---
res:
  bibo_abstract:
  - Auxin canalization is a self-organizing process that governs the flexible formation
    of vasculature by reinforcing the formation of auxin transport channels. A key
    prerequisite is the feedback between auxin signaling and directional auxin transport,
    mediated by PIN transporters. Despite the developmental importance of canalization,
    the molecular components linking auxin perception to the regulation of PIN auxin
    transporters remain poorly understood. Here, we identify TOW, a novel and essential
    component of auxin canalization that links intracellular auxin signaling with
    cell surface auxin perception. TOW is regulated downstream of TIR1/AFB-Aux/IAA-WRKY23
    transcriptional auxin signaling. tow mutants exhibit defects in regeneration and
    de novo vasculature formation, along with impaired formation of polarized, PIN-expressing
    auxin channels. At the subcellular level, these mutants display disrupted auxin-induced
    PIN polarization and altered PIN endocytic trafficking dynamics. TOW localizes
    predominantly to the plasma membrane, where it interacts with receptor-like kinases
    involved in auxin canalization, including the TMK1 auxin co-receptor and the CAMEL-CANAR
    complex. TOW promotes PIN interaction with these kinases and stabilizes PINs at
    the cell surface. Together, our findings identify TOW as a molecular link between
    intracellular and cell surface auxin signaling mechanisms that converge on PIN
    trafficking and polarity, providing new insights into how auxin signaling regulates
    directional auxin transport for the self-organizing formation of vasculature during
    flexible plant development.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Mingyue
      foaf_name: Li, Mingyue
      foaf_surname: Li
      foaf_workInfoHomepage: http://www.librecat.org/personId=01f96916-0235-11eb-9379-a323192643b7
  - foaf_Person:
      foaf_givenName: Nikola
      foaf_name: Rydza, Nikola
      foaf_surname: Rydza
  - foaf_Person:
      foaf_givenName: Ewa
      foaf_name: Mazur, Ewa
      foaf_surname: Mazur
  - foaf_Person:
      foaf_givenName: Gergely
      foaf_name: Molnar, Gergely
      foaf_surname: Molnar
      foaf_workInfoHomepage: http://www.librecat.org/personId=34F1AF46-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Tomasz
      foaf_name: Nodzyński, Tomasz
      foaf_surname: Nodzyński
  - foaf_Person:
      foaf_givenName: Jiří
      foaf_name: Friml, Jiří
      foaf_surname: Friml
      foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8302-7596
  bibo_doi: 10.1016/j.cub.2026.02.023
  bibo_issue: '6'
  bibo_volume: 36
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0960-9822
  dct_language: eng
  dct_publisher: Elsevier@
  dct_title: Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters
    for auxin canalization@
  fabio_hasPubmedId: '41831441'
...