@article{21730,
  abstract     = {Hydrogen peroxide (H2O2) is a crucial member of the reactive oxygen species (ROS) family, playing roles in cellular signalling and immune responses in human health. Moreover, it is a potential biomarker of diabetes when present in aberrant concentrations. Therefore, monitoring trace levels of H2O2 has become a research hotspot for analytical and sensor chemists. In this context, we report a rhodamine-based fluorescent probe (RN), which shows excellent fluorescent enhancement at 555 nm upon the addition of H2O2 along with a low limit of detection (LOD) of 0.67 ppm and fast response (∼2 min). The probe is highly selective for H2O2, showing no fluorescence enhancement with other ROS. RN is synthesised in a one-pot chemical reaction using rhodamine 6G (R6G) and 4,7,10-trioxa-1,13-tridecanediamine (TTDA). H2O2 detection in pre-treated milk samples proves its real-world viability. We found that RN shows low cytotoxicity, which allowed us to successfully explore its potential to monitor H2O2 generation in a diabetic L929 skin cell line and diabetic mice liver tissue. This result demonstrates promising features for assessing early diabetic progression through fluorescence imaging.},
  author       = {Mondal, Moumita and Ghorai, Pravat and Samadder, Asmita and Freunberger, Stefan Alexander and Banerjee, Priyabrata},
  issn         = {2050-7518},
  journal      = {Journal of Materials Chemistry B},
  publisher    = {Royal Society of Chemistry},
  title        = {{H2O2 responsive rhodamine-based probe for monitoring early-stage diabetes diagnosis}},
  doi          = {10.1039/d5tb02687c},
  year         = {2026},
}