[{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"epub_ahead","article_type":"original","author":[{"last_name":"Mondal","first_name":"Moumita","full_name":"Mondal, Moumita"},{"full_name":"Ghorai, Pravat","first_name":"Pravat","last_name":"Ghorai"},{"full_name":"Samadder, Asmita","first_name":"Asmita","last_name":"Samadder"},{"orcid":"0000-0003-2902-5319","last_name":"Freunberger","first_name":"Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","full_name":"Freunberger, Stefan Alexander"},{"last_name":"Banerjee","full_name":"Banerjee, Priyabrata","first_name":"Priyabrata"}],"OA_type":"closed access","acknowledgement":"MM acknowledges the Government of India for DST-INSPIRE\r\nfellowship [IF200389] and Federal Ministry of Education, Science and Research (BMBWF) and the OeAD – Austria’s Agency for Education and Internationalisation for an Ernst Mach Grant, weltweit (grant number MPC-2024-01518) for research internship at ISTA. The Scientific Service Units of ISTA supported this research through resources provided by the Lab Support Facility. PG acknowledges the ANRF, India, for his NPDF fellowship (File no. PDF/2022/001960). PB acknowledges ANRF, India, for the SERB-CRG sponsored project GAP-240712 (vide reference no. CRG/2022/001679).","scopus_import":"1","date_published":"2026-04-10T00:00:00Z","abstract":[{"text":"Hydrogen peroxide (H2O2) is a crucial member of the reactive oxygen species (ROS) family, playing roles in cellular signalling and immune responses in human health. Moreover, it is a potential biomarker of diabetes when present in aberrant concentrations. Therefore, monitoring trace levels of H2O2 has become a research hotspot for analytical and sensor chemists. In this context, we report a rhodamine-based fluorescent probe (RN), which shows excellent fluorescent enhancement at 555 nm upon the addition of H2O2 along with a low limit of detection (LOD) of 0.67 ppm and fast response (∼2 min). The probe is highly selective for H2O2, showing no fluorescence enhancement with other ROS. RN is synthesised in a one-pot chemical reaction using rhodamine 6G (R6G) and 4,7,10-trioxa-1,13-tridecanediamine (TTDA). H2O2 detection in pre-treated milk samples proves its real-world viability. We found that RN shows low cytotoxicity, which allowed us to successfully explore its potential to monitor H2O2 generation in a diabetic L929 skin cell line and diabetic mice liver tissue. This result demonstrates promising features for assessing early diabetic progression through fluorescence imaging.","lang":"eng"}],"status":"public","pmid":1,"month":"04","article_processing_charge":"No","title":"H2O2 responsive rhodamine-based probe for monitoring early-stage diabetes diagnosis","_id":"21730","year":"2026","oa_version":"None","acknowledged_ssus":[{"_id":"LifeSc"}],"date_created":"2026-04-13T07:45:26Z","department":[{"_id":"StFr"}],"date_updated":"2026-04-16T05:44:49Z","corr_author":"1","external_id":{"pmid":["41958432"]},"language":[{"iso":"eng"}],"quality_controlled":"1","publication_identifier":{"issn":["2050-750X"],"eissn":["2050-7518"]},"publication":"Journal of Materials Chemistry B","day":"10","publisher":"Royal Society of Chemistry","doi":"10.1039/d5tb02687c","type":"journal_article","citation":{"apa":"Mondal, M., Ghorai, P., Samadder, A., Freunberger, S. A., &#38; Banerjee, P. (2026). H2O2 responsive rhodamine-based probe for monitoring early-stage diabetes diagnosis. <i>Journal of Materials Chemistry B</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d5tb02687c\">https://doi.org/10.1039/d5tb02687c</a>","ista":"Mondal M, Ghorai P, Samadder A, Freunberger SA, Banerjee P. 2026. H2O2 responsive rhodamine-based probe for monitoring early-stage diabetes diagnosis. Journal of Materials Chemistry B.","mla":"Mondal, Moumita, et al. “H2O2 Responsive Rhodamine-Based Probe for Monitoring Early-Stage Diabetes Diagnosis.” <i>Journal of Materials Chemistry B</i>, Royal Society of Chemistry, 2026, doi:<a href=\"https://doi.org/10.1039/d5tb02687c\">10.1039/d5tb02687c</a>.","ieee":"M. Mondal, P. Ghorai, A. Samadder, S. A. Freunberger, and P. Banerjee, “H2O2 responsive rhodamine-based probe for monitoring early-stage diabetes diagnosis,” <i>Journal of Materials Chemistry B</i>. Royal Society of Chemistry, 2026.","short":"M. Mondal, P. Ghorai, A. Samadder, S.A. Freunberger, P. Banerjee, Journal of Materials Chemistry B (2026).","chicago":"Mondal, Moumita, Pravat Ghorai, Asmita Samadder, Stefan Alexander Freunberger, and Priyabrata Banerjee. “H2O2 Responsive Rhodamine-Based Probe for Monitoring Early-Stage Diabetes Diagnosis.” <i>Journal of Materials Chemistry B</i>. Royal Society of Chemistry, 2026. <a href=\"https://doi.org/10.1039/d5tb02687c\">https://doi.org/10.1039/d5tb02687c</a>.","ama":"Mondal M, Ghorai P, Samadder A, Freunberger SA, Banerjee P. H2O2 responsive rhodamine-based probe for monitoring early-stage diabetes diagnosis. <i>Journal of Materials Chemistry B</i>. 2026. doi:<a href=\"https://doi.org/10.1039/d5tb02687c\">10.1039/d5tb02687c</a>"}}]