---
res:
  bibo_abstract:
  - The present investigation confirms that initially implemented procedure to produce
    poly(methylidene malonate 2.1.2) (PMM 2.1.2) nanoparticles (Lescure et al. Pharm
    Res 1994;11:1270–77) lead to products mostly containing plasticizing oligomers
    which strongly lowered glass-transition temperature (Tg), dramatically reduced
    nanoparticle consistency and rendered them too sensitive to solubilization when
    diluted in an aqueous medium. From MALDI-TOF spectroscopy analysis, performed
    on intact colloids, emerged some structural information about these oligomeric
    species which could result from an intramolecular cyclization mechanism occurring
    soon in the course of the polymerization process. Thus, with the objective of
    overcoming these drawbacks, this contribution deals with the variations of manufacturing
    specifications such as pH and magnetic stirring speed to try and modulate molecular
    weight (Mw) of nanoparticle constituents and reduce oligomer concentration. Although
    the analyses performed on these new nanoparticles were rather encouraging, the
    colloid formation yield became so low that it required the developement of other
    methodologies, excluding a previous emulsion step, and allowing a controlled production
    of PMM 2.1.2-made nanoparticles having better physico-chemical characteristics
    while keeping good pharmaceutical capabilities.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: P
      foaf_name: Breton, P
      foaf_surname: Breton
  - foaf_Person:
      foaf_givenName: X
      foaf_name: Guillon, X
      foaf_surname: Guillon
  - foaf_Person:
      foaf_givenName: D
      foaf_name: Roy, D
      foaf_surname: Roy
  - foaf_Person:
      foaf_givenName: F
      foaf_name: Lescure, F
      foaf_surname: Lescure
  - foaf_Person:
      foaf_givenName: G
      foaf_name: Riess, G
      foaf_surname: Riess
  - foaf_Person:
      foaf_givenName: N
      foaf_name: Bru, N
      foaf_surname: Bru
  - foaf_Person:
      foaf_givenName: Charles
      foaf_name: Roques-Carmes, Charles
      foaf_surname: Roques-Carmes
      foaf_workInfoHomepage: http://www.librecat.org/personId=e2e68fc9-6505-11ef-a541-eb4e72cc3e82
  bibo_doi: 10.1016/s0142-9612(97)00243-3
  bibo_issue: 1-3
  bibo_volume: 19
  dct_date: 1998^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0142-9612
  dct_language: eng
  dct_publisher: Elsevier@
  dct_subject:
  - Colloid physico-chemical analysis
  - Colloidal drug carriers
  - MALDI-TOF spectroscopy
  - Nanoparticles
  - Poly(methylidene malonate)
  - Scanning electron microscopy
  dct_title: Physico-chemical characterization, preparation and performance of poly
    (methylidene malonate 2.1.2) nanoparticles@
  fabio_hasPubmedId: ' 9678876'
...