---
res:
  bibo_abstract:
  - In many species, sex-biased expression is widespread and thought to contribute
    to sexual dimorphism. While bulk RNA-sequencing has been instrumental in identifying
    strongly sex-biased genes, it lacks resolution to assess variation across cell-types
    and tissue compartments. Using single-nucleus expression data from the Fly Cell
    Atlas, we investigate sex differences in adult Drosophila melanogaster. We find
    that differences in cell-type composition between the sexes are not a major source
    of sex-bias, as for the vast majority of genes, the degree of sex-bias is similar
    regardless of whether sex differences in cell-type composition are controlled
    for or not. Our analysis confirms a deficit of X-linked male-biased genes in the
    body’s somatic tissues that is widespread across cell-types. We also find the
    excess of X-linked female-biased genes to be associated with nervous system cells
    in the head but with epithelial cells in the body’s somatic tissues, showing that
    single-nucleus data crucially resolves sex-bias at the cell-type level. We investigate
    dosage compensation (DC) across 15 tissues and 17 cell-types. We observe that
    it varies throughout the body. Surprisingly, we observe a lack of DC in a cluster
    of main cells within the male accessory glands. This result highlights the importance
    of understanding context-dependent DC.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Carolina
      foaf_name: De Castro Barbosa Rodrigues Barata, Carolina
      foaf_surname: De Castro Barbosa Rodrigues Barata
      foaf_workInfoHomepage: http://www.librecat.org/personId=20565186-803f-11ed-ab7e-96a4ff7694ef
    orcid: 0000-0003-1945-2245
  - foaf_Person:
      foaf_givenName: Beatriz
      foaf_name: Vicoso, Beatriz
      foaf_surname: Vicoso
      foaf_workInfoHomepage: http://www.librecat.org/personId=49E1C5C6-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-4579-8306
  bibo_doi: 10.1098/rspb.2025.2471
  bibo_issue: '2063'
  bibo_volume: 293
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1471-2954
  dct_language: eng
  dct_publisher: Royal Society of London@
  dct_title: Single-nucleus resolution of sex-biased expression and dosage compensation
    in Drosophila melanogaster@
  fabio_hasPubmedId: '41592777'
...