[{"year":"2026","oa":1,"tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"date_created":"2026-02-17T10:17:14Z","file_date_updated":"2026-02-17T10:11:14Z","month":"2","acknowledgement":"We thank Ben P. Tatman for insightful discussions. This research was supported by the Scientific Service Units (SSU) of Institute of Science and Technology Austria (ISTA) through resources provided by the Nuclear Magnetic Resonance Facility and the Lab Support Facility.","oa_version":"None","file":[{"file_name":"Research_data.zip","file_id":"21285","success":1,"checksum":"2d3105f26be578073b88ee1f2ea0bdb1","access_level":"open_access","relation":"main_file","content_type":"application/zip","date_updated":"2026-02-17T10:11:14Z","file_size":36996027,"date_created":"2026-02-17T10:11:14Z","creator":"lbecker"},{"content_type":"text/plain","checksum":"e24aebcdb8856cb181cbaa02de020ddb","access_level":"open_access","relation":"table_of_contents","file_id":"21286","file_name":"README.txt","date_created":"2026-02-17T10:11:14Z","creator":"lbecker","date_updated":"2026-02-17T10:11:14Z","file_size":1993}],"license":"https://creativecommons.org/licenses/by-nc/4.0/","OA_type":"free access","citation":{"ieee":"L. M. Becker and P. Schanda, “Research data for ‘Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants.’” Institute of Science and Technology Austria, 2026.","ama":"Becker LM, Schanda P. Research data for “Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants.” 2026. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21284\">10.15479/AT-ISTA-21284</a>","short":"L.M. Becker, P. Schanda, (2026).","chicago":"Becker, Lea Marie, and Paul Schanda. “Research Data for ‘Accelerated 19F Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.’” Institute of Science and Technology Austria, 2026. <a href=\"https://doi.org/10.15479/AT-ISTA-21284\">https://doi.org/10.15479/AT-ISTA-21284</a>.","ista":"Becker LM, Schanda P. 2026. Research data for ‘Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT-ISTA-21284\">10.15479/AT-ISTA-21284</a>.","mla":"Becker, Lea Marie, and Paul Schanda. <i>Research Data for “Accelerated 19F Biomolecular Magic-Angle Spinning NMR with Paramagnetic Dopants.”</i> Institute of Science and Technology Austria, 2026, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-21284\">10.15479/AT-ISTA-21284</a>.","apa":"Becker, L. M., &#38; Schanda, P. (2026). Research data for “Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-21284\">https://doi.org/10.15479/AT-ISTA-21284</a>"},"abstract":[{"text":"The advantageous characteristics attributed to the 19F nucleus have made it a popular target for NMR once again in recent years. Aside from solution NMR, an increasing number of studies have been conducted applying solid-state magic-angle-spinning NMR to fluorine-labeled samples. Here, the high chemical shift anisotropy and strong dipolar couplings can be utilized to get structural insights into proteins and measure long distances. Despite increasing popularity and promising benefits, the sensitivity of biomolecular 19F MAS NMR often suffers from slow longitudinal T1 relaxation and therefore long recycle delays. In this work, we expand paramagnetic doping, an approach commonly used to reduce proton T1 relaxation times, to 19F-labeled biological samples. We study the effect of Gd(DTPA) and Gd(DTPA-BMA) on 19F and 13C T1 and T2 relaxation in a [5-19F13C]-tryptophan-labeled protein via 19F-detected MAS NMR experiments. The observed paramagnetic relaxation enhancement substantially reduces measurement times of 19F MAS NMR experiments without compromising resolution. Additionally, we report the chemical-shift assignments of all four fluorotryptophan signals in the 12 × 39 kDa large protein using a mutagenesis approach.","lang":"eng"}],"contributor":[{"contributor_type":"researcher","last_name":"Toscano","first_name":"Giorgia","id":"334a5e40-8747-11f0-b671-ba1f5154b4b4"},{"first_name":"Anna","id":"9fb2a840-89e1-11ee-a8b7-cc5c7ba62471","last_name":"Kapitonova","contributor_type":"researcher"},{"id":"a3089acd-6806-11ee-bacc-f0c7d500ad20","first_name":"Rajkumar","last_name":"Singh","contributor_type":"researcher"},{"last_name":"Guillerm","contributor_type":"researcher","first_name":"Undina","id":"bb74f472-ae54-11eb-9835-bc9c22fb1183"},{"first_name":"Roman","contributor_type":"researcher","last_name":"Lichtenecker"}],"date_published":"2026-02-18T00:00:00Z","department":[{"_id":"GradSch"},{"_id":"PaSc"}],"OA_place":"repository","acknowledged_ssus":[{"_id":"NMR"},{"_id":"LifeSc"}],"author":[{"orcid":"0000-0002-6401-5151","last_name":"Becker","id":"36336939-eb97-11eb-a6c2-c83f1214ca79","first_name":"Lea Marie","full_name":"Becker, Lea Marie"},{"id":"7B541462-FAF6-11E9-A490-E8DFE5697425","first_name":"Paul","full_name":"Schanda, Paul","orcid":"0000-0002-9350-7606","last_name":"Schanda"}],"_id":"21284","doi":"10.15479/AT-ISTA-21284","status":"public","day":"18","type":"research_data","has_accepted_license":"1","date_updated":"2026-02-18T10:12:49Z","ddc":["541"],"article_processing_charge":"No","user_id":"68b8ca59-c5b3-11ee-8790-cd641c68093d","publisher":"Institute of Science and Technology Austria","corr_author":"1","title":"Research data for \"Accelerated 19F biomolecular magic-angle spinning NMR with paramagnetic dopants\""}]