article published yes Joshua Chen author Sachin Vaidya author Simo Pajovic author Seou Choi author William Michaels author Louis Martin-Monier author Juejun Hu author Carol Cogswell author Charles Roques-Carmes author e2e68fc9-6505-11ef-a541-eb4e72cc3e82 Marin Soljačić author Recent research in nanophotonics for scintillation-based imaging has demonstrated promising improvements in scintillator performance. In parallel, advances in nanophotonics have enabled wavefront control through metasurfaces, a capability that has transformed fields such as microscopy by allowing tailored control of optical propagation. This naturally raises the following question, which we address in this Perspective: can wavefront-control strategies be leveraged to improve scintillation-based imaging? To answer this question, we explore nanophotonic- and metasurface-enabled wavefront control in scintillators to mitigate image blurring arising from their intrinsically diffuse light emission. While depth-of-field extension in scintillation faces fundamental limitations absent in microscopy, this approach reveals promising avenues, including stacked scintillators, selective spatial-frequency enhancement, and X-ray energy-dependent imaging. These results clarify the key distinctions in adapting wavefront engineering to scintillation and its potential to enable tailored detection strategies. American Chemical Society2026 eng 2330-4022 2601.0983010.1021/acsphotonics.5c03124 1371757–1766 yes Chen J, Vaidya S, Pajovic S, Choi S, Michaels W, Martin-Monier L, Hu J, Cogswell C, Roques-Carmes C, Soljačić M. 2026. Wavefront engineering for scintillation-based imaging. ACS Photonics. 13(7), 1757–1766. Chen, J., Vaidya, S., Pajovic, S., Choi, S., Michaels, W., Martin-Monier, L., … Soljačić, M. (2026). Wavefront engineering for scintillation-based imaging. <i>ACS Photonics</i>. American Chemical Society. <a href="https://doi.org/10.1021/acsphotonics.5c03124">https://doi.org/10.1021/acsphotonics.5c03124</a> J. Chen, S. Vaidya, S. Pajovic, S. Choi, W. Michaels, L. Martin-Monier, J. Hu, C. Cogswell, C. Roques-Carmes, M. Soljačić, ACS Photonics 13 (2026) 1757–1766. Chen, Joshua, et al. “Wavefront Engineering for Scintillation-Based Imaging.” <i>ACS Photonics</i>, vol. 13, no. 7, American Chemical Society, 2026, pp. 1757–1766, doi:<a href="https://doi.org/10.1021/acsphotonics.5c03124">10.1021/acsphotonics.5c03124</a>. Chen, Joshua, Sachin Vaidya, Simo Pajovic, Seou Choi, William Michaels, Louis Martin-Monier, Juejun Hu, Carol Cogswell, Charles Roques-Carmes, and Marin Soljačić. “Wavefront Engineering for Scintillation-Based Imaging.” <i>ACS Photonics</i>. American Chemical Society, 2026. <a href="https://doi.org/10.1021/acsphotonics.5c03124">https://doi.org/10.1021/acsphotonics.5c03124</a>. J. Chen <i>et al.</i>, “Wavefront engineering for scintillation-based imaging,” <i>ACS Photonics</i>, vol. 13, no. 7. American Chemical Society, pp. 1757–1766, 2026. Chen J, Vaidya S, Pajovic S, et al. Wavefront engineering for scintillation-based imaging. <i>ACS Photonics</i>. 2026;13(7):1757–1766. doi:<a href="https://doi.org/10.1021/acsphotonics.5c03124">10.1021/acsphotonics.5c03124</a> 215322026-03-30T12:22:47Z2026-05-05T07:53:27Z