---
res:
  bibo_abstract:
  - Structural and functional differences between brain hemispheres are a common feature
    of animal nervous systems with reduced bilateral asymmetry often linked to impaired
    cognitive performance. How neuronal left-right asymmetry is initiated and integrated
    into a bilaterally symmetrical ground pattern is poorly understood. Here, we show
    that the directional asymmetry of a Drosophila central brain circuit originates
    from axonal interactions of two types of bilateral pioneer neurons. Subsequent
    recruitment of neighboring neurons into the asymmetric neuropil primordium results
    in hemisphere-specific microcircuits. Circuit lateralization requires dynamic
    expression of the cell adhesion molecule Fasciclin 2 to maintain structural plasticity
    in axonal remodeling. Reduced circuit asymmetry following cell type–specific Fasciclin
    2 manipulation affects adult brain function. These results reveal an unexpected
    degree of developmental plasticity of late-born Drosophila neurons in the formation
    of a circuit node via the lateralized recruitment of symmetric circuit components.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Johann W.
      foaf_name: Markovitsch, Johann W.
      foaf_surname: Markovitsch
  - foaf_Person:
      foaf_givenName: Daniel
      foaf_name: Mitić, Daniel
      foaf_surname: Mitić
  - foaf_Person:
      foaf_givenName: Alisa
      foaf_name: Del Pilar Jiménez García, Alisa
      foaf_surname: Del Pilar Jiménez García
  - foaf_Person:
      foaf_givenName: Alsberga
      foaf_name: Zane, Alsberga
      foaf_surname: Zane
      foaf_workInfoHomepage: http://www.librecat.org/personId=60f7509a-f652-11ea-9d86-b963d6490d7c
    orcid: 0009-0003-0415-7603
  - foaf_Person:
      foaf_givenName: Sarah
      foaf_name: Kainz, Sarah
      foaf_surname: Kainz
  - foaf_Person:
      foaf_givenName: Rashmit
      foaf_name: Kaur, Rashmit
      foaf_surname: Kaur
  - foaf_Person:
      foaf_givenName: Thomas
      foaf_name: Hummel, Thomas
      foaf_surname: Hummel
  bibo_doi: 10.1126/sciadv.aea6020
  bibo_issue: '13'
  bibo_volume: 12
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2375-2548
  dct_language: eng
  dct_publisher: American Association for the Advancement of Science@
  dct_title: Sequential formation of Drosophila circuit asymmetry via prolonged structural
    plasticity@
...