---
OA_type: closed access
_id: '21730'
abstract:
- lang: eng
  text: Hydrogen peroxide (H2O2) is a crucial member of the reactive oxygen species
    (ROS) family, playing roles in cellular signalling and immune responses in human
    health. Moreover, it is a potential biomarker of diabetes when present in aberrant
    concentrations. Therefore, monitoring trace levels of H2O2 has become a research
    hotspot for analytical and sensor chemists. In this context, we report a rhodamine-based
    fluorescent probe (RN), which shows excellent fluorescent enhancement at 555 nm
    upon the addition of H2O2 along with a low limit of detection (LOD) of 0.67 ppm
    and fast response (∼2 min). The probe is highly selective for H2O2, showing no
    fluorescence enhancement with other ROS. RN is synthesised in a one-pot chemical
    reaction using rhodamine 6G (R6G) and 4,7,10-trioxa-1,13-tridecanediamine (TTDA).
    H2O2 detection in pre-treated milk samples proves its real-world viability. We
    found that RN shows low cytotoxicity, which allowed us to successfully explore
    its potential to monitor H2O2 generation in a diabetic L929 skin cell line and
    diabetic mice liver tissue. This result demonstrates promising features for assessing
    early diabetic progression through fluorescence imaging.
acknowledged_ssus:
- _id: LifeSc
acknowledgement: "MM acknowledges the Government of India for DST-INSPIRE\r\nfellowship
  [IF200389] and Federal Ministry of Education, Science and Research (BMBWF) and the
  OeAD – Austria’s Agency for Education and Internationalisation for an Ernst Mach
  Grant, weltweit (grant number MPC-2024-01518) for research internship at ISTA. The
  Scientific Service Units of ISTA supported this research through resources provided
  by the Lab Support Facility. PG acknowledges the ANRF, India, for his NPDF fellowship
  (File no. PDF/2022/001960). PB acknowledges ANRF, India, for the SERB-CRG sponsored
  project GAP-240712 (vide reference no. CRG/2022/001679)."
article_processing_charge: No
article_type: original
author:
- first_name: Moumita
  full_name: Mondal, Moumita
  last_name: Mondal
- first_name: Pravat
  full_name: Ghorai, Pravat
  last_name: Ghorai
- first_name: Asmita
  full_name: Samadder, Asmita
  last_name: Samadder
- first_name: Stefan Alexander
  full_name: Freunberger, Stefan Alexander
  id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
  last_name: Freunberger
  orcid: 0000-0003-2902-5319
- first_name: Priyabrata
  full_name: Banerjee, Priyabrata
  last_name: Banerjee
citation:
  ama: Mondal M, Ghorai P, Samadder A, Freunberger SA, Banerjee P. H2O2 responsive
    rhodamine-based probe for monitoring early-stage diabetes diagnosis. <i>Journal
    of Materials Chemistry B</i>. 2026. doi:<a href="https://doi.org/10.1039/d5tb02687c">10.1039/d5tb02687c</a>
  apa: Mondal, M., Ghorai, P., Samadder, A., Freunberger, S. A., &#38; Banerjee, P.
    (2026). H2O2 responsive rhodamine-based probe for monitoring early-stage diabetes
    diagnosis. <i>Journal of Materials Chemistry B</i>. Royal Society of Chemistry.
    <a href="https://doi.org/10.1039/d5tb02687c">https://doi.org/10.1039/d5tb02687c</a>
  chicago: Mondal, Moumita, Pravat Ghorai, Asmita Samadder, Stefan Alexander Freunberger,
    and Priyabrata Banerjee. “H2O2 Responsive Rhodamine-Based Probe for Monitoring
    Early-Stage Diabetes Diagnosis.” <i>Journal of Materials Chemistry B</i>. Royal
    Society of Chemistry, 2026. <a href="https://doi.org/10.1039/d5tb02687c">https://doi.org/10.1039/d5tb02687c</a>.
  ieee: M. Mondal, P. Ghorai, A. Samadder, S. A. Freunberger, and P. Banerjee, “H2O2
    responsive rhodamine-based probe for monitoring early-stage diabetes diagnosis,”
    <i>Journal of Materials Chemistry B</i>. Royal Society of Chemistry, 2026.
  ista: Mondal M, Ghorai P, Samadder A, Freunberger SA, Banerjee P. 2026. H2O2 responsive
    rhodamine-based probe for monitoring early-stage diabetes diagnosis. Journal of
    Materials Chemistry B.
  mla: Mondal, Moumita, et al. “H2O2 Responsive Rhodamine-Based Probe for Monitoring
    Early-Stage Diabetes Diagnosis.” <i>Journal of Materials Chemistry B</i>, Royal
    Society of Chemistry, 2026, doi:<a href="https://doi.org/10.1039/d5tb02687c">10.1039/d5tb02687c</a>.
  short: M. Mondal, P. Ghorai, A. Samadder, S.A. Freunberger, P. Banerjee, Journal
    of Materials Chemistry B (2026).
corr_author: '1'
date_created: 2026-04-13T07:45:26Z
date_published: 2026-04-10T00:00:00Z
date_updated: 2026-04-16T05:44:49Z
day: '10'
department:
- _id: StFr
doi: 10.1039/d5tb02687c
external_id:
  pmid:
  - '41958432'
language:
- iso: eng
month: '04'
oa_version: None
pmid: 1
publication: Journal of Materials Chemistry B
publication_identifier:
  eissn:
  - 2050-7518
  issn:
  - 2050-750X
publication_status: epub_ahead
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: H2O2 responsive rhodamine-based probe for monitoring early-stage diabetes diagnosis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...