---
res:
  bibo_abstract:
  - As vertebrates transitioned from water to land, locomotion shifted from undulatory
    swimming to limb-based movement. How spinal circuits and their cell types evolved
    to support this transition remains unclear. We leverage frog metamorphosis, which
    recapitulates this transition within a single organism, to define how spinal circuits
    generate aquatic versus terrestrial motor patterns. At swim stages, spinal architecture
    is uniform, with a transcriptionally and anatomically homogeneous motor and interneurons.
    As limbs develop and their movement complexifies, spinal circuits expand in neuron
    number and subtype diversity. This expansion is most pronounced for V1 inhibitory
    neurons, which increase ∼70-fold and diversify into transcriptionally distinct
    subtypes. Disrupting transcription factors defining emerging motor and V1 populations
    reveals molecular segregation between swim and limb circuits, highlighting the
    role of subtype diversity in motor coordination. A multifold increase in inhibitory
    neuron diversity thus underlies the tail-to-limb locomotor transition, providing
    a framework for spinal circuit adaptation during vertebrate evolution.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: David
      foaf_name: Vijatovic, David
      foaf_surname: Vijatovic
      foaf_workInfoHomepage: http://www.librecat.org/personId=cf391e77-ec3c-11ea-a124-d69323410b58
  - foaf_Person:
      foaf_givenName: 'Florina Alexandra '
      foaf_name: 'Toma, Florina Alexandra '
      foaf_surname: Toma
      foaf_workInfoHomepage: http://www.librecat.org/personId=2f73f876-f128-11eb-9611-b96b5a30cb0e
  - foaf_Person:
      foaf_givenName: Y
      foaf_name: Ignatyev, Y
      foaf_surname: Ignatyev
  - foaf_Person:
      foaf_givenName: Zoe P
      foaf_name: Harrington, Zoe P
      foaf_surname: Harrington
      foaf_workInfoHomepage: http://www.librecat.org/personId=a8144562-32c9-11ee-b5ce-d9800628bda2
    orcid: 0009-0008-0158-4032
  - foaf_Person:
      foaf_givenName: Christoph M
      foaf_name: Sommer, Christoph M
      foaf_surname: Sommer
      foaf_workInfoHomepage: http://www.librecat.org/personId=4DF26D8C-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-1216-9105
  - foaf_Person:
      foaf_givenName: Robert
      foaf_name: Hauschild, Robert
      foaf_surname: Hauschild
      foaf_workInfoHomepage: http://www.librecat.org/personId=4E01D6B4-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-9843-3522
  - foaf_Person:
      foaf_givenName: Matthijs Geert
      foaf_name: Smits, Matthijs Geert
      foaf_surname: Smits
      foaf_workInfoHomepage: http://www.librecat.org/personId=7a231d52-e216-11ee-a0bb-8acd55f8f1f0
  - foaf_Person:
      foaf_givenName: Marco
      foaf_name: Dalla Vecchia, Marco
      foaf_surname: Dalla Vecchia
      foaf_workInfoHomepage: http://www.librecat.org/personId=02a7a869-ff06-11ed-a87f-86649d6077e5
  - foaf_Person:
      foaf_givenName: Alexandra J.
      foaf_name: Trevisan, Alexandra J.
      foaf_surname: Trevisan
  - foaf_Person:
      foaf_givenName: Phillip
      foaf_name: Chapman, Phillip
      foaf_surname: Chapman
  - foaf_Person:
      foaf_givenName: Mara
      foaf_name: Julseth, Mara
      foaf_surname: Julseth
      foaf_workInfoHomepage: http://www.librecat.org/personId=1cf464b2-dc7d-11ea-9b2f-f9b1aa9417d1
  - foaf_Person:
      foaf_givenName: Susan
      foaf_name: Brenner-Morton, Susan
      foaf_surname: Brenner-Morton
  - foaf_Person:
      foaf_givenName: Mariano I.
      foaf_name: Gabitto, Mariano I.
      foaf_surname: Gabitto
  - foaf_Person:
      foaf_givenName: Jeremy S.
      foaf_name: Dasen, Jeremy S.
      foaf_surname: Dasen
  - foaf_Person:
      foaf_givenName: Jay B.
      foaf_name: Bikoff, Jay B.
      foaf_surname: Bikoff
  - foaf_Person:
      foaf_givenName: Lora Beatrice Jaeger
      foaf_name: Sweeney, Lora Beatrice Jaeger
      foaf_surname: Sweeney
      foaf_workInfoHomepage: http://www.librecat.org/personId=56BE8254-C4F0-11E9-8E45-0B23E6697425
    orcid: 0000-0001-9242-5601
  bibo_doi: 10.1016/j.celrep.2026.117227
  bibo_issue: '4'
  bibo_volume: 45
  dct_date: 2026^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2639-1856
  - http://id.crossref.org/issn/2211-1247
  dct_language: eng
  dct_publisher: Elsevier@
  dct_title: Multifold increase in spinal inhibitory cell types with emergence of
    limb movement@
  fabio_hasPubmedId: '41964955 '
...