---
OA_type: closed access
_id: '21518'
abstract:
- lang: eng
  text: The present investigation confirms that initially implemented procedure to
    produce poly(methylidene malonate 2.1.2) (PMM 2.1.2) nanoparticles (Lescure et
    al. Pharm Res 1994;11:1270–77) lead to products mostly containing plasticizing
    oligomers which strongly lowered glass-transition temperature (Tg), dramatically
    reduced nanoparticle consistency and rendered them too sensitive to solubilization
    when diluted in an aqueous medium. From MALDI-TOF spectroscopy analysis, performed
    on intact colloids, emerged some structural information about these oligomeric
    species which could result from an intramolecular cyclization mechanism occurring
    soon in the course of the polymerization process. Thus, with the objective of
    overcoming these drawbacks, this contribution deals with the variations of manufacturing
    specifications such as pH and magnetic stirring speed to try and modulate molecular
    weight (Mw) of nanoparticle constituents and reduce oligomer concentration. Although
    the analyses performed on these new nanoparticles were rather encouraging, the
    colloid formation yield became so low that it required the developement of other
    methodologies, excluding a previous emulsion step, and allowing a controlled production
    of PMM 2.1.2-made nanoparticles having better physico-chemical characteristics
    while keeping good pharmaceutical capabilities.
article_processing_charge: No
article_type: original
author:
- first_name: P
  full_name: Breton, P
  last_name: Breton
- first_name: X
  full_name: Guillon, X
  last_name: Guillon
- first_name: D
  full_name: Roy, D
  last_name: Roy
- first_name: F
  full_name: Lescure, F
  last_name: Lescure
- first_name: G
  full_name: Riess, G
  last_name: Riess
- first_name: N
  full_name: Bru, N
  last_name: Bru
- first_name: Charles
  full_name: Roques-Carmes, Charles
  id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82
  last_name: Roques-Carmes
citation:
  ama: Breton P, Guillon X, Roy D, et al. Physico-chemical characterization, preparation
    and performance of poly (methylidene malonate 2.1.2) nanoparticles. <i>Biomaterials</i>.
    1998;19(1-3):271-281. doi:<a href="https://doi.org/10.1016/s0142-9612(97)00243-3">10.1016/s0142-9612(97)00243-3</a>
  apa: Breton, P., Guillon, X., Roy, D., Lescure, F., Riess, G., Bru, N., &#38; Roques-Carmes,
    C. (1998). Physico-chemical characterization, preparation and performance of poly
    (methylidene malonate 2.1.2) nanoparticles. <i>Biomaterials</i>. Elsevier. <a
    href="https://doi.org/10.1016/s0142-9612(97)00243-3">https://doi.org/10.1016/s0142-9612(97)00243-3</a>
  chicago: Breton, P, X Guillon, D Roy, F Lescure, G Riess, N Bru, and Charles Roques-Carmes.
    “Physico-Chemical Characterization, Preparation and Performance of Poly (Methylidene
    Malonate 2.1.2) Nanoparticles.” <i>Biomaterials</i>. Elsevier, 1998. <a href="https://doi.org/10.1016/s0142-9612(97)00243-3">https://doi.org/10.1016/s0142-9612(97)00243-3</a>.
  ieee: P. Breton <i>et al.</i>, “Physico-chemical characterization, preparation and
    performance of poly (methylidene malonate 2.1.2) nanoparticles,” <i>Biomaterials</i>,
    vol. 19, no. 1–3. Elsevier, pp. 271–281, 1998.
  ista: Breton P, Guillon X, Roy D, Lescure F, Riess G, Bru N, Roques-Carmes C. 1998.
    Physico-chemical characterization, preparation and performance of poly (methylidene
    malonate 2.1.2) nanoparticles. Biomaterials. 19(1–3), 271–281.
  mla: Breton, P., et al. “Physico-Chemical Characterization, Preparation and Performance
    of Poly (Methylidene Malonate 2.1.2) Nanoparticles.” <i>Biomaterials</i>, vol.
    19, no. 1–3, Elsevier, 1998, pp. 271–81, doi:<a href="https://doi.org/10.1016/s0142-9612(97)00243-3">10.1016/s0142-9612(97)00243-3</a>.
  short: P. Breton, X. Guillon, D. Roy, F. Lescure, G. Riess, N. Bru, C. Roques-Carmes,
    Biomaterials 19 (1998) 271–281.
date_created: 2026-03-30T12:22:47Z
date_published: 1998-01-01T00:00:00Z
date_updated: 2026-04-15T12:48:31Z
day: '01'
ddc:
- '530'
doi: 10.1016/s0142-9612(97)00243-3
extern: '1'
external_id:
  pmid:
  - ' 9678876'
fulldoi: https://doi.org/10.1016/s0142-9612(97)00243-3
intvolume: '        19'
issue: 1-3
keyword:
- Colloid physico-chemical analysis
- Colloidal drug carriers
- MALDI-TOF spectroscopy
- Nanoparticles
- Poly(methylidene malonate)
- Scanning electron microscopy
language:
- iso: eng
month: '01'
oa_version: None
page: 271-281
pmid: 1
publication: Biomaterials
publication_identifier:
  issn:
  - 0142-9612
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Physico-chemical characterization, preparation and performance of poly (methylidene
  malonate 2.1.2) nanoparticles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '1998'
...