---
res:
  bibo_abstract:
  - Collagen IV is one of the main components of the basement membrane, a layer of
    material that lines the majority of tissues in multicellular organisms. Collagen
    IV molecules assemble into networks, providing stiffness and elasticity to tissues
    and informing cell and organ shape, especially during development. In this work,
    we develop two coarse-grained models for collagen IV molecules that retain biochemical
    bond specificity and coarse grain at different length scales. Through molecular-dynamics
    simulations, we test the assembly and mechanics of the resulting networks and
    measure their response to strain in terms of stress, microscopic alignment, and
    bond dynamics. Within the basement membrane, collagen IV networks rearrange by
    molecule turnover, which affects tissue organization and can be linked with enzyme
    activity. Here we explore network rearrangements via bond remodeling, the process
    of breaking and remaking of bonds between network molecules. We then investigate
    the effects of active (enzymatic) bond remodeling. We find that this nonequilibrium
    remodeling allows a network to keep its integrity under strain, while relaxing
    fully over a variety of timescales, a dynamic response that is unavailable to
    networks undergoing equilibrium remodeling.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Billie
      foaf_name: Meadowcroft, Billie
      foaf_surname: Meadowcroft
      foaf_workInfoHomepage: http://www.librecat.org/personId=a4725fd6-932b-11ed-81e2-c098c7f37ae1
    orcid: 0000-0003-3441-1337
  - foaf_Person:
      foaf_givenName: Valerio
      foaf_name: Sorichetti, Valerio
      foaf_surname: Sorichetti
      foaf_workInfoHomepage: http://www.librecat.org/personId=ef8a92cb-c7b6-11ec-8bea-e1fd5847bc5b
    orcid: 0000-0002-9645-6576
  - foaf_Person:
      foaf_givenName: Eryk
      foaf_name: Ratajczyk, Eryk
      foaf_surname: Ratajczyk
  - foaf_Person:
      foaf_givenName: Fernanda L
      foaf_name: Perez Verdugo, Fernanda L
      foaf_surname: Perez Verdugo
      foaf_workInfoHomepage: http://www.librecat.org/personId=4ecec223-9070-11ef-a0a9-bc76077bea8d
  - foaf_Person:
      foaf_givenName: Nargess
      foaf_name: Khalilgharibi, Nargess
      foaf_surname: Khalilgharibi
  - foaf_Person:
      foaf_givenName: Yanlan
      foaf_name: Mao, Yanlan
      foaf_surname: Mao
  - foaf_Person:
      foaf_givenName: Ivan
      foaf_name: Palaia, Ivan
      foaf_surname: Palaia
      foaf_workInfoHomepage: http://www.librecat.org/personId=9c805cd2-4b75-11ec-a374-db6dd0ed57fa
    orcid: ' 0000-0002-8843-9485 '
  - foaf_Person:
      foaf_givenName: Anđela
      foaf_name: Šarić, Anđela
      foaf_surname: Šarić
      foaf_workInfoHomepage: http://www.librecat.org/personId=bf63d406-f056-11eb-b41d-f263a6566d8b
    orcid: 0000-0002-7854-2139
  bibo_doi: 10.1103/gdd5-rnh7
  bibo_volume: 3
  dct_date: 2025^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2835-8279
  dct_language: eng
  dct_publisher: American Physical Society@
  dct_title: Nonequilibrium remodeling of collagen IV networks in Silico@
...