on HtL1/FBA10
    regulate wheat vernalization for flowering,” <i>Nature Communications</i>, vol.
    17. Springer Nature, 2026.
  ista: Yang P, Liu Y, Dong Q, Miao Y, Zhang J, Xu S, Zhao H, Niu Y, Zhang X, Xu Y,
    Guo Z, Xing L, Chong K. 2026. O-GlcNAc and phosphorylation modifications on HtL1/FBA10
    regulate wheat vernalization for flowering. Nature Communications. 17, 999.
  mla: Yang, Pengfang, et al. “O-GlcNAc and Phosphorylation Modifications on HtL1/FBA10
    Regulate Wheat Vernalization for Flowering.” <i>Nature Communications</i>, vol.
    17, 999, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41467-025-67734-0">10.1038/s41467-025-67734-0</a>.
  short: P. Yang, Y. Liu, Q. Dong, Y. Miao, J. Zhang, S. Xu, H. Zhao, Y. Niu, X. Zhang,
    Y. Xu, Z. Guo, L. Xing, K. Chong, Nature Communications 17 (2026).
date_created: 2026-02-08T23:02:48Z
date_published: 2026-01-27T00:00:00Z
date_updated: 2026-02-12T14:34:24Z
day: '27'
ddc:
- '580'
department:
- _id: XiFe
doi: 10.1038/s41467-025-67734-0
external_id:
  pmid:
  - '41455723'
file:
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  creator: dernst
  date_created: 2026-02-12T14:33:14Z
  date_updated: 2026-02-12T14:33:14Z
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  file_name: 2026_NatureComm_Yang.pdf
  file_size: 4685882
  relation: main_file
  success: 1
file_date_updated: 2026-02-12T14:33:14Z
has_accepted_license: '1'
intvolume: '        17'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization
  for flowering
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...