[{"language":[{"iso":"eng"}],"citation":{"ieee":"C. C. Cole <i>et al.</i>, “Supramolecular assembly of collagen-mimetic eptide D-periodic fibrils and nanoassemblies,” <i>Biomacromolecules</i>, vol. 27, no. 4. American Chemical Society, pp. 2956–2965, 2026.","chicago":"Cole, Carson C., Mark A.B. Kreutzberger, Kevin Klein, Kiana A. Cahue, Brett H. Pogostin, Adam C. Farsheed, Joseph W.R. Swain, et al. “Supramolecular Assembly of Collagen-Mimetic Eptide D-Periodic Fibrils and Nanoassemblies.” <i>Biomacromolecules</i>. American Chemical Society, 2026. <a href=\"https://doi.org/10.1021/acs.biomac.6c00345\">https://doi.org/10.1021/acs.biomac.6c00345</a>.","ista":"Cole CC, Kreutzberger MAB, Klein K, Cahue KA, Pogostin BH, Farsheed AC, Swain JWR, Bui TH, Dey A, Makhoul JT, Dubackic M, Pal A, Olsson U, Šarić A, Egelman EH, Hartgerink JD. 2026. Supramolecular assembly of collagen-mimetic eptide D-periodic fibrils and nanoassemblies. Biomacromolecules. 27(4), 2956–2965.","mla":"Cole, Carson C., et al. “Supramolecular Assembly of Collagen-Mimetic Eptide D-Periodic Fibrils and Nanoassemblies.” <i>Biomacromolecules</i>, vol. 27, no. 4, American Chemical Society, 2026, pp. 2956–65, doi:<a href=\"https://doi.org/10.1021/acs.biomac.6c00345\">10.1021/acs.biomac.6c00345</a>.","ama":"Cole CC, Kreutzberger MAB, Klein K, et al. Supramolecular assembly of collagen-mimetic eptide D-periodic fibrils and nanoassemblies. <i>Biomacromolecules</i>. 2026;27(4):2956-2965. doi:<a href=\"https://doi.org/10.1021/acs.biomac.6c00345\">10.1021/acs.biomac.6c00345</a>","apa":"Cole, C. C., Kreutzberger, M. A. B., Klein, K., Cahue, K. A., Pogostin, B. H., Farsheed, A. C., … Hartgerink, J. D. (2026). Supramolecular assembly of collagen-mimetic eptide D-periodic fibrils and nanoassemblies. <i>Biomacromolecules</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.biomac.6c00345\">https://doi.org/10.1021/acs.biomac.6c00345</a>","short":"C.C. Cole, M.A.B. Kreutzberger, K. Klein, K.A. Cahue, B.H. Pogostin, A.C. Farsheed, J.W.R. Swain, T.H. Bui, A. Dey, J.T. Makhoul, M. Dubackic, A. Pal, U. Olsson, A. Šarić, E.H. Egelman, J.D. Hartgerink, Biomacromolecules 27 (2026) 2956–2965."},"day":"13","date_updated":"2026-05-06T05:43:44Z","date_published":"2026-04-13T00:00:00Z","month":"04","main_file_link":[{"url":"https://doi.org/10.1101/2025.02.15.637692","open_access":"1"}],"article_type":"original","doi":"10.1021/acs.biomac.6c00345","year":"2026","abstract":[{"lang":"eng","text":"The collagen triple helix assembles hierarchically into bundled oligomers, solvated networks, and fibers. Synthetic peptide assemblies, driven by supramolecular interactions, can form single triple helices through intrahelical amino acid pairs; however, the principles guiding interhelical associations into higher-order structures remain unclear. Here, we incorporate cation−π and electrostatic charge pairs to probe interhelical interactions and elucidate the mechanisms driving triple helix assembly into fibrils, nanotubes, and nanosheets. Introducing cation−π pairs into a fibrillating collagen mimetic resulted in D-periodic fibrils with pH-sensitive gelation. By alternating the presentation of electrostatic and cation−π pairs, the assembly of another D-periodic fibril featuring inner and outer triple-helical layers was resolved by cryo electron microscopy to a resolution of 8 Å. At physiological pH, antiparallel association of these triple helices leads to the formation of nanotubes. The packing behavior of triple helices correlates with the interhelical interactions, where parallel associations favor fibril formation and antiparallel interactions drive nanotube and nanosheet assembly. These self-assembling triple-helical peptides demonstrate how packing of higher-order structures can be tailored with supramolecular interactions and establish the relationship of different hierarchical collagen-mimetic assemblies as pH-dependent."}],"publication_status":"published","OA_type":"green","article_processing_charge":"No","publisher":"American Chemical Society","issue":"4","title":"Supramolecular assembly of collagen-mimetic eptide D-periodic fibrils and nanoassemblies","date_created":"2026-04-19T22:07:46Z","oa":1,"author":[{"full_name":"Cole, Carson C.","last_name":"Cole","first_name":"Carson C."},{"full_name":"Kreutzberger, Mark A.B.","last_name":"Kreutzberger","first_name":"Mark A.B."},{"last_name":"Klein","full_name":"Klein, Kevin","first_name":"Kevin","id":"1e7ede04-9e54-11f0-9ec4-8d4d5563c398"},{"first_name":"Kiana A.","full_name":"Cahue, Kiana A.","last_name":"Cahue"},{"first_name":"Brett H.","full_name":"Pogostin, Brett H.","last_name":"Pogostin"},{"first_name":"Adam C.","full_name":"Farsheed, Adam C.","last_name":"Farsheed"},{"first_name":"Joseph W.R.","last_name":"Swain","full_name":"Swain, Joseph W.R."},{"last_name":"Bui","full_name":"Bui, Thi H.","first_name":"Thi H."},{"first_name":"Arghadip","last_name":"Dey","full_name":"Dey, Arghadip"},{"full_name":"Makhoul, Jonathan T.","last_name":"Makhoul","first_name":"Jonathan T."},{"first_name":"Marija","full_name":"Dubackic, Marija","last_name":"Dubackic"},{"last_name":"Pal","full_name":"Pal, Antara","first_name":"Antara"},{"first_name":"Ulf","full_name":"Olsson, Ulf","last_name":"Olsson"},{"orcid":"0000-0002-7854-2139","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","first_name":"Anđela","last_name":"Šarić","full_name":"Šarić, Anđela"},{"first_name":"Edward H.","full_name":"Egelman, Edward H.","last_name":"Egelman"},{"first_name":"Jeffrey D.","full_name":"Hartgerink, Jeffrey D.","last_name":"Hartgerink"}],"quality_controlled":"1","acknowledgement":"The authors acknowledge Crispin Hetherington and L. Tracy Yu for their technical assistance and insights. This work was funded in part by the National Science Foundation (CHE 2203937), the National Science Foundation Graduate Research Fellowship (Grant No. 1842494), the Welch Foundation (C-2141), the Swedish Research Council (2020-04633), and the NIH (GM122510). This work benefited from using the SasView application, originally developed under NSF award DMR-0520547. SasView contains code developed with funding from the European Union’s Horizon 2020 research and innovation program under the SINE2020 project, Grant Agreement No. 654000. This work was partly done using the Shared Equipment Authority resources at Rice University.","OA_place":"repository","status":"public","oa_version":"Preprint","scopus_import":"1","department":[{"_id":"AnSa"}],"intvolume":"        27","type":"journal_article","publication_identifier":{"eissn":["1526-4602"]},"page":"2956-2965","volume":27,"publication":"Biomacromolecules","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"21749"}]